PMID- 32957136
OWN - NLM
STAT- MEDLINE
DCOM- 20201109
LR  - 20211001
IS  - 1833-3516 (Print)
IS  - 2209-1491 (Electronic)
IS  - 1833-3516 (Linking)
VI  - 50
IP  - 3
DP  - 2020 Sep 30
TI  - Hyperbaric oxygen therapy in a patient with Guillain-Barre syndrome receiving 
      mechanical ventilation.
PG  - 303-305
LID - 10.28920/dhm50.3.303-305 [doi]
AB  - The mortality rate of patients with Guillain-Barre syndrome (GBS) who develop 
      respiratory muscle paralysis and need mechanical ventilation is increased. Though 
      an unestablished indication, hyperbaric oxygen treatment (HBOT) has been used to 
      treat patients with mild GBS who do not have respiratory muscle paralysis. The 
      use of HBOT in severe cases has not been reported. We present a patient with 
      severe GBS who received HBOT while ventilated in a multiplace hyperbaric chamber. 
      Three courses of HBOT (one session per day, 10 sessions per course) were 
      administered with a 2-day rest period between each course. The HBOT protocol was 
      40 minutes at 220 kPa with 25 minutes of compression and decompression. Following 
      weeks of gradual deterioration, motor function improved after the first HBOT 
      session. After eight HBOT sessions, the patient was successfully discontinued 
      from mechanical ventilation and after 10 sessions the patient's muscle strength 
      was significantly improved. After 30 HBOT sessions, the patient had normal 
      breathing and speech, and did not cough when eating. Upper limb muscle strength 
      was graded as 4 on the Medical Research Council (MRC) scale, lower limb muscle 
      strength was graded as MRC 3. The patient was successfully discharged. 
      Mechanically ventilated GBS patients may benefit from HBOT but studies are 
      required to separate spontaneous recovery rates from treatment benefit.
CI  - Copyright: This article is the copyright of the authors who grant Diving and 
      Hyperbaric Medicine a non-exclusive licence to publish the article in electronic 
      and other forms.
FAU - Song, Lisha
AU  - Song L
AD  - Department of Emergency, The First Hospital of Jilin University, Changchun, 
      Jilin, 130021, China.
FAU - Xing, Baopeng
AU  - Xing B
AD  - Department of Emergency, The First Hospital of Jilin University, Changchun, 
      Jilin, 130021, China.
FAU - Yang, Weimin
AU  - Yang W
AD  - Department of Emergency, The First Hospital of Jilin University, Changchun, 
      Jilin, 130021, China.
FAU - Li, Haifeng
AU  - Li H
AD  - Department of Emergency, The First Hospital of Jilin University, Changchun, 
      Jilin, 130021, China.
AD  - Corresponding author: Dr Haifeng Li, Department of Emergency, The First Hospital 
      of Jilin University, Changchun, Jilin, 130021, China, llll558@hotmail.com.
LA  - eng
PT  - Case Reports
PL  - Australia
TA  - Diving Hyperb Med
JT  - Diving and hyperbaric medicine
JID - 101282742
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Clinical Protocols
MH  - *Guillain-Barre Syndrome/complications/therapy
MH  - Humans
MH  - *Hyperbaric Oxygenation
MH  - Oxygen
MH  - Respiration, Artificial
PMC - PMC7819725
OTO - NOTNLM
OT  - Case reports
OT  - Intensive care medicine
OT  - Neurology
OT  - Spinal cord injury
COIS- Conflicts of interest and funding: nil
EDAT- 2020/09/22 06:00
MHDA- 2020/11/11 06:00
PMCR- 2021/09/30
CRDT- 2020/09/21 20:22
PHST- 2020/10/13 00:00 [received]
PHST- 2020/02/05 00:00 [accepted]
PHST- 2020/09/21 20:22 [entrez]
PHST- 2020/09/22 06:00 [pubmed]
PHST- 2020/11/11 06:00 [medline]
PHST- 2021/09/30 00:00 [pmc-release]
AID - 10.28920/dhm50.3.303-305 [doi]
PST - ppublish
SO  - Diving Hyperb Med. 2020 Sep 30;50(3):303-305. doi: 10.28920/dhm50.3.303-305.