PMID- 32958851
OWN - NLM
STAT- MEDLINE
DCOM- 20201217
LR  - 20210921
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 10
IP  - 1
DP  - 2020 Sep 21
TI  - Changes in endothelial function during educational hospitalization and the 
      contributor to improvement of endothelial function in type 2 diabetes mellitus.
PG  - 15384
LID - 10.1038/s41598-020-72341-8 [doi]
LID - 15384
AB  - Only a few reports have examined vascular endothelial function before and after 
      educational hospitalization and the factors that affect it in patients with type 
      2 diabetes mellitus (T2DM). The aim of this study was to assess vascular 
      endothelial function before and after educational hospitalization and identify 
      factors that affect it. In 65 patients with T2DM who underwent peripheral 
      arterial tonometry (EndoPAT) before and after hospitalization, vascular 
      endothelial function (reactive hyperemia index [RHI]), glucose metabolism, lipid 
      metabolism, and blood pressure were assessed before and after hospitalization. 
      The primary endpoint was hospitalization-induced changes in vascular endothelial 
      function. Educational hospitalization significantly improved the natural 
      logarithmically scaled RHI (L_RHI) from 0.555 +/- 0.212 to 0.625 +/- 0.245 
      (p = 0.012). Multivariable logistic regression analysis identified hypoglycemia 
      during hospitalization as the single factor that significantly altered vascular 
      endothelial function (p = 0.019). The odds of achieving normal vascular 
      endothelial function were 0.08 times lower (95% confidence interval, 0.01-0.67) 
      for each episode of hypoglycemia. Furthermore, multivariable analysis identified 
      hypoglycemia during hospitalization as the single factor that worsened L_RHI. Our 
      study showed that educational hospitalization of patients with T2DM improved 
      vascular endothelial function, and that the development of hypoglycemic episodes 
      had a significant negative impact on normalization of vascular endothelial 
      function.
FAU - Goshima, Yukiko
AU  - Goshima Y
AD  - First Department of Internal Medicine, School of Medicine, University of 
      Occupational and Environmental Health Japan, Kitakyushu, Japan.
AD  - Department of Endocrinology and Metabolism, Toranomon Hospital, Tokyo, Japan.
FAU - Okada, Yosuke
AU  - Okada Y
AD  - First Department of Internal Medicine, School of Medicine, University of 
      Occupational and Environmental Health Japan, Kitakyushu, Japan.
FAU - Torimoto, Keiichi
AU  - Torimoto K
AD  - First Department of Internal Medicine, School of Medicine, University of 
      Occupational and Environmental Health Japan, Kitakyushu, Japan.
FAU - Fujino, Yoshihisa
AU  - Fujino Y
AD  - Department of Environmental Epidemiology, Institute of Industrial Ecological 
      Sciences, University of Occupational and Environmental Health Japan, Kitakyushu, 
      Japan.
FAU - Tanaka, Yoshiya
AU  - Tanaka Y
AUID- ORCID: 0000-0002-0807-7139
AD  - First Department of Internal Medicine, School of Medicine, University of 
      Occupational and Environmental Health Japan, Kitakyushu, Japan. 
      tanaka@med.uoeh-u.ac.jp.
LA  - eng
PT  - Journal Article
DEP - 20200921
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Arteries/physiopathology
MH  - Blood Pressure/physiology
MH  - Diabetes Mellitus, Type 2/*metabolism
MH  - Endothelial Cells/metabolism/physiology
MH  - Endothelium/metabolism/physiology
MH  - Endothelium, Vascular/*metabolism/physiology
MH  - Female
MH  - Glucose/metabolism
MH  - Hospitalization/trends
MH  - Humans
MH  - Hyperemia/physiopathology
MH  - Hypoglycemia/physiopathology
MH  - Inpatients/*education
MH  - Lipid Metabolism/physiology
MH  - Male
MH  - Manometry/methods
MH  - Middle Aged
MH  - Risk Factors
PMC - PMC7506545
COIS- The authors declare no competing interests.
EDAT- 2020/09/23 06:00
MHDA- 2020/12/18 06:00
PMCR- 2020/09/21
CRDT- 2020/09/22 05:40
PHST- 2019/12/11 00:00 [received]
PHST- 2020/08/24 00:00 [accepted]
PHST- 2020/09/22 05:40 [entrez]
PHST- 2020/09/23 06:00 [pubmed]
PHST- 2020/12/18 06:00 [medline]
PHST- 2020/09/21 00:00 [pmc-release]
AID - 10.1038/s41598-020-72341-8 [pii]
AID - 72341 [pii]
AID - 10.1038/s41598-020-72341-8 [doi]
PST - epublish
SO  - Sci Rep. 2020 Sep 21;10(1):15384. doi: 10.1038/s41598-020-72341-8.