PMID- 32959603
OWN - NLM
STAT- MEDLINE
DCOM- 20210823
LR  - 20210823
IS  - 2210-6014 (Electronic)
IS  - 2210-6006 (Print)
IS  - 2210-6006 (Linking)
VI  - 10
IP  - 4
DP  - 2020 Dec
TI  - Extraintestinal Manifestations of Inflammatory Bowel Disease in Middle Eastern 
      Patients.
PG  - 298-303
LID - 10.2991/jegh.k.200330.001 [doi]
AB  - BACKGROUND AND AIMS: The Inflammatory Bowel Diseases (IBDs), Crohn's Disease (CD) 
      and Ulcerative Colitis (UC), are gastrointestinal autoimmune disorders with many 
      Extraintestinal Manifestations (EIMs). Previously reported incidences of EIMs in 
      IBD patients have ranged from 10% to 50%. The large variation in occurrence of 
      EIMs has been linked to genetic predisposition. Correlations between individual 
      EIMs are unclear. Therefore, we aim to estimate the incidence of EIMs in a Middle 
      Eastern cohort of patients with IBD and examine possible relationships with EIMs. 
      PATIENTS AND METHODS: We conducted a retrospective study involving all patients 
      included in the King Abdulaziz University IBD information system registry between 
      2013 and 2018. Data on demographics, disease characteristics, and EIMs were 
      extracted and analyzed using descriptive statistics: the standard Student's 
      t-test and chi-squared test. Logistic regression analysis was used to examine 
      associations using STATA software version 11.2 (StataCorp, TX, USA). RESULTS: We 
      reviewed the electronic medical files of 284 patients with confirmed IBD, of 
      which 158 (55.6%) were females, the mean age was 27.8 (+/-15) years; 146 (51.4%) 
      patients had CD and 138 (48.6%) UC. The overall incidence risk of EIMs was 138 
      (52.3%) over a mean duration of follow up of 7.3 (+/-3.9) years. The most common 
      EIM was arthritis (33%), followed by aphthous ulcers (16%). Pyoderma gangrenosum 
      occurred in 8% of patients and appeared to be specific for CD patients (p = 
      0.002), whereas Primary Sclerosing Cholangitis (PSC) was more specific for UC (p 
      = 0.001). Certain EIMs appeared to occur together such as arthritis with PSC (p = 
      0.001). Regression analysis identified disease type (in favor of UC; odds ratio = 
      0.50, p = 0.03) and age at the time of diagnosis (odds ratio = 1.04, p = 0.001) 
      as the only significant predictors of EIMs. CONCLUSION: Our results demonstrate 
      that more than half of IBD patients have at least one EIM. Contrary to what has 
      often been reported, we found that EIMs occur more commonly in UC than CD. A 
      multidisciplinary assessment is recommended as part of IBD management to improve 
      overall health outcomes.
CI  - (c) 2020 Atlantis Press International B.V.
FAU - Adam, Heba
AU  - Adam H
AD  - Department of Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, 
      Saudi Arabia.
FAU - Alqassas, Maryam
AU  - Alqassas M
AD  - Department of Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, 
      Saudi Arabia.
FAU - Saadah, Omar I
AU  - Saadah OI
AD  - Department of Pediatrics, Faculty of Medicine, King Abdulaziz University, Jeddah, 
      Saudi Arabia.
AD  - Inflammatory Bowel Disease Research Group, King Abdulaziz University, Jeddah, 
      Saudi Arabia.
FAU - Mosli, Mahmoud
AU  - Mosli M
AD  - Department of Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, 
      Saudi Arabia.
AD  - Inflammatory Bowel Disease Research Group, King Abdulaziz University, Jeddah, 
      Saudi Arabia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20200412
PL  - Switzerland
TA  - J Epidemiol Glob Health
JT  - Journal of epidemiology and global health
JID - 101592084
SB  - IM
MH  - Humans
MH  - Incidence
MH  - *Inflammatory Bowel Diseases/complications/therapy
MH  - Middle East/epidemiology
MH  - Retrospective Studies
PMC - PMC7758850
OTO - NOTNLM
OT  - Inflammatory bowel disease
OT  - extraintestinal
OT  - incidence
OT  - manifestations
OT  - predictors
COIS- The authors declare they have no conflicts of interest.
EDAT- 2020/09/23 06:00
MHDA- 2021/08/24 06:00
PMCR- 2020/12/01
CRDT- 2020/09/22 05:48
PHST- 2019/08/24 00:00 [received]
PHST- 2020/03/01 00:00 [accepted]
PHST- 2020/09/23 06:00 [pubmed]
PHST- 2021/08/24 06:00 [medline]
PHST- 2020/09/22 05:48 [entrez]
PHST- 2020/12/01 00:00 [pmc-release]
AID - jegh.k.200330.001 [pii]
AID - JEGH-10-4-298 [pii]
AID - 10.2991/jegh.k.200330.001 [doi]
PST - ppublish
SO  - J Epidemiol Glob Health. 2020 Dec;10(4):298-303. doi: 10.2991/jegh.k.200330.001. 
      Epub 2020 Apr 12.