PMID- 32960993
OWN - NLM
STAT- MEDLINE
DCOM- 20210809
LR  - 20210809
IS  - 1932-8737 (Electronic)
IS  - 0160-9289 (Print)
IS  - 0160-9289 (Linking)
VI  - 43
IP  - 12
DP  - 2020 Dec
TI  - Remarkable response to cardiac resynchronization therapy via left bundle branch 
      pacing in patients with true left bundle branch block.
PG  - 1460-1468
LID - 10.1002/clc.23462 [doi]
AB  - BACKGROUND: Left bundle branch pacing (LBBP) has been suggested as an alternative 
      means to deliver cardiac resynchronization therapy (CRT). HYPOTHESIS: LBBP may 
      deliver resynchronization therapy along with an advantage over traditional 
      biventricular (BiV) pacing in clinical outcomes. METHODS: Heart failure patients 
      who presented LBBB morphology according to Strauss's criteria and received 
      successful CRT procedure were enrolled in the present study. Propensity score 
      matching was applied to match patients into LBBP-CRT group and BiV-CRT group. 
      Then, the electrographic data, the echocardiographic data and New York heart 
      association (NYHA) class were compared between the groups. RESULTS: Twenty-one 
      patients with successful LBBP procedure and another 21 matched patients with 
      successful BiV-CRT procedure were finally enrolled in the study. The QRS duration 
      (QRSd) was narrowed from 167.7 +/- 14.9 ms to 111.7 +/- 12.3 ms (P < .0001) in the 
      LBBP-CRT group and from 163.6 +/- 13.8 ms to 130.1 +/- 14.0 ms (P < .0001) in the 
      BiV-CRT group. A trend toward better left ventricular ejection fraction (LVEF) 
      was recorded in the LBBP-CRT group (50.9 +/- 10.7% vs 44.4 +/- 13.3%, P = .12) 
      compared to that in the BiV-CRT group at the 6-month follow-up. A trend toward 
      better echocardiographic response was documented in patients receiving LBBP-CRT 
      procedure (90.5% vs 80.9%, P = .43) and more super CRT response was documented in 
      the LBBP-CRT group (80.9% vs 57.1%, P = .09) compared to that in the BiV-CRT 
      group. CONCLUSIONS: LBBP-CRT can dramatically improve the electrical synchrony in 
      heart failure patients with LBBB. Meanwhile, compared with the traditional 
      BiV-CRT, it has a tendency to significantly improve LVEF and enhance the NYHA 
      cardiac function scores.
CI  - (c) 2020 The Authors. Clinical Cardiology published by Wiley Periodicals LLC.
FAU - Guo, Jincun
AU  - Guo J
AUID- ORCID: 0000-0002-7120-2203
AD  - Division of Cardiology, Xiamen Cardiovascular Hospital, Xiamen University, 
      Xiamen, Fujian, China.
FAU - Li, Linlin
AU  - Li L
AD  - Division of Cardiology, Xiamen Cardiovascular Hospital, Xiamen University, 
      Xiamen, Fujian, China.
FAU - Xiao, Guosheng
AU  - Xiao G
AD  - Division of Cardiology, Xiamen Cardiovascular Hospital, Xiamen University, 
      Xiamen, Fujian, China.
FAU - Ye, Tao
AU  - Ye T
AD  - Division of Cardiology, Xiamen Cardiovascular Hospital, Xiamen University, 
      Xiamen, Fujian, China.
FAU - Huang, Xinyi
AU  - Huang X
AD  - Division of Echocardiography, Xiamen Cardiovascular Hospital, Xiamen University, 
      Xiamen, Fujian, China.
FAU - Meng, Fanqi
AU  - Meng F
AD  - Division of Cardiology, Xiamen Cardiovascular Hospital, Xiamen University, 
      Xiamen, Fujian, China.
FAU - Li, Qiang
AU  - Li Q
AD  - Division of Cardiology, Xiamen Cardiovascular Hospital, Xiamen University, 
      Xiamen, Fujian, China.
FAU - Chen, Simei
AU  - Chen S
AD  - Division of Cardiac Function, Xiamen Cardiovascular Hospital, Xiamen University, 
      Xiamen, Fujian, China.
FAU - Cai, Binni
AU  - Cai B
AD  - Division of Cardiology, Xiamen Cardiovascular Hospital, Xiamen University, 
      Xiamen, Fujian, China.
LA  - eng
GR  - 3502Z20199141/The Guiding Program of Xiamen Science and Technology Department/
GR  - 3502Z20191103/the Key Medical Projects of Xiamen Science and Technology Plan/
PT  - Journal Article
PT  - Observational Study
DEP - 20200922
PL  - United States
TA  - Clin Cardiol
JT  - Clinical cardiology
JID - 7903272
SB  - IM
MH  - Aged
MH  - Bundle-Branch Block/diagnosis/physiopathology/*therapy
MH  - Cardiac Resynchronization Therapy/*methods
MH  - Echocardiography
MH  - *Electrocardiography
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Ventricles/diagnostic imaging/physiopathology
MH  - Humans
MH  - Male
MH  - Prospective Studies
MH  - Stroke Volume/*physiology
MH  - Treatment Outcome
MH  - Ventricular Function, Left/*physiology
PMC - PMC7724211
OTO - NOTNLM
OT  - biventricular pacing
OT  - cardiac resynchronization therapy
OT  - heart failure
OT  - left bundle branch block
OT  - left bundle branch pacing
OT  - physiological pacing
COIS- The authors declared that they have no conflict of interest.
EDAT- 2020/09/23 06:00
MHDA- 2021/08/10 06:00
PMCR- 2020/09/22
CRDT- 2020/09/22 17:12
PHST- 2020/07/31 00:00 [received]
PHST- 2020/08/30 00:00 [revised]
PHST- 2020/09/01 00:00 [accepted]
PHST- 2020/09/23 06:00 [pubmed]
PHST- 2021/08/10 06:00 [medline]
PHST- 2020/09/22 17:12 [entrez]
PHST- 2020/09/22 00:00 [pmc-release]
AID - CLC23462 [pii]
AID - 10.1002/clc.23462 [doi]
PST - ppublish
SO  - Clin Cardiol. 2020 Dec;43(12):1460-1468. doi: 10.1002/clc.23462. Epub 2020 Sep 
      22.