PMID- 32961936
OWN - NLM
STAT- MEDLINE
DCOM- 20201215
LR  - 20201215
IS  - 1660-4601 (Electronic)
IS  - 1661-7827 (Print)
IS  - 1660-4601 (Linking)
VI  - 17
IP  - 18
DP  - 2020 Sep 18
TI  - Hyperhomocysteinemia Concurrent with Metabolic Syndrome Is Independently 
      Associated with Chronic Kidney Disease among Community-Dwelling Adults in an 
      Urban Korean Population.
LID - 10.3390/ijerph17186810 [doi]
LID - 6810
AB  - Elevated homocysteine (Hcy) levels and metabolic syndrome (MetS) are associated 
      with chronic kidney disease (CKD). We investigated the combined effects of 
      hyperhomocysteinemia (HHcy) and MetS on CKD among community-dwelling adults in an 
      urban area of South Korea. We also identified the combination of HHcy and 
      individual MetS components associated with the maximal risk of CKD. A 
      retrospective cross-sectional study involving 19,311 health examinees between 2 
      January 2011 and 31 December 2015 was conducted. The participants were divided 
      into four groups-namely, the HHcy-/MetS-, HHcy-/MetS+, HHcy+/MetS-, and 
      HHcy+/MetS+ groups. CKD was defined as a low eGFR <60 mL/min/1.73 m(2) or 
      albuminuria. The HHcy+/MetS+ group had a higher risk of CKD than the HHcy-/MetS+ 
      group (odds ratio (OR): 1.750, p = 0.002 for males; OR: 3.224, p < 0.001 for 
      females). The HHcy+/MetS+ group had a higher CKD risk than the HHcy+/MetS- group; 
      however, the difference was not statistically significant (OR: 1.070, p = 0.712 
      for males; OR: 1.847, and p < 0.074 for females). HHcy concurrent with MetS 
      increased the CKD risk. Among the combinations of HHcy and MetS components, the 
      coexistence of HHcy and central obesity had the greatest effect on CKD. 
      Therefore, the timely detection and treatment of HHcy and MetS are important for 
      preventing CKD.
FAU - Moon, Hana
AU  - Moon H
AUID- ORCID: 0000-0003-4604-3746
AD  - Department of Family Medicine, School of Medicine, Daegu Catholic University, 
      Daegu 42472, Korea.
FAU - Ko, Hae-Jin
AU  - Ko HJ
AUID- ORCID: 0000-0003-4460-1476
AD  - Department of Family Medicine, School of Medicine, Kyungpook National University, 
      Daegu 41944, Korea.
AD  - Department of Family Medicine, Kyungpook National University Hospital, Daegu 
      41944, Korea.
FAU - Kim, A-Sol
AU  - Kim AS
AUID- ORCID: 0000-0003-2497-9500
AD  - Department of Family Medicine, School of Medicine, Kyungpook National University, 
      Daegu 41944, Korea.
AD  - Department of Family Medicine, Kyungpook National University Chilgok Hospital, 
      Daegu 41404, Korea.
LA  - eng
PT  - Journal Article
DEP - 20200918
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
SB  - IM
MH  - Adult
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - *Hyperhomocysteinemia/complications
MH  - Independent Living
MH  - Male
MH  - *Metabolic Syndrome/complications
MH  - Middle Aged
MH  - *Renal Insufficiency, Chronic/complications
MH  - Republic of Korea
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Urban Population
PMC - PMC7558526
OTO - NOTNLM
OT  - chronic kidney disease
OT  - cross-sectional study
OT  - homocysteine
OT  - metabolic syndrome
OT  - proteinuria
COIS- The authors declare no conflict of interest.
EDAT- 2020/09/24 06:00
MHDA- 2020/12/16 06:00
PMCR- 2020/09/01
CRDT- 2020/09/23 01:02
PHST- 2020/08/11 00:00 [received]
PHST- 2020/09/15 00:00 [revised]
PHST- 2020/09/16 00:00 [accepted]
PHST- 2020/09/23 01:02 [entrez]
PHST- 2020/09/24 06:00 [pubmed]
PHST- 2020/12/16 06:00 [medline]
PHST- 2020/09/01 00:00 [pmc-release]
AID - ijerph17186810 [pii]
AID - ijerph-17-06810 [pii]
AID - 10.3390/ijerph17186810 [doi]
PST - epublish
SO  - Int J Environ Res Public Health. 2020 Sep 18;17(18):6810. doi: 
      10.3390/ijerph17186810.