PMID- 32962295
OWN - NLM
STAT- MEDLINE
DCOM- 20201204
LR  - 20201214
IS  - 1660-4601 (Electronic)
IS  - 1661-7827 (Print)
IS  - 1660-4601 (Linking)
VI  - 17
IP  - 18
DP  - 2020 Sep 20
TI  - Increased Mortality Risk in People with Type 2 Diabetes Mellitus in Lithuania.
LID - 10.3390/ijerph17186870 [doi]
LID - 6870
AB  - This retrospective cohort study aimed to analyze overall and cause-specific 
      mortality risk in people with type 2 diabetes mellitus (T2DM) in Lithuania. 
      Information on the diagnosis of T2DM and glucose-lowering medication was obtained 
      from the National Health Insurance Fund database, causes of death-from death 
      certificates. Sex, age, and calendar period-standardized mortality ratios (SMRs) 
      were calculated. In addition, 89,512 patients were followed-up between 2010 and 
      2017, contributing to the observation period of 592,321 person-years. Overall 
      mortality risk was increased for both sexes (overall SMR = 1.35, 95% confidence 
      interval (CI) 1.34-1.37). Greatest mortality risk was in the age group of 40-49 
      years at diabetes diagnosis (SMR = 1.68, 95% CI 1.60-1.76) and among those who 
      had died before the age of 50 (SMR = 22.04, 95% CI 18.82-25.81). Patients treated 
      with insulin only had the highest SMR (2.43, 95% CI 2.32-2.55). Mortality risk 
      increased with increasing diabetes duration and was higher in women in all these 
      groups. The highest cause-specific SMRs were infection-related causes (SMR = 
      1.44), particularly septicemia (SMR = 1.78), diseases of the circulatory system 
      (SMR = 1.42), especially ischemic heart (SMR = 1.46) and cerebrovascular diseases 
      (SMR = 1.38), as well as diseases of the digestive system (SMR = 1.35). Cancer 
      mortality risk was elevated for women (SMR = 1.13), but not for men (SMR = 0.93). 
      In conclusion, people with T2DM had an excess mortality risk, which was higher in 
      women compared to men, younger people, in those who were diagnosed with T2DM at a 
      younger age, had longer diabetes duration, and who required treatment with 
      insulin.
FAU - Linkeviciute-Ulinskiene, Donata
AU  - Linkeviciute-Ulinskiene D
AUID- ORCID: 0000-0003-1168-2003
AD  - Institute of Biomedical Sciences, Department of Pathology, Forensic Medicine and 
      Pharmacology, Faculty of Medicine, Vilnius University, Ciurlionio g. 21, 03101 
      Vilnius, Lithuania.
FAU - Kaceniene, Auguste
AU  - Kaceniene A
AD  - Laboratory of Cancer Epidemiology, National Cancer Institute, P. Baublio g. 3b, 
      08406 Vilnius, Lithuania.
FAU - Dulskas, Audrius
AU  - Dulskas A
AD  - Laboratory of Cancer Epidemiology, National Cancer Institute, P. Baublio g. 3b, 
      08406 Vilnius, Lithuania.
AD  - Department of Abdominal and General Surgery and Oncology, National Cancer 
      Institute, Santariskiu g. 1, 08406 Vilnius, Lithuania.
FAU - Patasius, Ausvydas
AU  - Patasius A
AUID- ORCID: 0000-0003-3874-2723
AD  - Laboratory of Cancer Epidemiology, National Cancer Institute, P. Baublio g. 3b, 
      08406 Vilnius, Lithuania.
AD  - Institute of Health Sciences, Faculty of Medicine, Vilnius University, Ciurlionio 
      g. 21, 03101 Vilnius, Lithuania.
FAU - Zabuliene, Lina
AU  - Zabuliene L
AD  - Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, 
      Santariskiu g. 2, 08406 Vilnius, Lithuania.
FAU - Smailyte, Giedre
AU  - Smailyte G
AUID- ORCID: 0000-0001-8365-543X
AD  - Laboratory of Cancer Epidemiology, National Cancer Institute, P. Baublio g. 3b, 
      08406 Vilnius, Lithuania.
AD  - Institute of Health Sciences, Faculty of Medicine, Vilnius University, Ciurlionio 
      g. 21, 03101 Vilnius, Lithuania.
LA  - eng
PT  - Journal Article
DEP - 20200920
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
SB  - IM
MH  - Adult
MH  - Cause of Death
MH  - Cohort Studies
MH  - *Diabetes Mellitus, Type 2/complications/mortality
MH  - Female
MH  - Humans
MH  - Lithuania/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Mortality
MH  - Retrospective Studies
PMC - PMC7559991
OTO - NOTNLM
OT  - mortality
OT  - population study
OT  - retrospective cohort study.
OT  - standardized mortality ratio
OT  - type 2 diabetes mellitus
COIS- The authors declare no conflict of interest.
EDAT- 2020/09/24 06:00
MHDA- 2020/12/15 06:00
PMCR- 2020/09/01
CRDT- 2020/09/23 01:03
PHST- 2020/07/12 00:00 [received]
PHST- 2020/09/15 00:00 [revised]
PHST- 2020/09/18 00:00 [accepted]
PHST- 2020/09/23 01:03 [entrez]
PHST- 2020/09/24 06:00 [pubmed]
PHST- 2020/12/15 06:00 [medline]
PHST- 2020/09/01 00:00 [pmc-release]
AID - ijerph17186870 [pii]
AID - ijerph-17-06870 [pii]
AID - 10.3390/ijerph17186870 [doi]
PST - epublish
SO  - Int J Environ Res Public Health. 2020 Sep 20;17(18):6870. doi: 
      10.3390/ijerph17186870.