PMID- 32962459
OWN - NLM
STAT- MEDLINE
DCOM- 20221109
LR  - 20221109
IS  - 1552-6941 (Electronic)
IS  - 1534-7346 (Linking)
VI  - 21
IP  - 4
DP  - 2022 Dec
TI  - The Efficacy of the Transdermal Isosorbide Dinitrate Patch in Patients With 
      Chronic Limb-Threatening Ischemia.
PG  - 477-482
LID - 10.1177/1534734620959515 [doi]
AB  - Recently, the number of patients with peripheral artery disease (PAD), including 
      those with chronic limb-threatening ischemia (CLTI), has increased because of the 
      increasing number of diabetic or dialysis patients worldwide. Revascularization 
      is an important therapy for patients with CLTI. However, we sometimes experience 
      refractory cases with insufficient peripheral circulation or microcirculation 
      after revascularization. In this situation, additional therapy can be 
      administered, such as low-density lipoprotein apheresis, high-pressure oxygen 
      therapy, and spinal cord stimulation. However, they are not effective in some 
      cases. Some reports have also indicated that transdermal isosorbide dinitrate 
      patch (ISDN-P) is a useful therapy for PAD. As the efficacy of ISDN-P for 
      patients with CLTI is not well-known, we examined it in this study. We assessed 
      the skin perfusion pressure (SPP) after affixing an ISDN-P on the foot, because 
      SPP measurement has proved useful in the assessment of PAD and is a good 
      indicator of wound healing potential. The SPP (dorsal and plantar aspects) after 
      ISDN-P application on the foot of healthy volunteers increased (n = 8; mean +/- SD, 
      12.6 +/- 7.9 [P = .12], and 21.2 +/- 7.7 mm Hg [P < .05], respectively), as did SPP 
      of patients with CLTI (n = 10; mean +/- SD, 19.8 +/- 2.5 [P < .01], and 14.1 +/- 5.9 mm 
      Hg [P < .05], respectively). All the patients who received an ISDN-P on the foot 
      had no major complication, and no significant change in blood pressure. In 
      conclusion, the ISDN-P is one of the effective and safe therapies for patients 
      with CLTI.
FAU - Matsui, Akihiro
AU  - Matsui A
AUID- ORCID: 0000-0001-9654-0746
AD  - Kasukabe Chuo General Hospital, Kasukabe, Saitama, Japan.
FAU - Murakami, Manabu
AU  - Murakami M
AD  - Kasukabe Chuo General Hospital, Kasukabe, Saitama, Japan.
FAU - Hata, Shinya
AU  - Hata S
AD  - Kasukabe Chuo General Hospital, Kasukabe, Saitama, Japan.
FAU - Terabe, Yuta
AU  - Terabe Y
AUID- ORCID: 0000-0001-7439-1006
AD  - Kasukabe Chuo General Hospital, Kasukabe, Saitama, Japan.
FAU - Nakabayashi, Keisuke
AU  - Nakabayashi K
AD  - Kasukabe Chuo General Hospital, Kasukabe, Saitama, Japan.
FAU - Kaneko, Nobuhito
AU  - Kaneko N
AD  - Kasukabe Chuo General Hospital, Kasukabe, Saitama, Japan.
FAU - Tanaka, Kazuhiko
AU  - Tanaka K
AD  - Kasukabe Chuo General Hospital, Kasukabe, Saitama, Japan.
FAU - Ando, Hiroshi
AU  - Ando H
AD  - Kasukabe Chuo General Hospital, Kasukabe, Saitama, Japan.
LA  - eng
PT  - Journal Article
DEP - 20200923
PL  - United States
TA  - Int J Low Extrem Wounds
JT  - The international journal of lower extremity wounds
JID - 101128359
RN  - IA7306519N (Isosorbide Dinitrate)
SB  - IM
MH  - Humans
MH  - *Isosorbide Dinitrate
MH  - Chronic Limb-Threatening Ischemia
MH  - *Peripheral Arterial Disease/diagnosis/therapy
MH  - Lower Extremity
MH  - Ischemia/diagnosis/etiology/therapy
OTO - NOTNLM
OT  - chronic limb-threatening ischemia
OT  - peripheral artery disease
OT  - skin perfusion pressure
OT  - transdermal isosorbide dinitrate patch
EDAT- 2020/09/24 06:00
MHDA- 2022/11/10 06:00
CRDT- 2020/09/23 05:54
PHST- 2020/09/24 06:00 [pubmed]
PHST- 2022/11/10 06:00 [medline]
PHST- 2020/09/23 05:54 [entrez]
AID - 10.1177/1534734620959515 [doi]
PST - ppublish
SO  - Int J Low Extrem Wounds. 2022 Dec;21(4):477-482. doi: 10.1177/1534734620959515. 
      Epub 2020 Sep 23.