PMID- 32964054
OWN - NLM
STAT- MEDLINE
DCOM- 20210728
LR  - 20210728
IS  - 2314-6753 (Electronic)
IS  - 2314-6745 (Print)
VI  - 2020
DP  - 2020
TI  - Association between Thyroid Function and Nonalcoholic Fatty Liver Disease in 
      Euthyroid Type 2 Diabetes Patients.
PG  - 6538208
LID - 10.1155/2020/6538208 [doi]
LID - 6538208
AB  - Thyroid function and type 2 diabetes mellitus (T2DM) are both associated with 
      increased risks of adverse clinical outcomes in nonalcoholic fatty liver disease 
      (NAFLD). Our study is aimed at evaluating the association between thyroid 
      function and NAFLD in T2DM patients with normal thyroid function (euthyroid) and 
      analyzing the potential effects of metformin on the pathological process. 
      Overall, 369 T2DM patients were enrolled between July 2017 and September 2018 and 
      stratified into NAFLD and non-NAFLD groups. Data on age, gender, body mass index 
      (BMI, kg/m(2)), metformin use, and basal metabolic rate (BMR) were obtained from 
      participants' records. All patients were tested for biochemical markers, indexes 
      of glucose metabolism, lipid metabolism, bone metabolism, and thyroid function at 
      baseline. Multivariate analyses detected increased odds of NAFLD among 
      individuals with T2DM per unit increase in their BMI and free triiodothyronine 
      (FT3) and thyroid stimulating hormone (TSH); the odds ratios (OR) were 1.25, 
      3.02, and 1.58, respectively (all p < 0.05). Positive correlations were detected 
      between alanine aminotransferase (ALT) and FT3 (r = 0.221, p = 0.010), and 
      negative correlations were noted between TSH and BMR (r = -0.618, p < 0.001) and 
      between BMR and FT3 (r = -0.452, p < 0.001) in T2DM subjects with NAFLD. A 
      significant difference in serum FT3 (t = 2.468, p = 0.0167) and TSH (t = 2.658, p 
      = 0.010) levels was found between obese individuals with NAFLD who used and did 
      not use metformin. The pathological mechanism of T2DM complicated by NAFLD in 
      euthyroid patients may be associated with insulin resistance and a thyroid 
      hormone resistance-like manifestation, i.e., relevant hypothyroidism. Metformin 
      can potentially decrease the double-resistance situation, especially in obese 
      individuals.
CI  - Copyright (c) 2020 Bin Huang et al.
FAU - Huang, Bin
AU  - Huang B
AUID- ORCID: 0000-0002-5257-7464
AD  - Department of Endocrinology, The First Affiliated Hospital of USTC, Division of 
      Life Science and Medicine, University of Science and Technology of China, Hefei, 
      Anhui 230001, China.
FAU - Yang, Shengju
AU  - Yang S
AD  - Department of Endocrinology, The First Affiliated Hospital of USTC, Division of 
      Life Science and Medicine, University of Science and Technology of China, Hefei, 
      Anhui 230001, China.
FAU - Ye, Shandong
AU  - Ye S
AUID- ORCID: 0000-0001-5512-9846
AD  - Department of Endocrinology, The First Affiliated Hospital of USTC, Division of 
      Life Science and Medicine, University of Science and Technology of China, Hefei, 
      Anhui 230001, China.
LA  - eng
PT  - Journal Article
DEP - 20200905
PL  - England
TA  - J Diabetes Res
JT  - Journal of diabetes research
JID - 101605237
RN  - 06LU7C9H1V (Triiodothyronine)
RN  - 9002-71-5 (Thyrotropin)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Diabetes Mellitus, Type 2/blood/complications/*physiopathology
MH  - Female
MH  - Humans
MH  - Insulin Resistance/*physiology
MH  - Male
MH  - Middle Aged
MH  - Non-alcoholic Fatty Liver Disease/blood/complications/*physiopathology
MH  - Obesity/blood/complications/*physiopathology
MH  - Thyroid Function Tests
MH  - Thyroid Gland/*physiopathology
MH  - Thyrotropin/blood
MH  - Thyroxine/blood
MH  - Triiodothyronine/blood
PMC - PMC7492895
COIS- The authors declare that they have no competing interests.
EDAT- 2020/09/24 06:00
MHDA- 2021/07/29 06:00
PMCR- 2020/09/05
CRDT- 2020/09/23 06:36
PHST- 2020/05/31 00:00 [received]
PHST- 2020/08/20 00:00 [revised]
PHST- 2020/08/28 00:00 [accepted]
PHST- 2020/09/23 06:36 [entrez]
PHST- 2020/09/24 06:00 [pubmed]
PHST- 2021/07/29 06:00 [medline]
PHST- 2020/09/05 00:00 [pmc-release]
AID - 10.1155/2020/6538208 [doi]
PST - epublish
SO  - J Diabetes Res. 2020 Sep 5;2020:6538208. doi: 10.1155/2020/6538208. eCollection 
      2020.