PMID- 32964253
OWN - NLM
STAT- MEDLINE
DCOM- 20210520
LR  - 20210520
IS  - 1618-2650 (Electronic)
IS  - 1618-2642 (Linking)
VI  - 412
IP  - 28
DP  - 2020 Nov
TI  - Rapid determination of propylthiouracil and methimazole by surface-enhanced Raman 
      scattering based on sodium alginate-protected silver nanoparticles.
PG  - 7827-7836
LID - 10.1007/s00216-020-02912-1 [doi]
AB  - A rapid, ultrasensitive and selective method has been established to determine 
      antithyroid drugs [propylthiouracil (PTU) and methimazole (MTZ)] by 
      surface-enhanced Raman scattering (SERS). Silver nanoparticles (AgNPs) were 
      synthesized by reduction of silver nitrate (AgNO(3)) with sodium alginate (SA) 
      and were used as SERS substrates. Through optimization of the SERS conditions, 
      including the volume of SA-protected AgNPs solution, pH of Britton-Robinson (BR) 
      buffer solution and concentration of NaCl solution, linear responses were 
      obtained for PTU and MTZ in the concentration ranges of 
      3.02 x 10(-9)-1.06 x 10(-5) mol L(-1) and 1.21 x 10(-9)-1.21 x 10(-5) mol L(-1), 
      respectively. By the present method, the limits of detection (LODs) for the 
      determination of PTU and MTZ were as low as 1.58 x 10(-10) mol L(-1) and 
      2.97 x 10(-11) mol L(-1). The method was successfully applied for the 
      determination of PTU and MTZ in real samples. The recovery of PTU and MTZ from 
      actual samples ranged between 97.20 and 104.80%, with relative standard 
      deviations (RSDs) less than 3.63%.
FAU - Hao, Baoqin
AU  - Hao B
AD  - College of Chemistry, Jilin University, Changchun, 130012, Jilin, China.
FAU - Wu, Jiawei
AU  - Wu J
AD  - College of Chemistry, Jilin University, Changchun, 130012, Jilin, China.
FAU - Ding, Yanru
AU  - Ding Y
AD  - College of Chemistry, Jilin University, Changchun, 130012, Jilin, China.
FAU - Zhang, Lixia
AU  - Zhang L
AD  - College of Chemistry, Jilin University, Changchun, 130012, Jilin, China.
FAU - Zhao, Bing
AU  - Zhao B
AD  - State Key Laboratory of Supramolecular Structure and Materials, Jilin University, 
      Changchun, 130012, Jilin, China.
FAU - Tian, Yuan
AU  - Tian Y
AD  - College of Chemistry, Jilin University, Changchun, 130012, Jilin, China. 
      tianyuan@jlu.edu.cn.
LA  - eng
GR  - No. 20170101174JC/Science-Technology Development Project of Jilin Province of 
      China/
GR  - No. 21327803, 21773080, 21711540292/National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20200922
PL  - Germany
TA  - Anal Bioanal Chem
JT  - Analytical and bioanalytical chemistry
JID - 101134327
RN  - 0 (Alginates)
RN  - 0 (Antithyroid Agents)
RN  - 3M4G523W1G (Silver)
RN  - 554Z48XN5E (Methimazole)
RN  - 721M9407IY (Propylthiouracil)
SB  - IM
MH  - Alginates/*chemistry
MH  - Antithyroid Agents/*analysis
MH  - Limit of Detection
MH  - Metal Nanoparticles/*chemistry
MH  - Methimazole/*analysis
MH  - Microscopy, Electron, Transmission
MH  - Propylthiouracil/*analysis
MH  - Reference Standards
MH  - Reproducibility of Results
MH  - Silver/*chemistry
MH  - Spectrum Analysis, Raman/*methods
OTO - NOTNLM
OT  - Methimazole
OT  - Propylthiouracil
OT  - SERS
OT  - Silver nanoparticles
OT  - Sodium alginate
EDAT- 2020/09/24 06:00
MHDA- 2021/05/21 06:00
CRDT- 2020/09/23 06:37
PHST- 2020/05/14 00:00 [received]
PHST- 2020/08/24 00:00 [accepted]
PHST- 2020/08/16 00:00 [revised]
PHST- 2020/09/24 06:00 [pubmed]
PHST- 2021/05/21 06:00 [medline]
PHST- 2020/09/23 06:37 [entrez]
AID - 10.1007/s00216-020-02912-1 [pii]
AID - 10.1007/s00216-020-02912-1 [doi]
PST - ppublish
SO  - Anal Bioanal Chem. 2020 Nov;412(28):7827-7836. doi: 10.1007/s00216-020-02912-1. 
      Epub 2020 Sep 22.