PMID- 32964554
OWN - NLM
STAT- MEDLINE
DCOM- 20210430
LR  - 20210430
IS  - 1530-6860 (Electronic)
IS  - 0892-6638 (Linking)
VI  - 34
IP  - 11
DP  - 2020 Nov
TI  - Pterostilbene reduces colonic inflammation by suppressing dendritic cell 
      activation and promoting regulatory T cell development.
PG  - 14810-14819
LID - 10.1096/fj.202001502R [doi]
AB  - Dendritic cells (DCs) and T cells play important roles in immune regulation, and 
      modulating their function is an approach for developing preventive or therapeutic 
      strategies against immune disorders. Herein, the effect of pterostilbene (PSB) 
      (3',5'-dimethoxy-resveratrol)-a resveratrol-related polyphenol found in 
      blueberries-on immune regulation was evaluated. Using an in vitro co-culture 
      system, PSB was found to exert the strongest inhibitory effect among all tested 
      resveratrol derivatives on DC-mediated T cell proliferation; moreover, PSB 
      treatment decreased the Th1 and Th17 populations and increased the regulatory T 
      cell (Treg) population. Upon co-stimulation with anti-CD3 and anti-CD28 
      antibodies, PSB inhibited CD4(+) T cell proliferation and differentiation into 
      Th1 cells. Additionally, PSB acted on DCs to suppress the 
      lipopolysaccharide-induced transactivation of genes encoding antigen 
      presentation-related molecules and inflammatory cytokines by attenuating the 
      DNA-binding ability of the transcription factor PU.1. Furthermore, PSB promoted 
      DC-mediated Foxp3(+) Treg differentiation, and PU.1 knockdown increased 
      DC-induced Treg activity. Oral administration of PSB alleviated the symptoms of 
      dextran sulfate sodium-induced colitis and decreased tumor necrosis factor-alpha 
      expression in mice. Thus, PSB treatment ameliorates colonic inflammation.
CI  - (c) 2020 The Authors. The FASEB Journal published by Wiley Periodicals LLC on 
      behalf of Federation of American Societies for Experimental Biology.
FAU - Yashiro, Takuya
AU  - Yashiro T
AD  - Department of Biological Science and Technology, Faculty of Industrial Science 
      and Technology, Tokyo University of Science, Tokyo, Japan.
FAU - Yura, Shiori
AU  - Yura S
AD  - Department of Biological Science and Technology, Faculty of Industrial Science 
      and Technology, Tokyo University of Science, Tokyo, Japan.
FAU - Tobita, Akari
AU  - Tobita A
AD  - Department of Biological Science and Technology, Faculty of Industrial Science 
      and Technology, Tokyo University of Science, Tokyo, Japan.
FAU - Toyoda, Yuki
AU  - Toyoda Y
AD  - Department of Biological Science and Technology, Faculty of Industrial Science 
      and Technology, Tokyo University of Science, Tokyo, Japan.
FAU - Kasakura, Kazumi
AU  - Kasakura K
AD  - Department of Biological Science and Technology, Faculty of Industrial Science 
      and Technology, Tokyo University of Science, Tokyo, Japan.
FAU - Nishiyama, Chiharu
AU  - Nishiyama C
AD  - Department of Biological Science and Technology, Faculty of Industrial Science 
      and Technology, Tokyo University of Science, Tokyo, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200922
PL  - United States
TA  - FASEB J
JT  - FASEB journal : official publication of the Federation of American Societies for 
      Experimental Biology
JID - 8804484
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Cytokines)
RN  - 0 (Forkhead Transcription Factors)
RN  - 0 (Foxp3 protein, mouse)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Stilbenes)
RN  - 0 (Trans-Activators)
RN  - 0 (proto-oncogene protein Spi-1)
RN  - 26R60S6A5I (pterostilbene)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/*pharmacology/therapeutic use
MH  - Cell Line
MH  - Cell Proliferation
MH  - Cells, Cultured
MH  - Colitis, Ulcerative/*drug therapy/immunology
MH  - Colon/drug effects/immunology
MH  - Cytokines/genetics/metabolism
MH  - Dendritic Cells/drug effects/*immunology
MH  - Forkhead Transcription Factors/metabolism
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Proto-Oncogene Proteins/metabolism
MH  - Stilbenes/*pharmacology/therapeutic use
MH  - T-Lymphocytes, Regulatory/drug effects/*immunology/physiology
MH  - Th1 Cells/immunology/physiology
MH  - Th17 Cells/immunology/physiology
MH  - Trans-Activators/metabolism
OTO - NOTNLM
OT  - colitis
OT  - immunosuppression
OT  - pterostilbene
OT  - resveratrol
EDAT- 2020/09/24 06:00
MHDA- 2021/05/01 06:00
CRDT- 2020/09/23 06:42
PHST- 2020/06/16 00:00 [received]
PHST- 2020/08/21 00:00 [revised]
PHST- 2020/08/24 00:00 [accepted]
PHST- 2020/09/24 06:00 [pubmed]
PHST- 2021/05/01 06:00 [medline]
PHST- 2020/09/23 06:42 [entrez]
AID - 10.1096/fj.202001502R [doi]
PST - ppublish
SO  - FASEB J. 2020 Nov;34(11):14810-14819. doi: 10.1096/fj.202001502R. Epub 2020 Sep 
      22.