PMID- 32964735 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220502 IS - 2192-5682 (Print) IS - 2192-5690 (Electronic) IS - 2192-5682 (Linking) VI - 12 IP - 2 DP - 2022 Mar TI - Diabetes Mellitus-A Risk Factor for the Development of Lumbar Disc Degeneration: A Retrospective Study of an Indian Population. PG - 215-220 LID - 10.1177/2192568220948035 [doi] AB - STUDY DESIGN: A retrospective study. OBJECTIVES: To determine the association between type-2 diabetes mellitus (T2DM) and the severity of lumbar disc degeneration disease (LDDD). METHODS: We included 199 patients with low back pain (LBP) who visited our hospital from 2016 to 2018. All patients were divided into 3 groups as per inclusion criteria. Group A, patients without DM (n = 75); group B, patients with controlled DM (n = 72); and group C, patients with uncontrolled DM (n = 52). The patients were further subdivided into group B1, DM duration 10 years (n = 34); group C1 DM duration 10 years (n = 24). Sex, age, body mass index, occupation, smoking history, alcohol use, and duration of T2DM were recorded. The severity of LDDD was evaluated using the 5-level Pfirrmann grading system. Operated patients' disc materials were sent for histological examination. RESULTS: Demographic data showed no difference among groups (P > 0.5), except age. Patients with DM showed more severe disc degeneration compared with patients without DM. The average Pfirrmann scores between groups A and B1 had no difference; groups B2, C1, and C2 showed higher average Pfirrmann scores than group A (P < 0.05). Groups B2 and C2 showed higher average Pfirrmann scores than groups B1 and C1 (P < 0.05). Groups C1 and C2 showed higher average Pfirrmann scores than groups B1 and B2 (P < 0.05). The severity of LDDD was significantly related to DM duration in both groups B and C (P < 0.05). DM groups showed increased disc apoptosis and matrix aggrecan fragmentation, disc glycosaminoglycan content and histological analysis were significantly different; the results are similar to Pfirrmann score results. CONCLUSIONS: DM duration >10 years and uncontrolled DM were risk factors for LDDD. FAU - Kakadiya, Ghanshyam AU - Kakadiya G AUID- ORCID: 0000-0002-0345-7407 AD - TNMC & BYL Nair Hospital, Mumbai, Maharashtra, India. FAU - Gandbhir, Viraj AU - Gandbhir V AD - TNMC & BYL Nair Hospital, Mumbai, Maharashtra, India. FAU - Soni, Yogesh AU - Soni Y AD - SSIMS, Bhilai, Chhatisgarh, India. FAU - Gohil, Kushal AU - Gohil K AD - Park Clinic, Kolkata, West Bengal, India. FAU - Shakya, Akash AU - Shakya A AD - ESI Hospital, Mumbai, Maharashtra, India. LA - eng PT - Journal Article DEP - 20200923 PL - England TA - Global Spine J JT - Global spine journal JID - 101596156 PMC - PMC8907643 OTO - NOTNLM OT - Diabetes mellitus OT - HbA1c OT - Lumbar disc degeneration disease OT - Pfirrmann score COIS- Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2020/09/24 06:00 MHDA- 2020/09/24 06:01 PMCR- 2020/09/23 CRDT- 2020/09/23 08:38 PHST- 2020/09/24 06:00 [pubmed] PHST- 2020/09/24 06:01 [medline] PHST- 2020/09/23 08:38 [entrez] PHST- 2020/09/23 00:00 [pmc-release] AID - 10.1177_2192568220948035 [pii] AID - 10.1177/2192568220948035 [doi] PST - ppublish SO - Global Spine J. 2022 Mar;12(2):215-220. doi: 10.1177/2192568220948035. Epub 2020 Sep 23.