PMID- 32965138
OWN - NLM
STAT- MEDLINE
DCOM- 20211129
LR  - 20220422
IS  - 1744-5078 (Electronic)
IS  - 0927-3948 (Linking)
VI  - 29
IP  - 2
DP  - 2021 Feb 17
TI  - HLA-DRB1*04:05 and HLA-DQB1*04:01: Alleles Potentially Associated with 
      Vogt-Koyanagi-Harada in Northern Thai Patients.
PG  - 260-263
LID - 10.1080/09273948.2020.1813315 [doi]
AB  - PURPOSE: To determine the frequency and association of alleles at human leukocyte 
      antigen (HLA)-DRB1 and HLA-DQB1 loci in VKH disease patients from Northern 
      Thailand. METHODS: A case-control study was conducted with three subject groups: 
      23 VKH patients, 20 patients with other uveitis entities, and 40 healthy blood 
      donors. HLA-DRB1 and HLA-DQB1 loci were analyzed and the frequency of HLA-DRB1 
      and HLA-DQB1 alleles was calculated by direct counting. The measure of 
      association was calculated by odds ratio (OR) and 95% confidence interval. 
      RESULTS: In VKH patients, the most prevalent allele was HLA-DRB1*04:05, found in 
      35% of patients and with the highest OR (42.13). HLA-DQB1*04:01 was the next most 
      prevalent, found in 23.91% of VKH patients. HLA-DQB1*05:02 was also detected in 
      23.91% of patients; however, a higher prevalence was observed in non-VKH and 
      healthy controls (30% and 35%, respectively). CONCLUSION: HLA-DRB1*04:05 and 
      HLA-DQB1*04:01 could be potential genetic markers for VKH.
FAU - Anukul, Nampeung
AU  - Anukul N
AUID- ORCID: 0000-0003-0873-7667
AD  - Division of Transfusion Science, Department of Medical Technology, Faculty of 
      Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.
FAU - Pathanapitoon, Kessara
AU  - Pathanapitoon K
AD  - Department of Ophthalmology, Faculty of Medicines, Chiang Mai University, Chiang 
      Mai, Thailand.
FAU - Leetrakool, Nipapan
AU  - Leetrakool N
AD  - Blood Bank Section, Maharaj Nakorn Chiang Mai Hospital, Faculty of Medicines, 
      Chiang Mai University, Chiang Mai, Thailand.
FAU - Guntiya, Tiphakorn
AU  - Guntiya T
AD  - Division of Transfusion Science, Department of Medical Technology, Faculty of 
      Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.
FAU - Wita, Ratsameetip
AU  - Wita R
AD  - Department of Computer Science, Faculty of Science, Chiang Mai University, Chiang 
      Mai, Thailand.
FAU - Palacajornsuk, Poonsub
AU  - Palacajornsuk P
AD  - Division of Transfusion Science, Department of Medical Technology, Faculty of 
      Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.
FAU - Klangsinsirikul, Phennapha
AU  - Klangsinsirikul P
AUID- ORCID: 0000-0003-4272-4229
AD  - Division of Transfusion Science, Department of Medical Technology, Faculty of 
      Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20200923
PL  - England
TA  - Ocul Immunol Inflamm
JT  - Ocular immunology and inflammation
JID - 9312169
RN  - 0 (Genetic Markers)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*04 antigen)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Autoimmunity/*genetics
MH  - Case-Control Studies
MH  - DNA/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Markers/genetics
MH  - HLA-DQ beta-Chains/genetics/immunology
MH  - HLA-DRB1 Chains/*genetics/immunology
MH  - Histocompatibility Testing
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Thailand/epidemiology
MH  - Uveomeningoencephalitic Syndrome/epidemiology/*genetics/immunology
MH  - Young Adult
OTO - NOTNLM
OT  - Human Leukocyte Antigen
OT  - Vogt-Koyanagi-Harada (VKH)
OT  - disease association
OT  - genetic marker
OT  - uveitis
EDAT- 2020/09/24 06:00
MHDA- 2021/11/30 06:00
CRDT- 2020/09/23 12:11
PHST- 2020/09/24 06:00 [pubmed]
PHST- 2021/11/30 06:00 [medline]
PHST- 2020/09/23 12:11 [entrez]
AID - 10.1080/09273948.2020.1813315 [doi]
PST - ppublish
SO  - Ocul Immunol Inflamm. 2021 Feb 17;29(2):260-263. doi: 
      10.1080/09273948.2020.1813315. Epub 2020 Sep 23.