PMID- 329672
OWN - NLM
STAT- MEDLINE
DCOM- 19770929
LR  - 20190626
IS  - 0002-9343 (Print)
IS  - 0002-9343 (Linking)
VI  - 63
IP  - 2
DP  - 1977 Aug
TI  - Evidence that Aspergillus fumigatus growing in the airway of man can be a potent 
      stimulus of specific and nonspecific IgE formation.
PG  - 257-62
AB  - Serum IgE levels in patients with allergic bronchopulmonary aspergillosis are 
      elevated but the degree of elevation varies markedly. Serum IgE levels in 
      patients with aspergillomas may be strikingly elevated or normal. Absorption of 
      serums with antigens of Aspergillus fumigatus combined with a solid phase 
      radioimmunoassay technic demonstrated that both immunoglobulin E (IgE) and 
      immunoglobulin G (IgG) antibody activity against A. fumigatus were markedly 
      reduced without a parallel reduction in serum total IgE. These results indicate 
      that the very high levels of serum IgE found in allergic bronchopulmonary 
      aspergillosis and aspergilloma are not all specific IgE. These results are 
      similar to those observed in rats infested with Nippostrongylus brasiliensis. An 
      explanation for the elevations of IgE levels in infestations with A. fumigatus 
      may be analogous to the postulate that parasite-produced materials may result in 
      T cell stimulatory factors for IgE-producing cells. Alternatively, A. fumigatus 
      organisms may produce materials that inhibit T suppressor lymphocytes.
FAU - Patterson, R
AU  - Patterson R
FAU - Rosenberg, M
AU  - Rosenberg M
FAU - Roberts, M
AU  - Roberts M
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Med
JT  - The American journal of medicine
JID - 0267200
RN  - 0 (Immunoglobulin G)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - VB0R961HZT (Prednisone)
SB  - IM
MH  - Aspergillosis/drug therapy/immunology
MH  - Aspergillus fumigatus/*growth & development/immunology
MH  - Bronchial Diseases/drug therapy/immunology
MH  - Humans
MH  - Immunoglobulin E/*biosynthesis
MH  - Immunoglobulin G/biosynthesis
MH  - Lung Diseases, Fungal/drug therapy/immunology
MH  - Prednisone/therapeutic use
MH  - Respiratory System/immunology/*microbiology
EDAT- 1977/08/01 00:00
MHDA- 1977/08/01 00:01
CRDT- 1977/08/01 00:00
PHST- 1977/08/01 00:00 [pubmed]
PHST- 1977/08/01 00:01 [medline]
PHST- 1977/08/01 00:00 [entrez]
AID - 0002-9343(77)90240-6 [pii]
AID - 10.1016/0002-9343(77)90240-6 [doi]
PST - ppublish
SO  - Am J Med. 1977 Aug;63(2):257-62. doi: 10.1016/0002-9343(77)90240-6.