PMID- 32967202
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201028
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 9
IP  - 9
DP  - 2020 Sep 21
TI  - Monocyte Chemoattractant Protein-1 Is an Independent Predictor of Coronary Artery 
      Ectasia in Patients with Acute Coronary Syndrome.
LID - 10.3390/jcm9093037 [doi]
LID - 3037
AB  - Our purpose was to assess a possible association of inflammatory, lipid and 
      mineral metabolism biomarkers with coronary artery ectasia (CAE) and to determine 
      a possible association of this with acute atherotrombotic events (AAT). We 
      studied 270 patients who underwent coronary angiography during an acute coronary 
      syndrome 6 months before. Plasma levels of several biomarkers were assessed, and 
      patients were followed during a median of 5.35 (3.88-6.65) years. Two 
      interventional cardiologists reviewed the coronary angiograms, diagnosing CAE 
      according to previously published criteria in 23 patients (8.5%). Multivariate 
      binary logistic regression analysis was used to search for independent predictors 
      of CAE. Multivariate analysis revealed that, aside from gender and a diagnosis of 
      dyslipidemia, only monocyte chemoattractant protein-1 (MCP-1) (OR = 2.25, 95%CI = 
      (1.35-3.76) for each increase of 100 pg/mL, p = 0.001) was independent predictor 
      of CAE, whereas mineral metabolism markers or proprotein convertase 
      subtilisin/kexin type 9 were not. Moreover, CAE was a strong predictor of AAT 
      during follow-up after adjustment for other clinically relevant variables (HR = 
      2.67, 95%CI = (1.22-5.82), p = 0.013). This is the first report showing that 
      MCP-1 is an independent predictor of CAE, suggesting that CAE and coronary artery 
      disease may share pathogenic mechanisms. Furthermore, CAE was associated with an 
      increased incidence of AAT.
FAU - Franco-Pelaez, Juan Antonio
AU  - Franco-Pelaez JA
AUID- ORCID: 0000-0001-5360-7066
AD  - Department of Cardiology, Instituto de Investigacion Sanitaria-Fundacion Jimenez 
      Diaz, 28040 Madrid, Spain.
AD  - Department of Medicine, Autonoma University, 28049 Madrid, Spain.
FAU - Martin-Reyes, Roberto
AU  - Martin-Reyes R
AD  - Department of Cardiology, Hospital La Luz, 28003 Madrid, Spain.
FAU - Pello-Lazaro, Ana Maria
AU  - Pello-Lazaro AM
AUID- ORCID: 0000-0002-5699-3422
AD  - Department of Cardiology, Instituto de Investigacion Sanitaria-Fundacion Jimenez 
      Diaz, 28040 Madrid, Spain.
AD  - Department of Medicine, Autonoma University, 28049 Madrid, Spain.
FAU - Acena, Alvaro
AU  - Acena A
AD  - Department of Cardiology, Instituto de Investigacion Sanitaria-Fundacion Jimenez 
      Diaz, 28040 Madrid, Spain.
AD  - Department of Medicine, Autonoma University, 28049 Madrid, Spain.
FAU - Lorenzo, Oscar
AU  - Lorenzo O
AD  - Department of Medicine, Autonoma University, 28049 Madrid, Spain.
AD  - Laboratory of Vascular Pathology, Instituto de Investigacion Sanitaria-Fundacion 
      Jimenez Diaz, 28040 Madrid, Spain.
FAU - Martin-Ventura, Jose Luis
AU  - Martin-Ventura JL
AD  - Department of Medicine, Autonoma University, 28049 Madrid, Spain.
AD  - Laboratory of Vascular Pathology, Instituto de Investigacion Sanitaria-Fundacion 
      Jimenez Diaz, 28040 Madrid, Spain.
AD  - Centro de Investigacion Biomedica en Red (CiberCV), 28029 Madrid, Spain.
AD  - Centro de Investigacion Biomedica en Red de Diabetes y Enfermedades Metabolicas 
      Asociadas (CIBERDEM), 28029 Madrid, Spain.
FAU - Blanco-Colio, Luis
AU  - Blanco-Colio L
AUID- ORCID: 0000-0002-1560-6609
AD  - Laboratory of Vascular Pathology, Instituto de Investigacion Sanitaria-Fundacion 
      Jimenez Diaz, 28040 Madrid, Spain.
AD  - Centro de Investigacion Biomedica en Red (CiberCV), 28029 Madrid, Spain.
FAU - Gonzalez-Casaus, Maria Luisa
AU  - Gonzalez-Casaus ML
AD  - Laboratory of Nephrology and Mineral Metabolism, Hospital Gomez-Ulla, 28047 
      Madrid, Spain.
FAU - Hernandez-Gonzalez, Ignacio
AU  - Hernandez-Gonzalez I
AD  - Department of Cardiology, Hospital Universitario Rio Hortega, 47012 Valladolid, 
      Spain.
FAU - Carda, Rocio
AU  - Carda R
AD  - Department of Cardiology, Instituto de Investigacion Sanitaria-Fundacion Jimenez 
      Diaz, 28040 Madrid, Spain.
AD  - Department of Medicine, Autonoma University, 28049 Madrid, Spain.
FAU - Martin-Mariscal, Maria Luisa
AU  - Martin-Mariscal ML
AD  - Department of Cardiology, Hospital Ruber Juan Bravo, 28006 Madrid, Spain.
FAU - Egido, Jesus
AU  - Egido J
AD  - Department of Medicine, Autonoma University, 28049 Madrid, Spain.
AD  - Laboratory of Vascular Pathology, Instituto de Investigacion Sanitaria-Fundacion 
      Jimenez Diaz, 28040 Madrid, Spain.
AD  - Centro de Investigacion Biomedica en Red de Diabetes y Enfermedades Metabolicas 
      Asociadas (CIBERDEM), 28029 Madrid, Spain.
AD  - Department of Nephrology, Instituto de Investigacion Sanitaria-Fundacion Jimenez 
      Diaz, 28040 Madrid, Spain.
FAU - Tunon, Jose
AU  - Tunon J
AUID- ORCID: 0000-0002-1373-0999
AD  - Department of Cardiology, Instituto de Investigacion Sanitaria-Fundacion Jimenez 
      Diaz, 28040 Madrid, Spain.
AD  - Department of Medicine, Autonoma University, 28049 Madrid, Spain.
AD  - Laboratory of Vascular Pathology, Instituto de Investigacion Sanitaria-Fundacion 
      Jimenez Diaz, 28040 Madrid, Spain.
AD  - Centro de Investigacion Biomedica en Red (CiberCV), 28029 Madrid, Spain.
LA  - eng
GR  - RD06/0014/0035/RECAVA/
GR  - PI05/0451, PI05/1497, PI05/52475, PI05/1043, PS09/01405, and PI10/00072, 
      PI14/01567, PI17/01615/Instituto de Investigaciones Sanitarias/
GR  - RD09/0076/ 00101/Instituto de Salud Carlos III FEDER/
PT  - Journal Article
DEP - 20200921
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC7563376
OTO - NOTNLM
OT  - acute atherotrombotic events
OT  - coronary artery disease
OT  - coronary artery ectasia
OT  - low-density lipoprotein
OT  - monocyte chemoattractant protein-1
COIS- J. Egido is lecturer for AbbVie laboratories. J. Tunon is lecturer and has 
      participated in advisory boards for Sanofi. The remaining authors have no 
      conflicts of interest. The funders had no role in study design, data collection 
      and analysis, decision to publish, or preparation of the manuscript.
EDAT- 2020/09/25 06:00
MHDA- 2020/09/25 06:01
PMCR- 2020/09/21
CRDT- 2020/09/24 01:01
PHST- 2020/09/08 00:00 [received]
PHST- 2020/09/14 00:00 [revised]
PHST- 2020/09/17 00:00 [accepted]
PHST- 2020/09/24 01:01 [entrez]
PHST- 2020/09/25 06:00 [pubmed]
PHST- 2020/09/25 06:01 [medline]
PHST- 2020/09/21 00:00 [pmc-release]
AID - jcm9093037 [pii]
AID - jcm-09-03037 [pii]
AID - 10.3390/jcm9093037 [doi]
PST - epublish
SO  - J Clin Med. 2020 Sep 21;9(9):3037. doi: 10.3390/jcm9093037.