PMID- 32967249
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240329
IS  - 2073-4360 (Electronic)
IS  - 2073-4360 (Linking)
VI  - 12
IP  - 9
DP  - 2020 Sep 21
TI  - Different Strategies for the Preparation of Galactose-Functionalized 
      Thermo-Responsive Nanogels with Potential as Smart Drug Delivery Systems.
LID - 10.3390/polym12092150 [doi]
LID - 2150
AB  - Different synthetic strategies were tested for the incorporation of galactose 
      molecules on thermoresponsive nanogels owing to their affinity for receptors 
      expressed in cancer cells. Three families of galactose-functionalized 
      poly(N-vinylcaprolactam) nanogels were prepared with the aim to control the 
      introduction of galactose-moieties into the core, the core-shell interface and 
      the shell. First and second of the above mentioned, were prepared via surfactant 
      free emulsion polymerization (SFEP) by a free-radical mechanism and the third 
      one, via SFEP/reversible addition-fragmentation chain transfer (RAFT) 
      polymerization. Synthetic recipes for the SFEP/free radical method included 
      besides N-vinylcaprolactam (NVCL), a shell forming poly(ethylene glycol) methyl 
      ether methacrylate (PEGMA), while the galactose (GAL) moiety was introduced via 
      6-O-acryloyl-1,2,:3,4-bis-O-(1-methyl-ethylidene)-alpha-(D)-galactopiranose (6-ABG, 
      protected GAL-monomer): nanogels I, or 2-lactobionamidoethyl methacrylate (LAMA, 
      GAL-monomer): nanogels II. For the SFEP/RAFT methodology 
      poly(2-lactobionamidoethyl methacrylate) as GAL macro-chain transfer agent (PLAMA 
      macro-CTA) was first prepared and on a following stage, the macro-CTA was 
      copolymerized with PEGMA and NVCL, nanogels III. The crosslinker ethylene glycol 
      dimethacrylate (EGDMA) was added in both methodologies for the polymer network 
      construction. Nanogel's sizes obtained resulted between 90 and 370 nm. With 
      higher content of PLAMA macro-CTA or GAL monomer in nanogels, a higher the 
      phase-transition temperature (T(VPT)) was observed with values ranging from 28 to 
      46  degrees C. The rho-parameter, calculated by the ratio of gyration and hydrodynamic 
      radii from static (SLS) and dynamic (DLS) light scattering measurements, and 
      transmission electron microscopy (TEM) micrographs suggest that core-shell 
      nanogels of flexible chains were obtained; in either spherical (nanogels II and 
      III) or hyperbranched (nanogels I) form.
FAU - Gonzalez-Ayon, Mirian A
AU  - Gonzalez-Ayon MA
AD  - Centro de Graduados e Investigacion en Quimica, Tecnologico Nacional de 
      Mexico/Instituto Tecnologico de Tijuana, Apartado Postal 1166, Tijuana 22454, 
      Mexico.
FAU - Licea-Claverie, Angel
AU  - Licea-Claverie A
AUID- ORCID: 0000-0002-0725-0980
AD  - Centro de Graduados e Investigacion en Quimica, Tecnologico Nacional de 
      Mexico/Instituto Tecnologico de Tijuana, Apartado Postal 1166, Tijuana 22454, 
      Mexico.
FAU - Sanudo-Barajas, J Adriana
AU  - Sanudo-Barajas JA
AUID- ORCID: 0000-0002-8467-8497
AD  - Centro de Investigacion en Alimentacion y Desarrollo, A. C. Carretera a El dorado 
      Km 5.5, Culiacan 80110, Mexico.
LA  - eng
GR  - CONACYT-CB2016-285419/Consejo Nacional de Ciencia y Tecnologia/
PT  - Journal Article
DEP - 20200921
PL  - Switzerland
TA  - Polymers (Basel)
JT  - Polymers
JID - 101545357
PMC - PMC7569999
OTO - NOTNLM
OT  - N-vinylcaprolactam
OT  - RAFT
OT  - SFEP
OT  - galactose-functionalized nanogels
OT  - thermoresponsive nanogels
COIS- The authors declare no conflict of interest.
EDAT- 2020/09/25 06:00
MHDA- 2020/09/25 06:01
PMCR- 2020/09/21
CRDT- 2020/09/24 01:01
PHST- 2020/08/10 00:00 [received]
PHST- 2020/09/04 00:00 [revised]
PHST- 2020/09/04 00:00 [accepted]
PHST- 2020/09/24 01:01 [entrez]
PHST- 2020/09/25 06:00 [pubmed]
PHST- 2020/09/25 06:01 [medline]
PHST- 2020/09/21 00:00 [pmc-release]
AID - polym12092150 [pii]
AID - polymers-12-02150 [pii]
AID - 10.3390/polym12092150 [doi]
PST - epublish
SO  - Polymers (Basel). 2020 Sep 21;12(9):2150. doi: 10.3390/polym12092150.