PMID- 32967492
OWN - NLM
STAT- MEDLINE
DCOM- 20220217
LR  - 20220217
IS  - 1369-1635 (Electronic)
IS  - 0953-7104 (Linking)
VI  - 32
IP  - 8
DP  - 2021 Nov 17
TI  - Comparison of antiplatelet antibody profiles between hepatitis C virus-associated 
      immune thrombocytopenia and primary immune thrombocytopenia.
PG  - 1043-1050
LID - 10.1080/09537104.2020.1820975 [doi]
AB  - Hepatitis C virus-associated immune thrombocytopenia (HCV-ITP) has been assumed 
      to be one of secondary ITP and associated with antiplatelet antibodies. This 
      study was to clarify the antibody profile in HCV-ITP compared with primary ITP. 
      We enrolled 55 HCV-ITP, 30 primary ITP, 11 Helicobacter pylori-ITP, 21 HCV 
      control, and 16 healthy volunteers. We reviewed their blood cell counts, 
      autoimmune markers, and spleen size. We used enzyme-linked immunosorbent assay 
      kit to detect the specific antibody to glycoproteins IIb/IIIa, Ia/IIa, Ib/IX, IV, 
      and human leukocyte antigen (HLA) class I. Compared with primary ITP patients, 
      HCV-ITP patients had an older age, lower white blood cell (WBC) count and fewer 
      presented with severe thrombocytopenia. The rate of positive antibody detection 
      was 63.6% for the HCV-ITP group higher than the rate of 40% for the primary ITP. 
      In the HCV control, antiplatelet antibodies were detected in 38.1% patients and 
      no one had more than two types of antibodies. The antiplatelet antibodies 
      correlated to severer thrombocytopenia. An HLA class I antibody was associated 
      with lower WBCs and larger spleen. In conclusion, HCV-ITP patients had a high 
      rate of positive antiplatelet antibody. The antibodies were associated with not 
      only lower platelets but also leukopenia and splenomegaly.
FAU - Huang, Cih-En
AU  - Huang CE
AUID- ORCID: 0000-0001-5921-5346
AD  - Division of Hematology and Oncology, Department of Medicine, Chang Gung Memorial 
      Hospital, Chiayi, Taiwan.
AD  - Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, 
      Taiwan.
FAU - Chen, Wei-Ming
AU  - Chen WM
AD  - Division of Gastroenterology and Hepatology, Department of Medicine, Chang Gung 
      Memorial Hospital, Chiayi, Taiwan.
AD  - College of Medicine, Chang Gung University, Taoyuan, Taiwan.
AD  - Department of Health and Nutrition, Chia Nan University of Pharmacy and Science, 
      Tainan, Taiwan.
FAU - Wu, Yu-Ying
AU  - Wu YY
AD  - Division of Hematology and Oncology, Department of Medicine, Chang Gung Memorial 
      Hospital, Chiayi, Taiwan.
FAU - Shen, Chien-Heng
AU  - Shen CH
AD  - Division of Gastroenterology and Hepatology, Department of Medicine, Chang Gung 
      Memorial Hospital, Chiayi, Taiwan.
FAU - Hsu, Chia-Chen
AU  - Hsu CC
AD  - Division of Hematology and Oncology, Department of Medicine, Chang Gung Memorial 
      Hospital, Chiayi, Taiwan.
FAU - Li, Chian-Pei
AU  - Li CP
AD  - Division of Hematology and Oncology, Department of Medicine, Chang Gung Memorial 
      Hospital, Chiayi, Taiwan.
FAU - Chen, Min-Chi
AU  - Chen MC
AD  - Division of Hematology and Oncology, Department of Medicine, Chang Gung Memorial 
      Hospital, Chiayi, Taiwan.
AD  - Department of Public Health and Biostatistics Consulting Center, Chang Gung 
      University, Taoyuan, Taiwan.
FAU - Chang, Jung-Jung
AU  - Chang JJ
AD  - Division of Cardiology, Department of Medicine, Chang Gung Memorial Hospital, 
      Chiayi, Taiwan.
FAU - Chen, Yi-Yang
AU  - Chen YY
AD  - Division of Hematology and Oncology, Department of Medicine, Chang Gung Memorial 
      Hospital, Chiayi, Taiwan.
FAU - Lu, Chang-Hsien
AU  - Lu CH
AD  - Division of Hematology and Oncology, Department of Medicine, Chang Gung Memorial 
      Hospital, Chiayi, Taiwan.
FAU - Shi, Chung-Sheng
AU  - Shi CS
AD  - Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, 
      Taiwan.
AD  - Division of Urology, Department of Surgery, Chang Gung Memorial Hospital, Chiayi, 
      Taiwan.
FAU - Chen, Chih-Cheng
AU  - Chen CC
AUID- ORCID: 0000-0002-6794-7229
AD  - Division of Hematology and Oncology, Department of Medicine, Chang Gung Memorial 
      Hospital, Chiayi, Taiwan.
AD  - College of Medicine, Chang Gung University, Taoyuan, Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20200923
PL  - England
TA  - Platelets
JT  - Platelets
JID - 9208117
SB  - IM
MH  - Aged
MH  - Blood Platelets/*metabolism
MH  - Case-Control Studies
MH  - Female
MH  - Hepacivirus/*immunology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Purpura, Thrombocytopenic, Idiopathic/*blood
MH  - Thrombocytopenia/*blood
OTO - NOTNLM
OT  - Antiplatelet antibody
OT  - glycoprotein
OT  - hepatitis C virus
OT  - human leukocyte antigen
OT  - immune thrombocytopenia
EDAT- 2020/09/25 06:00
MHDA- 2022/02/19 06:00
CRDT- 2020/09/24 05:24
PHST- 2020/09/25 06:00 [pubmed]
PHST- 2022/02/19 06:00 [medline]
PHST- 2020/09/24 05:24 [entrez]
AID - 10.1080/09537104.2020.1820975 [doi]
PST - ppublish
SO  - Platelets. 2021 Nov 17;32(8):1043-1050. doi: 10.1080/09537104.2020.1820975. Epub 
      2020 Sep 23.