PMID- 32967495
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20240113
IS  - 1473-2300 (Electronic)
IS  - 0300-0605 (Print)
IS  - 0300-0605 (Linking)
VI  - 48
IP  - 9
DP  - 2020 Sep
TI  - Effect of intersphincteric fistula tract ligation versus anal fistulectomy on 
      pain scores and serum levels of vascular endothelial growth factor and 
      interleukin-2 in patients with simple anal fistulas.
PG  - 300060520949072
LID - 10.1177/0300060520949072 [doi]
LID - 0300060520949072
AB  - OBJECTIVE: This study was performed to explore the effects of ligation of the 
      intersphincteric fistula tract (LIFT) on pain scores and serum levels of vascular 
      endothelial growth factor (VEGF) and interleukin (IL)-2 in patients with simple 
      anal fistulas. METHODS: Ninety patients with simple anal fistulas were evenly 
      randomized into a study group (treated with LIFT) and a control group (treated 
      with traditional anal fistulectomy) according to a random number table. The 
      surgical outcomes, basic operation conditions (operation time, hospital stay, and 
      anal continence), and postoperative wound healing rates were compared between the 
      two groups. RESULTS: The study group had significantly better operation 
      conditions (better anal continence and shorter length of hospital stay), a higher 
      postoperative wound healing rate, lower pain scores, higher VEGF and IL-2 levels, 
      and higher overall efficacy rate than the control group. However, the incidence 
      of postoperative complications was not significantly different between the two 
      groups. CONCLUSIONS: Patients who underwent LIFT had better surgical outcomes, 
      higher wound healing rates, better anal continence, a shorter length of hospital 
      stay, and less severe postoperative pain than those who underwent simple anal 
      fistulectomy. Increased levels of VEGF and IL-2 after surgery may promote wound 
      healing.
FAU - Dong, Xin
AU  - Dong X
AD  - Anorectal Department, Dongying People's Hospital, Dongying, Shandong, China.
FAU - Jia, Zhanbo
AU  - Jia Z
AUID- ORCID: 0000-0001-7665-3604
AD  - Anorectal Department, Dongying People's Hospital, Dongying, Shandong, China.
FAU - Yu, Bianfang
AU  - Yu B
AD  - Anorectal Department, Dongying People's Hospital, Dongying, Shandong, China.
FAU - Zhang, Xuebin
AU  - Zhang X
AD  - Anorectal Department, Dongying People's Hospital, Dongying, Shandong, China.
FAU - Xu, Fagang
AU  - Xu F
AD  - Anorectal Department, Dongying People's Hospital, Dongying, Shandong, China.
FAU - Tan, Longtao
AU  - Tan L
AD  - Anorectal Department, Dongying People's Hospital, Dongying, Shandong, China.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Retracted Publication
PL  - England
TA  - J Int Med Res
JT  - The Journal of international medical research
JID - 0346411
RN  - 0 (Interleukin-2)
RN  - 0 (Vascular Endothelial Growth Factor A)
SB  - IM
RIN - J Int Med Res. 2024 Jan;52(1):3000605241228165. PMID: 38217421
MH  - Anal Canal/surgery
MH  - Humans
MH  - *Interleukin-2
MH  - Ligation
MH  - *Rectal Fistula/surgery
MH  - Recurrence
MH  - Treatment Outcome
MH  - Vascular Endothelial Growth Factor A
PMC - PMC7521059
OTO - NOTNLM
OT  - Simple anal fistula
OT  - anal fistulectomy
OT  - interleukin-2
OT  - ligation of the intersphincteric fistula tract
OT  - vascular endothelial growth factor
OT  - wound healing
EDAT- 2020/09/25 06:00
MHDA- 2021/05/15 06:00
PMCR- 2020/09/24
CRDT- 2020/09/24 05:24
PHST- 2020/09/24 05:24 [entrez]
PHST- 2020/09/25 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
PHST- 2020/09/24 00:00 [pmc-release]
AID - 10.1177_0300060520949072 [pii]
AID - 10.1177/0300060520949072 [doi]
PST - ppublish
SO  - J Int Med Res. 2020 Sep;48(9):300060520949072. doi: 10.1177/0300060520949072.