PMID- 32968204 OWN - NLM STAT- MEDLINE DCOM- 20210802 LR - 20221207 IS - 1435-232X (Electronic) IS - 1434-5161 (Linking) VI - 66 IP - 4 DP - 2021 Apr TI - Association of ABCG1 gene methylation and its dynamic change status with incident type 2 diabetes mellitus: the Rural Chinese Cohort Study. PG - 347-357 LID - 10.1038/s10038-020-00848-z [doi] AB - To explore whether DNA methylation of the ATP-binding cassette G1 (ABCG1) gene and its dynamic change are associated with incident type 2 diabetes mellitus (T2DM). We conducted a nested case-control study with 286 pairs of T2DM cases and matched controls nested in the Rural Chinese Cohort Study. Conditional logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for incident T2DM risk according to ABCG1 methylation level at baseline and its dynamic change at follow-up examination. Spearman's rank correlation coefficients were used to analyze the association between ABCG1 methylation and its possible risk factors in the control group. We found that T2DM risk increased by 16% (OR = 1.16, 95% CI = 1.02-1.31) with each 1% increase in DNA methylation levels of the ABCG1 loci CpG13 and CpG14. DNA methylation change of the ABCG1 locus CpG15 during the 6-year follow-up was associated with increased T2DM risk: T2DM risk increased by 78% in the upper tertile group (methylation gain >/=5%) versus lower tertile group (methylation gain <1%) (OR = 1.78, 95% CI = 1.01-3.15). Furthermore, body mass index was positively correlated with the DNA methylation level of the ABCG1 loci CpG13, CpG14 and CpG15. In conclusion, DNA methylation levels of the ABCG1 loci CpG13 and CpG14 and the methylation gain of locus CpG15 were positively associated with incident T2DM risk, which may suggest a possible etiologic pattern for T2DM and potentially improve T2DM prediction in rural Chinese people. FAU - Qie, Ranran AU - Qie R AD - Department of Biostatistics and Epidemiology, School of Public Health, Shenzhen Univerity Health Science Center, Shenzhen, PR China. FAU - Chen, Qing AU - Chen Q AD - Department of Mental Health, Bao'an Chronic Diseases Prevent and Cure Hospital, Shenzhen, PR China. FAU - Wang, Tieqiang AU - Wang T AD - Key Lab of Epidemiology, Department of Infectious Disease Control and Prevention, Shenzhen Guangming District Center for Disease Control and Prevention, Shenzhen, PR China. FAU - Chen, Xiaoliang AU - Chen X AD - Key Lab of Epidemiology, Department of Chronic Disease Control and Prevention, Shenzhen Guangming District Center for Disease Control and Prevention, Shenzhen, PR China. FAU - Wang, Jian AU - Wang J AD - Study Team of Shenzhen's Sanming Project, The Affiliated Luohu Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, PR China. FAU - Cheng, Ruirong AU - Cheng R AD - Study Team of Shenzhen's Sanming Project, The Affiliated Luohu Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, PR China. FAU - Lin, Jinchun AU - Lin J AD - Study Team of Shenzhen's Sanming Project, The Affiliated Luohu Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, PR China. FAU - Zhao, Yang AU - Zhao Y AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. FAU - Liu, Dechen AU - Liu D AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. FAU - Qin, Pei AU - Qin P AD - Department of Biostatistics and Epidemiology, School of Public Health, Shenzhen Univerity Health Science Center, Shenzhen, PR China. FAU - Cheng, Cheng AU - Cheng C AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. FAU - Liu, Leilei AU - Liu L AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. FAU - Li, Quanman AU - Li Q AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. FAU - Guo, Chunmei AU - Guo C AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. FAU - Zhou, Qionggui AU - Zhou Q AD - Department of Biostatistics and Epidemiology, School of Public Health, Shenzhen Univerity Health Science Center, Shenzhen, PR China. FAU - Tian, Gang AU - Tian G AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. FAU - Han, Minghui AU - Han M AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. FAU - Huang, Shengbing AU - Huang S AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. FAU - Zhang, Yanyan AU - Zhang Y AD - Department of Biostatistics and Epidemiology, School of Public Health, Shenzhen Univerity Health Science Center, Shenzhen, PR China. FAU - Wu, Xiaoyan AU - Wu X AD - Department of Biostatistics and Epidemiology, School of Public Health, Shenzhen Univerity Health Science Center, Shenzhen, PR China. FAU - Wu, Yuying AU - Wu Y AD - Department of Biostatistics and Epidemiology, School of Public Health, Shenzhen Univerity Health Science Center, Shenzhen, PR China. FAU - Li, Yang AU - Li Y AD - Department of Biostatistics and Epidemiology, School of Public Health, Shenzhen Univerity Health Science Center, Shenzhen, PR China. FAU - Yang, Xingjin AU - Yang X AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. FAU - Zhao, Yang AU - Zhao Y AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. FAU - Feng, Yifei AU - Feng Y AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. FAU - Hu, Dongsheng AU - Hu D AD - Department of Biostatistics and Epidemiology, School of Public Health, Shenzhen Univerity Health Science Center, Shenzhen, PR China. AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. FAU - Zhang, Ming AU - Zhang M AUID- ORCID: 0000-0002-2923-5335 AD - Department of Biostatistics and Epidemiology, School of Public Health, Shenzhen Univerity Health Science Center, Shenzhen, PR China. zhangming@szu.edu.cn. LA - eng GR - 81402752 and 81673260/National Natural Science Foundation of China (National Science Foundation of China)/ GR - 81373074, 81402752 and 81673260/National Natural Science Foundation of China (National Science Foundation of China)/ PT - Journal Article DEP - 20200923 PL - England TA - J Hum Genet JT - Journal of human genetics JID - 9808008 RN - 0 (ABCG1 protein, human) RN - 0 (ATP Binding Cassette Transporter, Subfamily G, Member 1) RN - 0 (Blood Glucose) SB - IM MH - ATP Binding Cassette Transporter, Subfamily G, Member 1/*genetics MH - Asian People/*genetics MH - Blood Glucose/analysis MH - Body Mass Index MH - Case-Control Studies MH - China MH - Cohort Studies MH - *DNA Methylation MH - Diabetes Mellitus, Type 2/*epidemiology/*genetics/pathology MH - Female MH - Humans MH - Male MH - Middle Aged MH - Risk Factors EDAT- 2020/09/25 06:00 MHDA- 2021/08/03 06:00 CRDT- 2020/09/24 05:31 PHST- 2020/05/26 00:00 [received] PHST- 2020/09/14 00:00 [accepted] PHST- 2020/09/13 00:00 [revised] PHST- 2020/09/25 06:00 [pubmed] PHST- 2021/08/03 06:00 [medline] PHST- 2020/09/24 05:31 [entrez] AID - 10.1038/s10038-020-00848-z [pii] AID - 10.1038/s10038-020-00848-z [doi] PST - ppublish SO - J Hum Genet. 2021 Apr;66(4):347-357. doi: 10.1038/s10038-020-00848-z. Epub 2020 Sep 23.