PMID- 32969095
OWN - NLM
STAT- MEDLINE
DCOM- 20210621
LR  - 20210621
IS  - 1097-0347 (Electronic)
IS  - 1043-3074 (Linking)
VI  - 43
IP  - 1
DP  - 2021 Jan
TI  - Human papillomavirus oropharynx carcinoma: Aggressive de-escalation of adjuvant 
      therapy.
PG  - 229-237
LID - 10.1002/hed.26477 [doi]
AB  - BACKGROUND: Aggressive dose de-escalated adjuvant radiation therapy (RT) in 
      patients with human papillomavirus-associated oropharyngeal squamous cell 
      carcinoma (HPV(+)OPSCC). METHODS: Patients with HPV(+)OPSCC on a phase II 
      clinical trial of primary surgery and neck dissection followed by dose 
      de-escalated RT (N = 79) were compared with a cohort of patients who received 
      standard adjuvant therapy (N = 115). Local recurrence-free, regional 
      recurrence-free, distant metastases-free survival, and progression-free survival 
      (PFS) were assessed. RESULTS: Of 194 patients, 23 experienced progression at a 
      median of 1.1 years following surgery (interquartile range [IQR] 0.7-2.0; range 
      0.3-5.4); 10 patients in the de-escalated cohort and 13 patients in the standard 
      cohort. The 3-year PFS rate for the de-escalated cohort was 87%, and in the 
      standard cohort was 90% (hazard ratio [HR] 1.18, 95% confidence interval (CI) 
      [0.50-2.75]). CONCLUSION: Patients with HPV(+)OPSCC who undergo surgical 
      resection and neck dissection and meet criteria for adjuvant therapy can undergo 
      aggressive dose de-escalation of RT without increasing risk of progression 
      locally, regionally or at distant sites.
CI  - (c) 2020 Wiley Periodicals LLC.
FAU - Moore, Eric J
AU  - Moore EJ
AUID- ORCID: 0000-0003-1103-6212
AD  - Department of Otolaryngology - Head and Neck Surgery, Mayo Clinic, Rochester, 
      Minnesota, USA.
FAU - Van Abel, Kathryn M
AU  - Van Abel KM
AUID- ORCID: 0000-0003-0513-4203
AD  - Department of Otolaryngology - Head and Neck Surgery, Mayo Clinic, Rochester, 
      Minnesota, USA.
FAU - Routman, David M
AU  - Routman DM
AD  - Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, USA.
FAU - Lohse, Christine M
AU  - Lohse CM
AD  - Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
FAU - Price, Katharine A R
AU  - Price KAR
AD  - Department of Medical Oncology, Mayo Clinic, Rochester, Minnesota, USA.
FAU - Neben-Wittich, Michelle
AU  - Neben-Wittich M
AD  - Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, USA.
FAU - Chintakuntlawar, Ashish V
AU  - Chintakuntlawar AV
AD  - Department of Medical Oncology, Mayo Clinic, Rochester, Minnesota, USA.
FAU - Price, Daniel L
AU  - Price DL
AD  - Department of Otolaryngology - Head and Neck Surgery, Mayo Clinic, Rochester, 
      Minnesota, USA.
FAU - Kasperbauer, Jan L
AU  - Kasperbauer JL
AD  - Department of Pathology, Mayo Clinic, Rochester, Minnesota, USA.
FAU - Garcia, Joaquin J
AU  - Garcia JJ
AD  - Department of Pathology, Mayo Clinic, Rochester, Minnesota, USA.
FAU - Hinni, Michael L
AU  - Hinni ML
AD  - Department of Otolaryngology - Head and Neck Surgery, Mayo Clinic, Scottsdale, 
      Arizona, USA.
FAU - Patel, Samir H
AU  - Patel SH
AD  - Department of Radiation Oncology, Mayo Clinic, Scottsdale, Arizona, USA.
FAU - Janus, Jeffrey R
AU  - Janus JR
AD  - Department of Otolaryngology - Head and Neck Surgery, Mayo Clinic, Jacksonville, 
      Florida, USA.
FAU - Foote, Robert L
AU  - Foote RL
AD  - Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, USA.
FAU - Ma, Dan J
AU  - Ma DJ
AD  - Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, USA.
LA  - eng
PT  - Journal Article
DEP - 20200923
PL  - United States
TA  - Head Neck
JT  - Head & neck
JID - 8902541
SB  - IM
MH  - *Alphapapillomavirus
MH  - *Carcinoma, Squamous Cell/therapy
MH  - *Head and Neck Neoplasms
MH  - Humans
MH  - *Oropharyngeal Neoplasms/therapy
MH  - Oropharynx
MH  - Papillomaviridae
MH  - *Papillomavirus Infections
OTO - NOTNLM
OT  - HPV
OT  - TORS
OT  - de-escalation
OT  - oropharyngeal cancer
OT  - oropharynx
OT  - squamous cell carcinoma
EDAT- 2020/09/25 06:00
MHDA- 2021/06/22 06:00
CRDT- 2020/09/24 05:38
PHST- 2020/05/29 00:00 [received]
PHST- 2020/07/24 00:00 [revised]
PHST- 2020/09/09 00:00 [accepted]
PHST- 2020/09/25 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2020/09/24 05:38 [entrez]
AID - 10.1002/hed.26477 [doi]
PST - ppublish
SO  - Head Neck. 2021 Jan;43(1):229-237. doi: 10.1002/hed.26477. Epub 2020 Sep 23.