PMID- 32969458
OWN - NLM
STAT- MEDLINE
DCOM- 20210428
LR  - 20210428
IS  - 2050-7518 (Electronic)
IS  - 2050-750X (Linking)
VI  - 8
IP  - 40
DP  - 2020 Oct 21
TI  - Smart microneedle patches for rapid, and painless transdermal insulin delivery.
PG  - 9335-9342
LID - 10.1039/d0tb01822h [doi]
AB  - Insulin administration at mealtimes for the control of postprandial glucose is a 
      major part of basal-bolus insulin therapy; however, painful subcutaneous (SC) 
      injections lead to poor patient compliance. The microneedle (MN) patch, which 
      allows painless transdermal drug delivery, is a promising substitute; however, it 
      remains a big challenge to deliver insulin as rapidly as by SC injection. Here a 
      novel MN patch is designed in which the MNs are coated with 
      insulin/poly-l-glutamic acid (PGA) layer-by-layer (LBL) films at pH 3.0. This 
      coating is pH-sensitive because the net charge of insulin turns from positive to 
      negative when the pH increases from 3.0 to 7.4. As a result, when transferred to 
      pH 7.4 media, e.g., when inserted into skin, the coating dissociates instantly 
      and releases insulin rapidly. A brief epidermal application (<1 min) of the 
      coated MNs is enough for complete film dissociation. More importantly, the coated 
      MN patch exhibits a pharmacokinetic and a pharmacodynamic profile comparable to 
      that of insulin administrated by SC injection, suggesting the coated MN patch can 
      deliver insulin as rapidly as the SC injection. In addition, the patch exhibits 
      excellent biocompatibility and storage stability. The new MN patch is expected to 
      become a painless, convenient method for the control of postprandial glucose.
FAU - Wang, Yuanpeng
AU  - Wang Y
AUID- ORCID: 0000-0002-2724-8765
AD  - Key Laboratory of Functional Polymer Materials and State Key Laboratory of 
      Medicinal Chemical Biology, Institute of Polymer Chemistry, College of Chemistry, 
      Nankai University, Tianjin 300071, China. yingguan@nankai.edu.cn 
      yongjunzhang@nankai.edu.cn.
FAU - Wang, Haozheng
AU  - Wang H
AUID- ORCID: 0000-0001-6373-8967
AD  - Key Laboratory of Functional Polymer Materials and State Key Laboratory of 
      Medicinal Chemical Biology, Institute of Polymer Chemistry, College of Chemistry, 
      Nankai University, Tianjin 300071, China. yingguan@nankai.edu.cn 
      yongjunzhang@nankai.edu.cn.
FAU - Zhu, X X
AU  - Zhu XX
AUID- ORCID: 0000-0003-0828-299X
AD  - Departement de Chimie, Universite de Montreal, C.P. 6128, Succ. Centre-ville, 
      Montreal, QC H3C 3J7, Canada.
FAU - Guan, Ying
AU  - Guan Y
AUID- ORCID: 0000-0002-2950-0100
AD  - Key Laboratory of Functional Polymer Materials and State Key Laboratory of 
      Medicinal Chemical Biology, Institute of Polymer Chemistry, College of Chemistry, 
      Nankai University, Tianjin 300071, China. yingguan@nankai.edu.cn 
      yongjunzhang@nankai.edu.cn.
FAU - Zhang, Yongjun
AU  - Zhang Y
AUID- ORCID: 0000-0002-1079-4137
AD  - Key Laboratory of Functional Polymer Materials and State Key Laboratory of 
      Medicinal Chemical Biology, Institute of Polymer Chemistry, College of Chemistry, 
      Nankai University, Tianjin 300071, China. yingguan@nankai.edu.cn 
      yongjunzhang@nankai.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Mater Chem B
JT  - Journal of materials chemistry. B
JID - 101598493
RN  - 0 (Insulin, Regular, Human)
RN  - 9011-14-7 (Polymethyl Methacrylate)
SB  - IM
MH  - Administration, Cutaneous
MH  - Animals
MH  - Diabetes Mellitus, Experimental/drug therapy
MH  - Drug Delivery Systems/instrumentation/*methods
MH  - Humans
MH  - Insulin, Regular, Human/*administration & dosage/therapeutic use
MH  - Male
MH  - Microinjections/instrumentation/*methods
MH  - *Needles
MH  - Polymethyl Methacrylate/chemistry/toxicity
MH  - Rats, Sprague-Dawley
MH  - Skin/metabolism
MH  - Swine
EDAT- 2020/09/25 06:00
MHDA- 2021/04/29 06:00
CRDT- 2020/09/24 08:49
PHST- 2020/09/25 06:00 [pubmed]
PHST- 2021/04/29 06:00 [medline]
PHST- 2020/09/24 08:49 [entrez]
AID - 10.1039/d0tb01822h [doi]
PST - ppublish
SO  - J Mater Chem B. 2020 Oct 21;8(40):9335-9342. doi: 10.1039/d0tb01822h.