PMID- 3296972
OWN - NLM
STAT- MEDLINE
DCOM- 19870629
LR  - 20190514
IS  - 0003-4932 (Print)
IS  - 1528-1140 (Electronic)
IS  - 0003-4932 (Linking)
VI  - 205
IP  - 6
DP  - 1987 Jun
TI  - A successful cardiac transplantation program using combined university and 
      community resources.
PG  - 719-26
AB  - From August 1984 to August 1986, 75 patients with end-stage heart disease and 
      cardiac failure were evaluated. Twenty-five patients received orthotopic cardiac 
      transplants from donors as far away as 1300 miles with an ischemic time of less 
      than 4 hours. Seventeen of 25 patients are alive 3-24 months after 
      transplantation. Evidence of rejection was seen in each patient. Twelve patients 
      had mild, easily controlled rejection; 13 patients had severe rejection averaging 
      3.1 episodes per patient. The initial immunosuppressive regimen included 
      cyclosporine and prednisone. To decrease complications related to high dose 
      steroids, azathioprine has recently been added to our maintenance regimen to 
      lessen steroid requirements. Acute rejection episodes were treated with 500-1000 
      mg of methylprednisolone for 3 days; antithymocyte globulin or the murine 
      monoclonal antibody, OKT3, was added for severe or resistant rejection episodes. 
      Three patients died of rejection, and two patients died of infection. Seventeen 
      of 18 survivors are New York Heart Association (NYHA) Class I; 15 patients have 
      returned to employment or full activity. Because of new developments in support 
      of transplant candidates and treatment of complications, as well as the 
      introduction of cyclosporine, orthotopic cardiac transplantation has become an 
      effective treatment for end-stage heart disease.
FAU - Gray, L A Jr
AU  - Gray LA Jr
FAU - Slater, A D
AU  - Slater AD
FAU - Klein, J B
AU  - Klein JB
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann Surg
JT  - Annals of surgery
JID - 0372354
SB  - IM
MH  - Costs and Cost Analysis
MH  - *Heart Transplantation
MH  - Humans
MH  - Kentucky
MH  - Methods
MH  - Prognosis
PMC - PMC1493080
EDAT- 1987/06/01 00:00
MHDA- 2001/03/28 10:01
PMCR- 1987/12/01
CRDT- 1987/06/01 00:00
PHST- 1987/06/01 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1987/06/01 00:00 [entrez]
PHST- 1987/12/01 00:00 [pmc-release]
AID - 10.1097/00000658-198706000-00014 [doi]
PST - ppublish
SO  - Ann Surg. 1987 Jun;205(6):719-26. doi: 10.1097/00000658-198706000-00014.