PMID- 32970882
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20210514
IS  - 1522-2594 (Electronic)
IS  - 0740-3194 (Linking)
VI  - 85
IP  - 3
DP  - 2021 Mar
TI  - Frequency-stabilized chemical exchange saturation transfer imaging with real-time 
      free-induction-decay readout.
PG  - 1322-1334
LID - 10.1002/mrm.28513 [doi]
AB  - PURPOSE: To correct the temporal B(0) drift in chemical exchange saturation 
      transfer (CEST) imaging in real-time with extra free-induction-decay (FID) 
      readout. THEORY AND METHODS: The frequency stabilization module of the recently 
      proposed frequency-stabilized CEST (FS-CEST) sequence was further simplified by 
      replacing the original three k-space lines of gradient-echo (GRE) readout with a 
      single k-space line of FID readout. The B(0) drift was quantified using the phase 
      difference between the odd and even parts of the FID signal in the frequency 
      stabilization module and then used to update the B(0) frequency in the succeeding 
      modules. The proposed FS-CEST sequence with FID readout (FID FS-CEST) was 
      validated in phantoms and 16 human subjects on cross-vendor scanners. RESULTS: In 
      the Siemens experiments, the FID FS-CEST sequence successfully corrected the 
      user-induced B(0) drift, generating consistent amide proton transfer-weighted 
      (APTw) images and magnetization transfer ratio asymmetry (MTR(asym) ) spectra 
      with those from the non-frequency-stabilized CEST (NFS-CEST) sequence without 
      B(0) drift. In the Philips experiments, the FID FS-CEST sequence produced more 
      stable APTw images and MTR(asym) spectra than the NFS-CEST sequence in the 
      presence of practical B(0) drift. Quantitatively, the SD of the APTw signal 
      values in the deep gray matter from 15 subjects was 0.26% for the FID FS-CEST 
      sequence compared to 1.03% for the NFS-CEST sequences, with the fluctuations 
      reduced by nearly three-quarters. CONCLUSIONS: The proposed FS-CEST sequence with 
      FID readout can effectively correct the temporal B(0) drift on cross-vendor 
      scanners.
CI  - (c) 2020 International Society for Magnetic Resonance in Medicine.
FAU - Liu, Ruibin
AU  - Liu R
AUID- ORCID: 0000-0003-4273-155X
AD  - Key Laboratory for Biomedical Engineering of Ministry of Education, Department of 
      Biomedical Engineering, College of Biomedical Engineering & Instrument Science, 
      Zhejiang University, Hangzhou, Zhejiang, China.
FAU - Zhang, Hongxi
AU  - Zhang H
AD  - Department of Radiology, Children's Hospital, Zhejiang University School of 
      Medicine, Hangzhou, Zhejiang, China.
FAU - Qian, Yue
AU  - Qian Y
AD  - Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University School of 
      Medicine, Hangzhou, Zhejiang, China.
FAU - Hsu, Yi-Cheng
AU  - Hsu YC
AD  - MR Collaboration, Siemens Healthcare Ltd., Shanghai, China.
FAU - Fu, Caixia
AU  - Fu C
AD  - Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China.
FAU - Sun, Yi
AU  - Sun Y
AD  - MR Collaboration, Siemens Healthcare Ltd., Shanghai, China.
FAU - Wu, Dan
AU  - Wu D
AUID- ORCID: 0000-0002-9303-5821
AD  - Key Laboratory for Biomedical Engineering of Ministry of Education, Department of 
      Biomedical Engineering, College of Biomedical Engineering & Instrument Science, 
      Zhejiang University, Hangzhou, Zhejiang, China.
FAU - Zhang, Yi
AU  - Zhang Y
AUID- ORCID: 0000-0001-8738-1851
AD  - Key Laboratory for Biomedical Engineering of Ministry of Education, Department of 
      Biomedical Engineering, College of Biomedical Engineering & Instrument Science, 
      Zhejiang University, Hangzhou, Zhejiang, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200924
PL  - United States
TA  - Magn Reson Med
JT  - Magnetic resonance in medicine
JID - 8505245
RN  - 0 (Amides)
RN  - 0 (Protons)
SB  - IM
MH  - Amides
MH  - Humans
MH  - *Magnetic Resonance Imaging
MH  - Phantoms, Imaging
MH  - *Protons
OTO - NOTNLM
OT  - chemical exchange saturation transfer (CEST)
OT  - free-induction-decay (FID) readout
OT  - frequency stabilization
OT  - temporal B0 drift
EDAT- 2020/09/25 06:00
MHDA- 2021/05/15 06:00
CRDT- 2020/09/24 17:15
PHST- 2020/05/09 00:00 [received]
PHST- 2020/08/17 00:00 [revised]
PHST- 2020/08/17 00:00 [accepted]
PHST- 2020/09/25 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
PHST- 2020/09/24 17:15 [entrez]
AID - 10.1002/mrm.28513 [doi]
PST - ppublish
SO  - Magn Reson Med. 2021 Mar;85(3):1322-1334. doi: 10.1002/mrm.28513. Epub 2020 Sep 
      24.