PMID- 32971236 OWN - NLM STAT- MEDLINE DCOM- 20211020 LR - 20211020 IS - 1873-1708 (Electronic) IS - 0890-6238 (Linking) VI - 98 DP - 2020 Dec TI - Essential trace elements in umbilical cord tissue and risk for neural tube defects. PG - 149-156 LID - S0890-6238(20)30211-2 [pii] LID - 10.1016/j.reprotox.2020.09.007 [doi] AB - Deficient or excessive quantities of essential trace elements (ETEs)(1) in the fetal environment can compromise developmental processes. We investigated whether concentrations of zinc (Zn), manganese (Mn), selenium (Se), cobalt (Co), molybdenum (Mo), and nickel (Ni) in umbilical cord tissue are associated with risk for neural tube defects (NTDs). Umbilical cord tissues from 166 cases of NTD cases and 166 matched controls were collected and element concentrations were measured using inductively coupled plasma-mass spectrometry. Associations between ETE concentrations and the risk for NTDs were estimated using multivariate logistic regression while adjusting for potential confounders. Bayesian kernel machine regression (BKMR) was used to examine the joint effects of these ETEs. We found that median concentrations of Ni were higher but those of Mo and Co were lower in the NTD group than in the control group. Co was the only element that was associated with NTD risk after adjusting for confounders (OR 0.31, 95 % CI 0.12-0.79 for the second and OR 0.37, 95 % CI 0.15-0.91 for the top tertile relative to the lowest tertile). The association between Co and NTD risk was confirmed with the BKMR model. In addition, a joint effect of the six ETE mixture on NTD risk was observed: the risk decreased with the levels of the mixture from 25th percentile through 75th percentile. In conclusion, higher levels of Co were associated with lower risk for NTDs, and NTD risk decreased with the levels of the six ETEs as a co-exposure mixture, suggesting a protective effect. CI - Copyright (c) 2020 Elsevier Inc. All rights reserved. FAU - Liu, Mengyuan AU - Liu M AD - Institute of Reproductive and Child Health, Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Peking University, Beijing, China; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China. Electronic address: flylmy2008@126.com. FAU - Jin, Lei AU - Jin L AD - Institute of Reproductive and Child Health, Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Peking University, Beijing, China; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China. Electronic address: jinlei@bjmu.edu.cn. FAU - Yu, Jinhui AU - Yu J AD - Institute of Reproductive and Child Health, Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Peking University, Beijing, China; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China. Electronic address: yujinhui@pkuih.edu.cn. FAU - Su, Zaiming AU - Su Z AD - Institute of Reproductive and Child Health, Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Peking University, Beijing, China; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China. Electronic address: zaiming.su@qq.com. FAU - Sun, Ying AU - Sun Y AD - Institute of Reproductive and Child Health, Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Peking University, Beijing, China; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China. Electronic address: 1551179260@qq.com. FAU - Liu, Yaqiong AU - Liu Y AD - Institute of Reproductive and Child Health, Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Peking University, Beijing, China; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China. Electronic address: liuyaqiong@bjmu.edu.cn. FAU - Xie, Qing AU - Xie Q AD - Institute of Reproductive and Child Health, Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Peking University, Beijing, China; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China. Electronic address: xieqing1994@163.com. FAU - Li, Zhiwen AU - Li Z AD - Institute of Reproductive and Child Health, Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Peking University, Beijing, China; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China. Electronic address: lizw@bjmu.edu.cn. FAU - Wang, Linlin AU - Wang L AD - Institute of Reproductive and Child Health, Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Peking University, Beijing, China; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China. Electronic address: linlinwang@bjmu.edu.cn. FAU - Ren, Aiguo AU - Ren A AD - Institute of Reproductive and Child Health, Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Peking University, Beijing, China; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China; Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China. Electronic address: renag@bjmu.edu.cn. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20200921 PL - United States TA - Reprod Toxicol JT - Reproductive toxicology (Elmsford, N.Y.) JID - 8803591 RN - 0 (Metals, Heavy) RN - H6241UJ22B (Selenium) SB - IM MH - Adult MH - Case-Control Studies MH - China/epidemiology MH - Female MH - Humans MH - Metals, Heavy/*analysis MH - Neural Tube Defects/*epidemiology MH - Risk MH - Selenium/*analysis MH - Umbilical Cord/*chemistry OTO - NOTNLM OT - Cobalt OT - Essential trace element OT - Neural tube defect OT - Umbilical cord tissue EDAT- 2020/09/25 06:00 MHDA- 2021/10/21 06:00 CRDT- 2020/09/24 20:10 PHST- 2020/07/17 00:00 [received] PHST- 2020/08/28 00:00 [revised] PHST- 2020/09/16 00:00 [accepted] PHST- 2020/09/25 06:00 [pubmed] PHST- 2021/10/21 06:00 [medline] PHST- 2020/09/24 20:10 [entrez] AID - S0890-6238(20)30211-2 [pii] AID - 10.1016/j.reprotox.2020.09.007 [doi] PST - ppublish SO - Reprod Toxicol. 2020 Dec;98:149-156. doi: 10.1016/j.reprotox.2020.09.007. Epub 2020 Sep 21.