PMID- 32971476
OWN - NLM
STAT- MEDLINE
DCOM- 20201216
LR  - 20201216
IS  - 1872-8421 (Electronic)
IS  - 0165-5728 (Linking)
VI  - 349
DP  - 2020 Dec 15
TI  - Cerebrospinal fluid CD20 positive B-cell expansion in a case of anti-NMDAR 
      encephalitis.
PG  - 577365
LID - S0165-5728(20)30433-1 [pii]
LID - 10.1016/j.jneuroim.2020.577365 [doi]
AB  - Anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis is a potentially fatal 
      autoimmune encephalitis with a strong B-cell response. We measured the proportion 
      of CD20 positive and CD19 positive B-cells in the CSF from a case of severe 
      anti-NMDAR encephalitis. The proportion of CD20 positive B-cells in the CSF was 
      15.0%, higher than CD19 positive B cells (10.1%), and higher than that seen in 
      non-inflammatory neurological disorders (<1%). After the treatments of steroids, 
      intravenous immunoglobulin and rituximab to eliminate B-cells, she recovered. 
      These findings further support the use of rituximab that targets CD20 positive 
      B-cells in anti-NMDAR encephalitis.
CI  - Copyright (c) 2020. Published by Elsevier B.V.
FAU - Zheng, Yiming
AU  - Zheng Y
AD  - Neurology Department, Peking University First Hospital, China.
FAU - Luo, Jingjing
AU  - Luo J
AD  - Neurology Department, Peking University First Hospital, China.
FAU - Jin, Haiqiang
AU  - Jin H
AD  - Neurology Department, Peking University First Hospital, China.
FAU - Gao, Feng
AU  - Gao F
AD  - Neurology Department, Peking University First Hospital, China. Electronic 
      address: gaofh2011@126.com.
FAU - Hao, Hongjun
AU  - Hao H
AD  - Neurology Department, Peking University First Hospital, China. Electronic 
      address: haohj1963@126.com.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200821
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Antigens, CD20)
RN  - 0 (Autoantibodies)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Anti-N-Methyl-D-Aspartate Receptor Encephalitis/*cerebrospinal fluid/*diagnosis
MH  - Antigens, CD20/*cerebrospinal fluid
MH  - Autoantibodies/*cerebrospinal fluid
MH  - B-Lymphocytes/*metabolism
MH  - Biomarkers/cerebrospinal fluid
MH  - Female
MH  - Humans
MH  - Young Adult
OTO - NOTNLM
OT  - Anti-NMDAR encephalitis
OT  - CD19
OT  - CD20
OT  - Rituximab
EDAT- 2020/09/25 06:00
MHDA- 2020/12/17 06:00
CRDT- 2020/09/24 20:17
PHST- 2020/07/01 00:00 [received]
PHST- 2020/07/30 00:00 [revised]
PHST- 2020/08/18 00:00 [accepted]
PHST- 2020/09/25 06:00 [pubmed]
PHST- 2020/12/17 06:00 [medline]
PHST- 2020/09/24 20:17 [entrez]
AID - S0165-5728(20)30433-1 [pii]
AID - 10.1016/j.jneuroim.2020.577365 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2020 Dec 15;349:577365. doi: 10.1016/j.jneuroim.2020.577365. Epub 
      2020 Aug 21.