PMID- 32971521 OWN - NLM STAT- MEDLINE DCOM- 20220124 LR - 20220124 IS - 1423-0194 (Electronic) IS - 0028-3835 (Linking) VI - 111 IP - 7 DP - 2021 TI - Multiple Endocrine Neoplasia Type 1 and the Pancreas: Diagnosis and Treatment of Functioning and Non-Functioning Pancreatic and Duodenal Neuroendocrine Neoplasia within the MEN1 Syndrome - An International Consensus Statement. PG - 609-630 LID - 10.1159/000511791 [doi] AB - The better understanding of the biological behavior of multiple endocrine neoplasia type 1 (MEN1) organ manifestations and the increase in clinical experience warrant a revision of previously published guidelines. Duodenopancreatic neuroendocrine neoplasias (DP-NENs) are still the second most common manifestation in MEN1 and, besides NENs of the thymus, remain a leading cause of death. DP-NENs are thus of main interest in the effort to reevaluate recommendations for their diagnosis and treatment. Especially over the last 2 years, more clinical experience has documented the follow-up of treated and untreated (natural-course) DP-NENs. It was the aim of the international consortium of experts in endocrinology, genetics, radiology, surgery, gastroenterology, and oncology to systematically review the literature and to present a consensus statement based on the highest levels of evidence. Reviewing the literature published over the past decade, the focus was on the diagnosis of F- and NF-DP-NENs within the MEN1 syndrome in an effort to further standardize and improve treatment and follow-up, as well as to establish a "logbook" for the diagnosis and treatment of DP-NENs. This shall help further reduce complications and improve long-term treatment results in these rare tumors. The following international consensus statement builds upon the previously published guidelines of 2001 and 2012 and attempts to supplement the recommendations issued by various national and international societies. CI - (c) 2020 S. Karger AG, Basel. FAU - Niederle, Bruno AU - Niederle B AD - Department of Surgery, Medical University of Vienna, Vienna, Austria, bruno.niederle@meduniwien.ac.at. FAU - Selberherr, Andreas AU - Selberherr A AD - Department of Surgery, Medical University of Vienna, Vienna, Austria. FAU - Bartsch, Detlef K AU - Bartsch DK AD - Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Marburg, Germany. FAU - Brandi, Maria L AU - Brandi ML AD - Firmo Lab, Fondazione F.I.R.M.O. and University Florence, Florence, Italy. FAU - Doherty, Gerard M AU - Doherty GM AD - Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. FAU - Falconi, Massimo AU - Falconi M AD - Pancreatic Surgery, San Raffaele Scientific Institute, "Vita-Salute" University, Milan, Italy. FAU - Goudet, Pierre AU - Goudet P AD - Service de Chirurgie Viscerale et Endocrinienne, Centre Hospitalier Universitaire Francois Mitterand, Dijon, France. FAU - Halfdanarson, Thorvardur R AU - Halfdanarson TR AD - Department of Medical Oncology, Mayo Clinic Cancer Center, Rochester, Minnesota, USA. FAU - Ito, Tetsuhide AU - Ito T AD - Neuroendocrine Tumor Centre, Fukuoka Sanno Hospital and Department of Gastroenterology, Graduate School of Medical Sciences, International University of Health and Welfare, Sawara-ku, Fukuoka, Japan. FAU - Jensen, Robert T AU - Jensen RT AD - National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA. FAU - Larghi, Alberto AU - Larghi A AD - Digestive Endoscopy Unit, Fondazione Policlinico A. Gemelli IRCCS and Center for Endoscopic Research, Therapeutics and Training, Catholic University, Rome, Italy. FAU - Lee, Lingaku AU - Lee L AD - National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA. FAU - Oberg, Kjell AU - Oberg K AD - Endocrine Oncology, Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden. FAU - Pavel, Marianne AU - Pavel M AD - Endocrinology and Diabetology, Department of Medicine 1, University Clinic of Erlangen, Erlangen, Germany. FAU - Perren, Aurel AU - Perren A AD - Institute of Pathology, University of Bern, Bern, Switzerland. FAU - Sadowski, Samira M AU - Sadowski SM AD - Surgical Oncology Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. FAU - Tonelli, Francesco AU - Tonelli F AD - Department of Surgery and Translational Medicine, University of Florence, Florence, Italy. FAU - Triponez, Frederic AU - Triponez F AD - Thoracic and Endocrine Surgery, University Hospital of Geneva, Geneva, Switzerland. FAU - Valk, Gerlof D AU - Valk GD AD - Department of Endocrine Oncology, University Medical Center Utrecht, Utrecht, The Netherlands. FAU - O'Toole, Dermot AU - O'Toole D AD - Department of Clinical Medicine, St. James's Hospital and St Vincent's University Hospital and Trinity College, Dublin, Ireland. FAU - Scott-Coombes, David AU - Scott-Coombes D AD - Department of Endocrine Surgery, University Hospital of Wales, Cardiff, United Kingdom. FAU - Thakker, Rajesh V AU - Thakker RV AD - Academic Endocrine Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, University of Oxford, Oxford, United Kingdom. FAU - Thompson, Geoffrey B AU - Thompson GB AD - Section of Endocrine Surgery, Department of Gastroenterologic and General Surgery, Mayo Clinic, Rochester, Minnesota, USA. FAU - Treglia, Giorgio AU - Treglia G AD - Imaging Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, Switzerland. FAU - Wiedenmann, Bertram AU - Wiedenmann B AD - Department of Gastroenterology and Hepatology, Campus Virchow-Klinikum and Campus Charite Mitte, Charite - Universitatsmedizin Berlin, Berlin, Germany. LA - eng PT - Journal Article PT - Review DEP - 20200924 PL - Switzerland TA - Neuroendocrinology JT - Neuroendocrinology JID - 0035665 SB - IM MH - *Consensus MH - *Duodenal Neoplasms/diagnosis/therapy MH - Humans MH - *Multiple Endocrine Neoplasia Type 1/diagnosis/therapy MH - *Pancreatic Neoplasms/diagnosis/therapy OTO - NOTNLM OT - Consensus statement OT - Diagnosis OT - Multiple endocrine neoplasia type 1 OT - Neuroendocrine pancreatic tumors OT - Treatment EDAT- 2020/09/25 06:00 MHDA- 2022/01/27 06:00 CRDT- 2020/09/24 20:20 PHST- 2020/06/25 00:00 [received] PHST- 2020/09/18 00:00 [accepted] PHST- 2020/09/25 06:00 [pubmed] PHST- 2022/01/27 06:00 [medline] PHST- 2020/09/24 20:20 [entrez] AID - 000511791 [pii] AID - 10.1159/000511791 [doi] PST - ppublish SO - Neuroendocrinology. 2021;111(7):609-630. doi: 10.1159/000511791. Epub 2020 Sep 24.