PMID- 32971523
OWN - NLM
STAT- MEDLINE
DCOM- 20210812
LR  - 20221207
IS  - 1421-9697 (Electronic)
IS  - 0250-6807 (Linking)
VI  - 76
IP  - 3
DP  - 2020
TI  - Evaluation of the Associations of GC and CYP2R1 Genes and Gene-Obesity 
      Interactions with Type 2 Diabetes Risk in a Chinese Rural Population.
PG  - 175-182
LID - 10.1159/000508024 [doi]
AB  - INTRODUCTION: Group-specific component (GC) and cytochrome P450 family 2 
      subfamily R member 1 (CYP2R1) gene polymorphisms and obesity have been associated 
      with an increased risk for development of type 2 diabetes mellitus (T2DM) in 
      Asian populations. OBJECTIVE: This study assessed the associations of 
      interactions between GC gene variants and CYP2R1 gene variants and between genes 
      and obesity with T2DM risk. METHODS: A study that included 2,271 subjects was 
      performed. Eight single nucleotide polymorphisms in the GC and CYP2R1 genes were 
      genotyped. Interaction analysis was performed using rs7041 in the GC gene and 
      rs1993116 in the CYP2R1 gene. The effects of multiplicative and additive 
      gene-gene and gene-environment interactions on T2DM risk were assessed. RESULTS: 
      The T2DM risk was significantly associated with being overweight/obese, abdominal 
      obesity, rs7041, and rs1993116. A significant additive interaction between 
      rs1993116 and rs7041 was associated with T2DM. In addition, there was a 
      significant multiplicative interaction between rs7041 and body mass index (BMI) 
      associated with elevated blood glucose levels, and at a higher BMI (>28.47), the 
      G allele carrier showed a stronger effect than the TT genotype. CONCLUSIONS: The 
      interactions between GC rs7041-CYP2R1 rs1993116 and GC rs7041-BMI may explain the 
      mechanisms by which these factors increase the risk of T2DM development.
CI  - (c) 2020 S. Karger AG, Basel.
FAU - Zhao, Yanting
AU  - Zhao Y
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Tongji 
      Medical College, Huazhong University of Science and Technology, Wuhan, China.
FAU - Wang, Gaoshuai
AU  - Wang G
AD  - Department of Hospital Infection Control, The Second Affiliated Hospital of 
      Zhengzhou University, Zhengzhou, China.
FAU - Li, Yuqian
AU  - Li Y
AD  - Department of Clinical Pharmacology, School of Pharmaceutical Science, Zhengzhou 
      University, Zhengzhou, China.
FAU - Liu, Xiaotian
AU  - Liu X
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, China.
FAU - Liu, Li
AU  - Liu L
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Tongji 
      Medical College, Huazhong University of Science and Technology, Wuhan, China.
FAU - Yang, Kaili
AU  - Yang K
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, China.
FAU - Wang, Chongjian
AU  - Wang C
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, China.
FAU - Wei, Sheng
AU  - Wei S
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Tongji 
      Medical College, Huazhong University of Science and Technology, Wuhan, China, 
      ws2008cn@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200924
PL  - Switzerland
TA  - Ann Nutr Metab
JT  - Annals of nutrition & metabolism
JID - 8105511
RN  - 0 (Vitamin D-Binding Protein)
RN  - EC 1.14.14.1 (Cytochrome P450 Family 2)
RN  - EC 1.14.14.24 (CYP2R1 protein, human)
RN  - EC 1.14.15.15 (Cholestanetriol 26-Monooxygenase)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Asian People/genetics
MH  - Body Mass Index
MH  - China
MH  - Cholestanetriol 26-Monooxygenase/*genetics
MH  - Cross-Sectional Studies
MH  - Cytochrome P450 Family 2/*genetics
MH  - Diabetes Mellitus, Type 2/ethnology/*genetics
MH  - Epistasis, Genetic
MH  - Female
MH  - Gene-Environment Interaction
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Obesity/ethnology/*genetics
MH  - Pedigree
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Risk Factors
MH  - Rural Population/statistics & numerical data
MH  - Vitamin D-Binding Protein/*genetics
MH  - Young Adult
OTO - NOTNLM
OT  - Body mass index
OT  - CYP2R1 gene
OT  - GC gene
OT  - Interaction
OT  - Type 2 diabetes mellitus
OT  - Waist circumference
EDAT- 2020/09/25 06:00
MHDA- 2021/08/13 06:00
CRDT- 2020/09/24 20:20
PHST- 2019/09/24 00:00 [received]
PHST- 2020/04/17 00:00 [accepted]
PHST- 2020/09/25 06:00 [pubmed]
PHST- 2021/08/13 06:00 [medline]
PHST- 2020/09/24 20:20 [entrez]
AID - 000508024 [pii]
AID - 10.1159/000508024 [doi]
PST - ppublish
SO  - Ann Nutr Metab. 2020;76(3):175-182. doi: 10.1159/000508024. Epub 2020 Sep 24.