PMID- 32972337
OWN - NLM
STAT- MEDLINE
DCOM- 20211115
LR  - 20211115
IS  - 1875-5402 (Electronic)
IS  - 1386-2073 (Linking)
VI  - 24
IP  - 5
DP  - 2021
TI  - Activated Carbon/MoO(3): Efficient Catalyst for Green Synthesis of 
      Chromeno[d]pyrimidinediones and Xanthenones.
PG  - 683-694
LID - 10.2174/1386207323666200924111602 [doi]
AB  - BACKGROUND: Nanoscale metal oxide catalysts have been extensively employed in 
      organic reactions because they have been found to influence the chemical and 
      physical properties of bulk material. The chromene (benzopyran) nucleus 
      constitutes the core structure in a major class of many biologically active 
      compounds, and interest in their chemistry consequently continues because of 
      their numerous biological activities. The xanthene (dibenzopyran) derivatives are 
      classified as highly significant compounds which display a number of various 
      bioactive properties. Pyrimidinones have also gained interest due to their 
      remarkable biological utilization, such as antiviral, antibacterial, 
      antihypertensive, antitumor, and calcium blockers effects. OBJECTIVE: The aim of 
      this work presented herein was to prepare activated carbon/MoO3 nanocomposite and 
      explore its role as a green and recyclable catalyst for the synthesis of 
      chromeno[d]pyrimidinediones and xanthenones under ethanol-drop grinding at room 
      temperature. METHODS: The activated carbon/MoO3 nanocomposite was prepared 
      successfully via a simple route in which the carbonization of gums as new natural 
      precursors was used for the synthesis of activated carbon. This nanocomposite was 
      then effectively used in a reaction of 3,4-methylenedioxyphenol, aromatic 
      aldehydes, and active methylene compounds, including 1,3-dimethylbarbituric acid 
      and dimedone, to synthesize a series of chromeno[d]pyrimidinediones and 
      xanthenones in high yields. The synthesized catalyst was characterized by Fourier 
      transform infrared spectroscopy (FT-IR), Powder x-ray diffractometry (XRD), 
      Scanning electron microscope (SEM), Raman spectroscopy, and also by TGA analysis. 
      Confirmation of the structures of compounds 5(a-g) and 6(a-g) were also 
      established with IR, 1H NMR, and 13C NMR spectroscopic data and also by elemental 
      analyses. RESULTS: A number of 
      6,8-dimethyl-10-phenyl-6,10-dihydro-7H-[1,3]dioxolo[4 ,5 :6,7]chromeno[2,3- 
      d]pyrimidine-7,9(8H)-diones and 
      7,7-dimethyl-10-(4-methylphenyl)-6,7,8,10-tetrahydro-9H-[1,3]dioxolo[ 
      4,5-b]xanthen-9-ones were effectively synthesized using activated carbon/MoO3 
      nanocomposite (0.05 gr) as a catalyst under ethanol-drop grinding at room 
      temperature. The desired products were obtained in high yields (93-97%) within 
      short reaction times (15-20 min). CONCLUSION: This paper investigates the 
      catalytic potential of the synthesized activated carbon/MoO3 nanocomposite for 
      the preparation of chromeno[d]pyrimidinediones and xanthenones under the 
      ethanol-drop grinding procedure. The mildness of the reaction conditions, high 
      yields of products, short reaction times, experimental simplicity, and avoiding 
      the use of harmful solvents or reagents makes this procedure preferable for the 
      synthesis of these compounds.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.net.
FAU - Mehr, Niloofar Sabet
AU  - Mehr NS
AD  - Department of Chemistry, East Tehran Branch, Islamic Azad University, P.O. Box 
      18735-138, Tehran, Iran.
FAU - Abdolmohammadi, Shahrzad
AU  - Abdolmohammadi S
AD  - Department of Chemistry, East Tehran Branch, Islamic Azad University, P.O. Box 
      18735-138, Tehran, Iran.
FAU - Afsharpour, Maryam
AU  - Afsharpour M
AD  - Department of Inorganic Chemistry, Chemistry & Chemical Engineering Research 
      Center of Iran, PO Box 14335-186, Tehran, Iran.
LA  - eng
PT  - Journal Article
PL  - United Arab Emirates
TA  - Comb Chem High Throughput Screen
JT  - Combinatorial chemistry & high throughput screening
JID - 9810948
RN  - 0 (Oxides)
RN  - 0 (Pyrimidinones)
RN  - 0 (Xanthenes)
RN  - 22FQ3F03YS (molybdenum trioxide)
RN  - 7440-44-0 (Carbon)
RN  - 81AH48963U (Molybdenum)
SB  - IM
MH  - Carbon/*chemistry
MH  - Catalysis
MH  - Molecular Structure
MH  - Molybdenum/*chemistry
MH  - Oxides/*chemistry
MH  - Pyrimidinones/*chemical synthesis/chemistry
MH  - Xanthenes/*chemical synthesis/chemistry
OTO - NOTNLM
OT  - Chromeno[d]pyrimidinediones
OT  - MCRs
OT  - activated carbon/MoO3 nanocomposite
OT  - ethanol-drop grinding
OT  - recyclability of the catalyst
OT  - xanthenones
EDAT- 2020/09/26 06:00
MHDA- 2021/11/16 06:00
CRDT- 2020/09/25 05:31
PHST- 2020/04/02 00:00 [received]
PHST- 2020/07/22 00:00 [revised]
PHST- 2020/08/11 00:00 [accepted]
PHST- 2020/09/26 06:00 [pubmed]
PHST- 2021/11/16 06:00 [medline]
PHST- 2020/09/25 05:31 [entrez]
AID - CCHTS-EPUB-110193 [pii]
AID - 10.2174/1386207323666200924111602 [doi]
PST - ppublish
SO  - Comb Chem High Throughput Screen. 2021;24(5):683-694. doi: 
      10.2174/1386207323666200924111602.