PMID- 32973422
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 1662-4548 (Print)
IS  - 1662-453X (Electronic)
IS  - 1662-453X (Linking)
VI  - 14
DP  - 2020
TI  - Delayed Functional Networks Development and Altered Fast Oscillation Dynamics in 
      a Rat Model of Cortical Malformation.
PG  - 711
LID - 10.3389/fnins.2020.00711 [doi]
LID - 711
AB  - Malformations of cortical development (MCD) is associated with a wide range of 
      developmental delay and drug resistant epilepsy in children. By using 
      resting-state functional magnetic resonance imaging (RS-fMRI) and event-related 
      spectral perturbation (ERSP) of cortical electroencephalography (EEG) data, we 
      tried to investigate the neural changes of spatiotemporal functional connectivity 
      (FC) and fast oscillation (FO) dynamics in a rat model of methylazoxymethanol 
      (MAM)-induced MCD. A total of 28 infant rats with prenatal exposure to MAM and 
      those of age matched 28 controls with prenatal saline exposure were used. RS-fMRI 
      were acquired at postnatal day 15 (P15) and 29 (P29), and correlation coefficient 
      analysis of eleven region of interests (ROI) was done to find the differences of 
      functional networks between four groups. Two hour-cortical EEGs were also 
      recorded at P15 and P29 and the ERSP of gamma (30-80 Hz) and ripples (80-200 Hz) 
      were analyzed. The rats with MCD showed significantly delayed development of 
      superior colliculus-brainstem network compared to control rats at P15. In 
      contrast to marked maturation of default mode network (DMN) in controls from P15 
      to P29, there was no clear development in MCD rats. The MCD rats showed 
      significantly higher cortical gamma and ripples-ERSP at P15 and lower cortical 
      ripples-ERSP at P29 than those of control rats. This study demonstrated delayed 
      development of FC and altered cortical FO dynamics in rats with malformed brain. 
      The results should be further investigated in terms of the epileptogenesis and 
      cognitive dysfunction in patients with MCD.
CI  - Copyright (c) 2020 Kim, Yum, Jo, Lee, Kim, Shim and Ko.
FAU - Kim, Min-Jee
AU  - Kim MJ
AD  - Department of Pediatrics, Asan Medical Center Children's Hospital, University of 
      Ulsan College of Medicine, Seoul, South Korea.
FAU - Yum, Mi-Sun
AU  - Yum MS
AD  - Department of Pediatrics, Asan Medical Center Children's Hospital, University of 
      Ulsan College of Medicine, Seoul, South Korea.
FAU - Jo, Youngheun
AU  - Jo Y
AD  - Department of Radiology, Asan Medical Center, University of Ulsan College of 
      Medicine, Seoul, South Korea.
FAU - Lee, Minyoung
AU  - Lee M
AD  - Department of Pediatrics, Asan Medical Center Children's Hospital, University of 
      Ulsan College of Medicine, Seoul, South Korea.
FAU - Kim, Eun-Jin
AU  - Kim EJ
AD  - Department of Pediatrics, Asan Medical Center Children's Hospital, University of 
      Ulsan College of Medicine, Seoul, South Korea.
FAU - Shim, Woo-Hyun
AU  - Shim WH
AD  - Department of Radiology, Asan Medical Center, University of Ulsan College of 
      Medicine, Seoul, South Korea.
FAU - Ko, Tae-Sung
AU  - Ko TS
AD  - Department of Pediatrics, Asan Medical Center Children's Hospital, University of 
      Ulsan College of Medicine, Seoul, South Korea.
LA  - eng
PT  - Journal Article
DEP - 20200818
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC7461924
OTO - NOTNLM
OT  - event-related spectral perturbation
OT  - functional connectivity
OT  - gamma
OT  - malformations of cortical development
OT  - resting state functional magnetic resonance images
OT  - ripples
EDAT- 2020/09/26 06:00
MHDA- 2020/09/26 06:01
PMCR- 2020/01/01
CRDT- 2020/09/25 06:00
PHST- 2020/01/16 00:00 [received]
PHST- 2020/06/12 00:00 [accepted]
PHST- 2020/09/25 06:00 [entrez]
PHST- 2020/09/26 06:00 [pubmed]
PHST- 2020/09/26 06:01 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.3389/fnins.2020.00711 [doi]
PST - epublish
SO  - Front Neurosci. 2020 Aug 18;14:711. doi: 10.3389/fnins.2020.00711. eCollection 
      2020.