PMID- 32973673
OWN - NLM
STAT- MEDLINE
DCOM- 20210603
LR  - 20210603
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 11
DP  - 2020
TI  - Corticotropin-Releasing Factor: An Ancient Peptide Family Related to the Secretin 
      Peptide Superfamily.
PG  - 529
LID - 10.3389/fendo.2020.00529 [doi]
LID - 529
AB  - Corticotropin-releasing factor (CRF) is the hypothalamic releasing peptide that 
      regulates the hypothalamic-pituitary-adrenal/inter-renal (HPA/I) axis in 
      vertebrates. Over the last 25 years, there has been considerable discussion on 
      its paralogs genes, urotensin-I/urocortin-1, and urocortins-2 and-3 and their 
      subsequent role in the vertebrate stress response. Phylogenetically, the CRF 
      family of peptides also belong to the diverse assemblage of Secretin- and 
      Calcitonin-based peptides as evidenced by comparative-based studies of both their 
      ligand and G-protein-coupled receptor (GPCR) structures. Despite this, the common 
      origin of this large assemblage of peptides has not been ascertained. An unusual 
      peptide, teneurin-C-terminal associated peptide (TCAP), reported in 2004, 
      comprises the distal extracellular tip of the teneurin transmembrane proteins. 
      Further studies indicated that this teneurin region binds to the latrophilin 
      family of GPCRs. Initially thought to be a member of the Secretin GPCR family, 
      evidence indicates that the latrophilins are a member of the Adhesion family of 
      GPCRs and are related to the common ancestor of both Adhesion and Secretin GPCR 
      families. In this study, we posit that TCAP may be a distantly related ancestor 
      of the CRF-Calcitonin-Secretin peptide family and evolved near the base of 
      metazoan phylogeny.
CI  - Copyright (c) 2020 Michalec, Chang, Lovejoy and Lovejoy.
FAU - Michalec, Ola M
AU  - Michalec OM
AD  - Department of Cell and Systems Biology, University of Toronto - St. George 
      Campus, Toronto, ON, Canada.
FAU - Chang, Belinda S W
AU  - Chang BSW
AD  - Department of Cell and Systems Biology, University of Toronto - St. George 
      Campus, Toronto, ON, Canada.
FAU - Lovejoy, Nathan R
AU  - Lovejoy NR
AD  - Department of Biological Sciences, University of Toronto Scarborough, Toronto, 
      ON, Canada.
FAU - Lovejoy, David A
AU  - Lovejoy DA
AD  - Department of Cell and Systems Biology, University of Toronto - St. George 
      Campus, Toronto, ON, Canada.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200827
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
RN  - 0 (secretin releasing peptide)
RN  - 1393-25-5 (Secretin)
RN  - 9015-71-8 (Corticotropin-Releasing Hormone)
SB  - IM
MH  - Amino Acid Sequence
MH  - Corticotropin-Releasing Hormone/genetics/*metabolism
MH  - *Databases, Factual
MH  - *Evolution, Molecular
MH  - Humans
MH  - *Multigene Family
MH  - *Phylogeny
MH  - Secretin/genetics/*metabolism
MH  - Sequence Homology
PMC - PMC7481443
OTO - NOTNLM
OT  - TCAP
OT  - adhesion GPCRs
OT  - evolution
OT  - metabolism
OT  - secretin superfamily
OT  - teneurin
EDAT- 2020/09/26 06:00
MHDA- 2021/06/04 06:00
PMCR- 2020/01/01
CRDT- 2020/09/25 06:01
PHST- 2020/04/20 00:00 [received]
PHST- 2020/06/29 00:00 [accepted]
PHST- 2020/09/25 06:01 [entrez]
PHST- 2020/09/26 06:00 [pubmed]
PHST- 2021/06/04 06:00 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2020.00529 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2020 Aug 27;11:529. doi: 10.3389/fendo.2020.00529. 
      eCollection 2020.