PMID- 32973741
OWN - NLM
STAT- MEDLINE
DCOM- 20210412
LR  - 20210412
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 11
DP  - 2020
TI  - Hidradenitis Suppurativa and 1-Carbon Metabolism: Role of Gut Microbiome, Matrix 
      Metalloproteinases, and Hyperhomocysteinemia.
PG  - 1730
LID - 10.3389/fimmu.2020.01730 [doi]
LID - 1730
AB  - Hidradenitis suppurativa (HS) is a chronic, inflammatory skin condition 
      characterized by painful nodules which suppurate and later develop into scar 
      tissues followed by the development of hypodermal tracts. Although the mechanisms 
      behind HS are not fully understood, it is known that dietary factors play 
      important roles in flare frequency and severity. We hypothesize that the high fat 
      diet (HFD) causes dysbiosis, systemic inflammation, and hyperhomocysteinemia 
      (HHcy) in susceptible individuals, which subsequently elevate inflammatory 
      cytokines such as IL-1beta, IL-6, IL-17, and tumor necrosis factor alpha (TNF-alpha). 
      This increase in dysbiosis-led inflammation coupled with a dysregulation of the 
      1-carbon metabolism results in an increase in matrix metalloproteinases MMP-2, 
      MMP-8, and MMP-9 along with tissue matrix remodeling in the development and 
      maintenance of the lesions and tracts. This manuscript weaves together the 
      potential roles played by the gut microbiome, HHcy, MMPs, and the 1-carbon 
      metabolism toward HS disease causation in susceptible individuals.
CI  - Copyright (c) 2020 Molnar, Mallonee, Stanisic, Homme, George, Singh and Tyagi.
FAU - Molnar, Jack
AU  - Molnar J
AD  - Department of Physiology, University of Louisville School of Medicine, 
      Louisville, KY, United States.
FAU - Mallonee, Carissa Jo
AU  - Mallonee CJ
AD  - Department of Physiology, University of Louisville School of Medicine, 
      Louisville, KY, United States.
FAU - Stanisic, Dragana
AU  - Stanisic D
AD  - Department of Dentistry, Faculty of Medical Sciences, University of Kragujevac, 
      Kragujevac, Serbia.
FAU - Homme, Rubens P
AU  - Homme RP
AD  - Department of Physiology, University of Louisville School of Medicine, 
      Louisville, KY, United States.
FAU - George, Akash K
AU  - George AK
AD  - Department of Physiology, University of Louisville School of Medicine, 
      Louisville, KY, United States.
FAU - Singh, Mahavir
AU  - Singh M
AD  - Department of Physiology, University of Louisville School of Medicine, 
      Louisville, KY, United States.
FAU - Tyagi, Suresh C
AU  - Tyagi SC
AD  - Department of Physiology, University of Louisville School of Medicine, 
      Louisville, KY, United States.
LA  - eng
GR  - R01 AR071789/AR/NIAMS NIH HHS/United States
GR  - R01 DK116591/DK/NIDDK NIH HHS/United States
GR  - R01 HL074185/HL/NHLBI NIH HHS/United States
GR  - R01 HL139047/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20200819
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
RN  - 0 (Biomarkers)
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - EC 3.4.24.- (Matrix Metalloproteinases)
SB  - IM
MH  - Animals
MH  - Bacteria/*metabolism
MH  - Biomarkers/blood
MH  - Diet, High-Fat/*adverse effects
MH  - Dysbiosis
MH  - *Gastrointestinal Microbiome
MH  - Hidradenitis Suppurativa/enzymology/*etiology/microbiology/pathology
MH  - Homocysteine/*blood
MH  - Humans
MH  - Hyperhomocysteinemia/blood/*complications
MH  - Matrix Metalloproteinases/*metabolism
MH  - Risk Assessment
MH  - Risk Factors
MH  - Skin/*enzymology/pathology
PMC - PMC7466742
OTO - NOTNLM
OT  - acne
OT  - dysbiosis
OT  - extracellular matrix
OT  - homocysteine
OT  - tissue remodeling
EDAT- 2020/09/26 06:00
MHDA- 2021/04/13 06:00
PMCR- 2020/01/01
CRDT- 2020/09/25 06:01
PHST- 2020/03/26 00:00 [received]
PHST- 2020/06/29 00:00 [accepted]
PHST- 2020/09/25 06:01 [entrez]
PHST- 2020/09/26 06:00 [pubmed]
PHST- 2021/04/13 06:00 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2020.01730 [doi]
PST - epublish
SO  - Front Immunol. 2020 Aug 19;11:1730. doi: 10.3389/fimmu.2020.01730. eCollection 
      2020.