PMID- 32974668
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20210804
IS  - 1522-9645 (Electronic)
IS  - 0195-668X (Linking)
VI  - 41
IP  - 45
DP  - 2020 Dec 1
TI  - Isolated tricuspid valve surgery: impact of aetiology and clinical presentation 
      on outcomes.
PG  - 4304-4317
LID - 10.1093/eurheartj/ehaa643 [doi]
AB  - AIMS: The aim of this study was to identify determinants of in-hospital and 
      mid-term outcomes after isolated tricuspid valve surgery (ITVS) and more 
      specifically the impact of tricuspid regurgitation (TR) mechanism and clinical 
      presentation. METHODS AND RESULTS: Among 5661 consecutive adult patients who 
      underwent a tricuspid valve (TV) surgery at 12 French tertiary centres in 
      2007-2017 collected from a mandatory administrative database, we identified 466 
      patients (8% of all tricuspid surgeries) who underwent an ITVS. Most patients 
      presented with advanced disease [47% in New York Heart Association (NYHA) III/IV, 
      57% with right-sided heart failure (HF) signs]. Tricuspid regurgitation was 
      functional in 49% (22% with prior left-sided heart valve surgery and 27% 
      isolated) and organic in 51% (infective endocarditis in 31% and other causes in 
      20%). In-hospital mortality and major complications rates were 10% and 31%, 
      respectively. Rates of survival and survival free of HF readmission were 75% and 
      62% at 5 years. Patients with functional TR incurred a worse in-hospital 
      mortality than those with organic TR (14% vs. 6%, P = 0.004), but presentation 
      was more severe. Independent determinants of outcomes were NYHA Class III/IV [odd 
      ratios (OR) = 2.7 (1.2-6.1), P = 0.01], moderate/severe right ventricular 
      dysfunction [OR = 2.6 (1.2-5.8), P = 0.02], lower prothrombin time [OR = 0.98 
      (0.96-0.99), P = 0.008], and with borderline statistical significance, 
      right-sided HF signs [OR = 2.4 (0.9-6.5), P = 0.06] while TR mechanism was not 
      [OR = 0.7 (0.3-1.8), P = 0.88]. CONCLUSION: Isolated TV surgery was associated 
      with high mortality and morbidity, both in hospital and during follow-up, 
      predicted by the severity of the presentation but not by TR mechanism. Our 
      results suggest that TV intervention should be performed earlier in the course of 
      the disease.
CI  - Published on behalf of the European Society of Cardiology. All rights reserved. (c) 
      The Author(s) 2020. For permissions, please email: journals.permissions@oup.com.
FAU - Dreyfus, Julien
AU  - Dreyfus J
AD  - Cardiology Department, Centre Cardiologique du Nord, 32-36 rue des moulins 
      gemeaux, Saint-Denis 93200, France.
FAU - Flagiello, Michele
AU  - Flagiello M
AD  - Department of Cardiovascular Surgery and Transplantation, Louis Pradel 
      Cardiovascular Hospital, Claude Bernard University, 59 Boulevard Pinel, 69500 
      Bron, France.
FAU - Bazire, Baptiste
AU  - Bazire B
AD  - Department of Cardiology, Bichat Claude Bernard Hospital, 46 Rue Henri Huchard, 
      75018 Paris, France.
FAU - Eggenspieler, Florian
AU  - Eggenspieler F
AD  - Department of Cardiology, University Hospital of Nancy-Brabois, 29 Avenue du 
      Marechal de Lattre de Tassigny, 54035 Nancy, France.
FAU - Viau, Florence
AU  - Viau F
AD  - Cardiology Department, APHM, La Timone Hospital, 278 Rue Saint-Pierre, 13005 
      Marseille, France.
FAU - Riant, Elisabeth
AU  - Riant E
AD  - Cardiology Department, Expert Valve Center, Henri Mondor Hospital, 51 Avenue du 
      Marechal de Lattre de Tassigny, 94010 Creteil, France.
FAU - Mbaki, Yannick
AU  - Mbaki Y
AD  - Cardiology Department, CHU de RENNES, LTSI UMR1099, INSERM, Universite de 
      Rennes-1, 2 Rue Henri le Guilloux, 35000 Rennes, France.
FAU - Bohbot, Yohann
AU  - Bohbot Y
AD  - Department of Cardiology, Amiens University Hospital, 1 Rue du Professeur 
      Christian Cabrol, 80054 Amiens, France.
AD  - UR UPJV 7517, Jules Verne University of Picardie, 51 Boulevard de Chateaudun, 
      80000 Amiens, France.
FAU - Eyharts, Damien
AU  - Eyharts D
AD  - Department of Cardiology, Rangueil University Hospital, 9 Place Lange, 31300 
      Toulouse, France.
FAU - Senage, Thomas
AU  - Senage T
AD  - Department of Cardiac Surgery, INSERM 1246, Universite de Nantes, CHU de Nantes, 
      8 Quai Moncousu, 44007 Nantes, France.
FAU - Dubrulle, Henri
AU  - Dubrulle H
AD  - Department of Clinical Physiology and Echocardiography - Heart Valve Clinic, CHU 
      Lille, 2 Avenue Oscar Lambret, 59000 Lille, France.
FAU - Nicol, Martin
AU  - Nicol M
AD  - Cardiology Department, Centre Cardiologique du Nord, 32-36 rue des moulins 
      gemeaux, Saint-Denis 93200, France.
FAU - Doguet, Fabien
AU  - Doguet F
AD  - Service de chirurgie cardiovasculaire et thoracique, CHU Charles Nicolle, 37 
      Boulevard Gambetta, 76000 Rouen, France.
AD  - Normandie Univ, Unirouen, INSERM U1096, Rouen 76000, France.
FAU - Nguyen, Virginia
AU  - Nguyen V
AD  - Cardiology Department, Centre Cardiologique du Nord, 32-36 rue des moulins 
      gemeaux, Saint-Denis 93200, France.
FAU - Coisne, Augustin
AU  - Coisne A
AD  - Department of Clinical Physiology and Echocardiography - Heart Valve Clinic, CHU 
      Lille, 2 Avenue Oscar Lambret, 59000 Lille, France.
AD  - Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011 - EGID, Lille 
      F-59000, France.
FAU - Le Tourneau, Thierry
AU  - Le Tourneau T
AD  - Universite de Nantes, CHU de Nantes, CNRS, INSERM, l'institut du thorax, Nantes 
      F-44000, France.
FAU - Lavie-Badie, Yoan
AU  - Lavie-Badie Y
AD  - Department of Cardiology, Rangueil University Hospital, 9 Place Lange, 31300 
      Toulouse, France.
FAU - Tribouilloy, Christophe
AU  - Tribouilloy C
AD  - Department of Cardiology, Amiens University Hospital, 1 Rue du Professeur 
      Christian Cabrol, 80054 Amiens, France.
AD  - UR UPJV 7517, Jules Verne University of Picardie, 51 Boulevard de Chateaudun, 
      80000 Amiens, France.
FAU - Donal, Erwan
AU  - Donal E
AD  - Cardiology Department, CHU de RENNES, LTSI UMR1099, INSERM, Universite de 
      Rennes-1, 2 Rue Henri le Guilloux, 35000 Rennes, France.
FAU - Tomasi, Jacques
AU  - Tomasi J
AD  - Department of Cardiac Surgery, CHU de RENNES, Universite de Rennes-1, 2 Rue Henri 
      le Guilloux, 35000 Rennes, France.
FAU - Habib, Gilbert
AU  - Habib G
AD  - Cardiology Department, APHM, La Timone Hospital, 278 Rue Saint-Pierre, 13005 
      Marseille, France.
AD  - Aix Marseille Univ, IRD, APHM, MEPHI, IHU-Mediterranee Infection, 19-21 Boulevard 
      Jean Moulin, 13005 Marseille, France.
FAU - Selton-Suty, Christine
AU  - Selton-Suty C
AD  - Department of Cardiology, University Hospital of Nancy-Brabois, 29 Avenue du 
      Marechal de Lattre de Tassigny, 54035 Nancy, France.
FAU - Raffoul, Richard
AU  - Raffoul R
AD  - Department of Cardiac Surgery, AP-HP, Bichat Hospital, 46 Rue Henri Huchard, 
      75018 Paris, France.
FAU - Iung, Bernard
AU  - Iung B
AD  - Cardiology Department, AP-HP, DHU Fire, Bichat Hospital, Universite de Paris, 46 
      Rue Henri Huchard, 75018 Paris, France.
FAU - Obadia, Jean-Francois
AU  - Obadia JF
AD  - Department of Cardiovascular Surgery and Transplantation, Louis Pradel 
      Cardiovascular Hospital, Claude Bernard University, 59 Boulevard Pinel, 69500 
      Bron, France.
FAU - Messika-Zeitoun, David
AU  - Messika-Zeitoun D
AD  - Department of Cardiology, University of Ottawa Heart Institute, 40 ruskin street, 
      Ottawa, Ontario, Canada.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Eur Heart J
JT  - European heart journal
JID - 8006263
SB  - IM
CIN - Eur Heart J. 2020 Dec 1;41(45):4318-4320. PMID: 32984873
CIN - Eur Heart J. 2021 May 14;42(19):1926. PMID: 33313740
MH  - Adult
MH  - *Heart Valve Prosthesis Implantation/adverse effects
MH  - Humans
MH  - Retrospective Studies
MH  - Treatment Outcome
MH  - Tricuspid Valve/surgery
MH  - *Tricuspid Valve Insufficiency/epidemiology/surgery
MH  - *Ventricular Dysfunction, Right
OTO - NOTNLM
OT  - Outcome
OT  - Surgery
OT  - Tricuspid regurgitation
EDAT- 2020/09/26 06:00
MHDA- 2021/05/15 06:00
CRDT- 2020/09/25 06:05
PHST- 2020/04/18 00:00 [received]
PHST- 2020/06/21 00:00 [revised]
PHST- 2020/07/23 00:00 [accepted]
PHST- 2020/09/26 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
PHST- 2020/09/25 06:05 [entrez]
AID - 5911419 [pii]
AID - 10.1093/eurheartj/ehaa643 [doi]
PST - ppublish
SO  - Eur Heart J. 2020 Dec 1;41(45):4304-4317. doi: 10.1093/eurheartj/ehaa643.