PMID- 32975739
OWN - NLM
STAT- MEDLINE
DCOM- 20210622
LR  - 20210723
IS  - 1559-0720 (Electronic)
IS  - 0163-4984 (Linking)
VI  - 199
IP  - 7
DP  - 2021 Jul
TI  - Changes in Bone Turnover, Inflammatory, Oxidative Stress, and Metabolic Markers 
      in Women Consuming Iron plus Vitamin D Supplements: a Randomized Clinical Trial.
PG  - 2590-2601
LID - 10.1007/s12011-020-02400-8 [doi]
AB  - We aimed to investigate whether combination of vitamin D and iron 
      supplementation, comparing vitamin D alone, could modify bone turnover, 
      inflammatory, oxidative stress, and metabolic markers. Eighty-seven women with 
      hemoglobin (Hb) </= 12.7 g/dL and 25OHD </= 29 ng/mL vitamin D 
      deficiency/insufficiency aged 18-45 years were randomly assigned into two groups: 
      (1) receiving either 1000 IU/day vitamin D3 plus 27 mg/day iron (D-Fe); (2) 
      vitamin D3 plus placebo supplements (D-P), for 12 weeks. In D-Fe group, 
      significant decrease in red blood cells (RBC) (P = 0.001) and hematocrit (Hct) (P 
      = 0.004) and increases in mean corpuscular hemoglobin concentration (MCHC) (P = 
      0.001), 25OHD (P < 0.001), osteocalcin (P < 0.001), high-density cholesterol 
      (HDL) (P = 0.041), and fasting blood sugar (FBS) (P < 0.001) were observed. D-P 
      group showed significant decrease in RBC (P < 0.001), Hb (P < 0.001), Hct (P < 
      0.001), mean corpuscular volume (MCV) (P = 0.004), mean corpuscular hemoglobin 
      (MCH) (P < 0.001), MCHC (P = 0.005), serum ferritin (P < 0.001), and low-density 
      cholesterol (LDL) (P = 0.016) and increases of 25OHD (P < 0.001), osteocalcin (P 
      < 0.001), C-terminal telopeptide (CTX) (P = 0.025), triglyceride (TG) (P = 
      0.004), FBS (P < 0.001), and interleukin-6 (IL-6) (P = 0.001) at week 12. After 
      the intervention, the D-P group had between-group increases in mean change in the 
      osteocalcin (P = 0.007) and IL-6 (P = 0.033), and decreases in the RBC (P < 
      0.001), Hb (P < 0.001), Hct (P < 0.001), and MCV (P = 0.001), compared with the 
      D-Fe group. There were significant between-group changes in MCH (P < 0.001), MCHC 
      (P < 0.001), ferritin (P < 0.001), and serum iron (P = 0.018). Iron-vitamin D 
      co-supplementation does not yield added benefits for improvement of bone 
      turnover, inflammatory, oxidative stress, and metabolic markers, whereas, vitamin 
      D alone may have some detrimental effects on inflammatory and metabolic markers. 
      IRCT registration number: IRCT201409082365N9.
FAU - Abiri, Behnaz
AU  - Abiri B
AD  - Department of Nutrition, Faculty of Paramedicine, Ahvaz Jundishapur University of 
      Medical Sciences, Ahvaz, Iran.
FAU - Vafa, Mohammadreza
AU  - Vafa M
AD  - Department of Nutrition, School of Public Health, Iran University of Medical 
      Sciences, Shahid Hemmat Highway, Tehran, P.O.BOX: 1449614535, Iran. 
      vafa.m@iums.ac.ir.
FAU - Azizi-Soleiman, Fatemeh
AU  - Azizi-Soleiman F
AD  - Department of Clinical Nutrition, School of Nutrition & Food Science, Isfahan 
      University of Medical Sciences, Isfahan, Iran.
FAU - Safavi, Morteza
AU  - Safavi M
AD  - Department of Clinical Nutrition, School of Nutrition & Food Science, Isfahan 
      University of Medical Sciences, Isfahan, Iran.
FAU - Kazemi, Seyyed Morteza
AU  - Kazemi SM
AD  - Bone, Joint, and Related Tissue Research Center, Akhtar Hospital, Shahid Beheshti 
      University of Medical Sciences, Tehran, Iran.
FAU - Salehi, Masood
AU  - Salehi M
AD  - Department of Biostatistics, School of Public Health, Iran University of Medical 
      Sciences, Tehran, Iran.
FAU - Zaeri, Farid
AU  - Zaeri F
AD  - Department of Biostatistics, Faculty of Paramedical Sciences, Shahid Beheshti 
      University of Medical Sciences, Tehran, Iran.
FAU - Sadeghi, Homa
AU  - Sadeghi H
AD  - School of Public Health, Department of Nutrition and Food Science, Texas Woman's 
      University, Denton Campus, Denton, TX, 76204, USA.
LA  - eng
GR  - Iran University of Medical Sciences/
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20200925
PL  - United States
TA  - Biol Trace Elem Res
JT  - Biological trace element research
JID - 7911509
RN  - 1406-16-2 (Vitamin D)
RN  - E1UOL152H7 (Iron)
SB  - IM
MH  - Bone Remodeling
MH  - *Dietary Supplements
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - *Iron
MH  - Oxidative Stress
MH  - Vitamin D
OTO - NOTNLM
OT  - Bone turnover
OT  - Inflammation
OT  - Iron
OT  - Oxidative stress
OT  - Vitamin D
EDAT- 2020/09/26 06:00
MHDA- 2021/06/23 06:00
CRDT- 2020/09/25 12:16
PHST- 2020/07/31 00:00 [received]
PHST- 2020/09/16 00:00 [accepted]
PHST- 2020/09/26 06:00 [pubmed]
PHST- 2021/06/23 06:00 [medline]
PHST- 2020/09/25 12:16 [entrez]
AID - 10.1007/s12011-020-02400-8 [pii]
AID - 10.1007/s12011-020-02400-8 [doi]
PST - ppublish
SO  - Biol Trace Elem Res. 2021 Jul;199(7):2590-2601. doi: 10.1007/s12011-020-02400-8. 
      Epub 2020 Sep 25.