PMID- 32976091
OWN - NLM
STAT- MEDLINE
DCOM- 20210625
LR  - 20210625
IS  - 1558-2531 (Electronic)
IS  - 0018-9294 (Linking)
VI  - 68
IP  - 4
DP  - 2021 Apr
TI  - How Alpha Rhythm Spatiotemporally Acts Upon the Thalamus-Default Mode Circuit in 
      Idiopathic Generalized Epilepsy.
PG  - 1282-1292
LID - 10.1109/TBME.2020.3026055 [doi]
AB  - GOAL: Idiopathic generalized epilepsy (IGE) represents generalized spike-wave 
      discharges (GSWD) and distributed changes in thalamocortical circuit. The purpose 
      of this study is to investigate how the ongoing alpha oscillation acts upon the 
      local temporal dynamics and spatial hyperconnectivity in epilepsy. METHODS: We 
      evaluated the spatiotemporal regulation of alpha oscillations in epileptic state 
      based on simultaneous EEG-fMRI recordings in 45 IGE patients. The alpha-BOLD 
      temporal consistency, as well as the effect of alpha power windows on dynamic 
      functional connectivity strength (dFCS) was analyzed. Then, stable 
      synchronization networks during GSWD were constructed, and the spatial 
      covariation with alpha-based network integration was investigated. RESULTS: 
      Increased temporal covariation was demonstrated between alpha power and BOLD 
      fluctuations in thalamus and distributed cortical regions in IGE. High alpha 
      power had inhibition effect on dFCS in healthy controls, while in epilepsy, high 
      alpha windows arose along with the enhancement of dFCS in thalamus, caudate and 
      some default mode network (DMN) regions. Moreover, synchronization networks in 
      GSWD-before, GSWD-onset and GSWD-after stages were constructed, and the 
      connectivity strength in prominent hub nodes (precuneus, thalamus) was associated 
      with the spatially disturbed alpha-based network integration. CONCLUSION: The 
      results indicated spatiotemporal regulation of alpha in epilepsy by means of the 
      increased power and decreased coherence communication. It provided links between 
      alpha rhythm and the altered temporal dynamics, as well as the hyperconnectivity 
      in thalamus-default mode circuit. SIGNIFICANCE: The combination between neural 
      oscillations and epileptic representations may be of clinical importance in terms 
      of seizure prediction and non-invasive interventions.
FAU - Qin, Yun
AU  - Qin Y
FAU - Zhang, Nan
AU  - Zhang N
FAU - Chen, Yan
AU  - Chen Y
FAU - Tan, Yue
AU  - Tan Y
FAU - Dong, Li
AU  - Dong L
FAU - Xu, Peng
AU  - Xu P
FAU - Guo, Daqing
AU  - Guo D
FAU - Zhang, Tao
AU  - Zhang T
FAU - Yao, Dezhong
AU  - Yao D
FAU - Luo, Cheng
AU  - Luo C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210318
PL  - United States
TA  - IEEE Trans Biomed Eng
JT  - IEEE transactions on bio-medical engineering
JID - 0012737
RN  - Epilepsy, Idiopathic Generalized
SB  - IM
MH  - *Alpha Rhythm
MH  - Brain Mapping
MH  - *Electroencephalography
MH  - Epilepsy, Generalized
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Nerve Net/diagnostic imaging
MH  - Thalamus/diagnostic imaging
EDAT- 2020/09/26 06:00
MHDA- 2021/06/29 06:00
CRDT- 2020/09/25 17:10
PHST- 2020/09/26 06:00 [pubmed]
PHST- 2021/06/29 06:00 [medline]
PHST- 2020/09/25 17:10 [entrez]
AID - 10.1109/TBME.2020.3026055 [doi]
PST - ppublish
SO  - IEEE Trans Biomed Eng. 2021 Apr;68(4):1282-1292. doi: 10.1109/TBME.2020.3026055. 
      Epub 2021 Mar 18.