PMID- 32977058
OWN - NLM
STAT- MEDLINE
DCOM- 20201230
LR  - 20201230
IS  - 1872-9649 (Electronic)
IS  - 1568-1637 (Linking)
VI  - 64
DP  - 2020 Dec
TI  - Promising biomarkers of human aging: In search of a multi-omics panel to 
      understand the aging process from a multidimensional perspective.
PG  - 101164
LID - S1568-1637(20)30299-3 [pii]
LID - 10.1016/j.arr.2020.101164 [doi]
AB  - The aging process has been linked to the occurrence of chronic diseases and 
      functional impairments, including cancer, sarcopenia, frailty, metabolic, 
      cardiovascular, and neurodegenerative diseases. Nonetheless, aging is highly 
      variable and heterogeneous and represents a challenge for its characterization. 
      In this sense, intrinsic capacity (IC) stands as a novel perspective by the World 
      Health Organization, which integrates the individual wellbeing, environment, and 
      risk factors to understand aging. However, there is a lack of quantitative and 
      qualitative attributes to define it objectively. Therefore, in this review we 
      attempt to summarize the most relevant and promising biomarkers described in 
      clinical studies at date over different molecular levels, including epigenomics, 
      transcriptomics, proteomics, metabolomics, and the microbiome. To aid 
      gerontologists, geriatricians, and biomedical researchers to understand the aging 
      process through the IC. Aging biomarkers reflect the physiological state of 
      individuals and the underlying mechanisms related to homeostatic changes 
      throughout an individual lifespan; they demonstrated that aging could be measured 
      independently of time (that may explain its heterogeneity) and to be helpful to 
      predict age-related syndromes and mortality. In summary, we highlight the areas 
      of opportunity and gaps of knowledge that must be addressed to fully integrate 
      biomedical findings into clinically useful tools and interventions.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Rivero-Segura, N A
AU  - Rivero-Segura NA
AD  - Direccion de Investigacion, Instituto Nacional de Geriatria, Mexico.
FAU - Bello-Chavolla, O Y
AU  - Bello-Chavolla OY
AD  - Direccion de Investigacion, Instituto Nacional de Geriatria, Mexico; Department 
      of Physiology, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico.
FAU - Barrera-Vazquez, O S
AU  - Barrera-Vazquez OS
AD  - Departamento de Famacologia, Facultad de Medicina, Universidad Nacional Autonoma 
      de Mexico, Mexico City, Mexico.
FAU - Gutierrez-Robledo, L M
AU  - Gutierrez-Robledo LM
AD  - Direccion General, Instituto Nacional de Geriatria, Mexico.
FAU - Gomez-Verjan, J C
AU  - Gomez-Verjan JC
AD  - Direccion de Investigacion, Instituto Nacional de Geriatria, Mexico. Electronic 
      address: carlosverjan@comunidad.unam.mx.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20200923
PL  - England
TA  - Ageing Res Rev
JT  - Ageing research reviews
JID - 101128963
RN  - 0 (Biomarkers)
SB  - IM
MH  - Aging
MH  - Biomarkers
MH  - Epigenomics
MH  - Humans
MH  - *Metabolomics
MH  - *Proteomics
OTO - NOTNLM
OT  - Biological-age
OT  - Biomarkers
OT  - Chronological age
OT  - Epigenetic clocks
OT  - Intrinsic capacity
OT  - Multiomics
EDAT- 2020/09/26 06:00
MHDA- 2020/12/31 06:00
CRDT- 2020/09/25 20:10
PHST- 2020/06/03 00:00 [received]
PHST- 2020/08/18 00:00 [revised]
PHST- 2020/08/26 00:00 [accepted]
PHST- 2020/09/26 06:00 [pubmed]
PHST- 2020/12/31 06:00 [medline]
PHST- 2020/09/25 20:10 [entrez]
AID - S1568-1637(20)30299-3 [pii]
AID - 10.1016/j.arr.2020.101164 [doi]
PST - ppublish
SO  - Ageing Res Rev. 2020 Dec;64:101164. doi: 10.1016/j.arr.2020.101164. Epub 2020 Sep 
      23.