PMID- 32977251
OWN - NLM
STAT- MEDLINE
DCOM- 20201216
LR  - 20201216
IS  - 1872-8421 (Electronic)
IS  - 0165-5728 (Linking)
VI  - 349
DP  - 2020 Dec 15
TI  - Early decrease in intermediate monocytes in peripheral blood is characteristic of 
      multiple system atrophy-cerebellar type.
PG  - 577395
LID - S0165-5728(20)30182-X [pii]
LID - 10.1016/j.jneuroim.2020.577395 [doi]
AB  - To identify biomarkers for multiple system atrophy-cerebellar type (MSA-C), we 
      used flow cytometry to measure surface marker expression of peripheral blood 
      monocytes from patients with MSA-C or hereditary spinocerebellar degeneration 
      (hSCD) and from healthy controls (HCs). The percentage of intermediate monocytes 
      was significantly lower in MSA-C patients than in hSCD patients and HCs and 
      showed significant positive correlations with disease duration and unified MSA 
      rating scale scores. The percentage of CD62L(+) intermediate monocytes was 
      significantly lower in MSA-C patients than in hSCD patients and HCs. Early 
      decrease of peripheral blood intermediate monocytes is characteristic of MSA-C 
      and is a biomarker.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Matsuse, Dai
AU  - Matsuse D
AD  - Department of Neurology, Neurological Institute, Graduate School of Medical 
      Sciences, Kyushu University, Fukuoka 812-8582, Japan. Electronic address: 
      matsuse@neuro.med.kyushu-u.ac.jp.
FAU - Yamasaki, Ryo
AU  - Yamasaki R
AD  - Department of Neurology, Neurological Institute, Graduate School of Medical 
      Sciences, Kyushu University, Fukuoka 812-8582, Japan. Electronic address: 
      ryoya@neuro.med.kyushu-u.ac.jp.
FAU - Maimaitijiang, Guzailiayi
AU  - Maimaitijiang G
AD  - Department of Neurology, Neurological Institute, Graduate School of Medical 
      Sciences, Kyushu University, Fukuoka 812-8582, Japan. Electronic address: 
      maimai@neuro.med.kyushu-u.ac.jp.
FAU - Yamaguchi, Hiroo
AU  - Yamaguchi H
AD  - Department of Neurology, Neurological Institute, Graduate School of Medical 
      Sciences, Kyushu University, Fukuoka 812-8582, Japan. Electronic address: 
      yhiroo@neuro.med.kyushu-u.ac.jp.
FAU - Masaki, Katsuhisa
AU  - Masaki K
AD  - Department of Neurology, Neurological Institute, Graduate School of Medical 
      Sciences, Kyushu University, Fukuoka 812-8582, Japan.
FAU - Isobe, Noriko
AU  - Isobe N
AD  - Department of Neurological Therapeutics, Neurological Institute, Graduate School 
      of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan. Electronic 
      address: kuroki@neuro.med.kyushu-u.ac.jp.
FAU - Matsushita, Takuya
AU  - Matsushita T
AD  - Department of Neurology, Neurological Institute, Graduate School of Medical 
      Sciences, Kyushu University, Fukuoka 812-8582, Japan. Electronic address: 
      matusita@neuro.med.kyushu-u.ac.jp.
FAU - Kira, Jun-Ichi
AU  - Kira JI
AD  - Department of Neurology, Neurological Institute, Graduate School of Medical 
      Sciences, Kyushu University, Fukuoka 812-8582, Japan; Translational Neuroscience 
      Center, Graduate School of Medicine, and School of Pharmacy at Fukuoka, 
      International University of Health and Welfare, 137-1 Enokizu, Ookawa, Fukuoka 
      831-8501, Japan; Department of Neurology, Brain and Nerve Center, Fukuoka Central 
      Hospital, International University of Health and Welfare, 2-6-11 Yakuin, 
      Chuou-ku, Fukuoka 810-0022, Japan. Electronic address: 
      kira@neuro.med.kyushu-u.ac.jp.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200920
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
SB  - IM
MH  - Aged
MH  - Cerebellum/*metabolism/*pathology
MH  - Female
MH  - Humans
MH  - Leukocytes, Mononuclear/metabolism
MH  - Male
MH  - Middle Aged
MH  - Monocytes/*metabolism
MH  - Multiple System Atrophy/*blood/*diagnosis
MH  - Olivopontocerebellar Atrophies/blood/diagnosis
OTO - NOTNLM
OT  - Biomarker
OT  - Intermediate monocyte
OT  - Monocyte
OT  - Multiple system atrophy
OT  - Surface marker
EDAT- 2020/09/26 06:00
MHDA- 2020/12/17 06:00
CRDT- 2020/09/25 20:18
PHST- 2020/03/20 00:00 [received]
PHST- 2020/09/12 00:00 [revised]
PHST- 2020/09/12 00:00 [accepted]
PHST- 2020/09/26 06:00 [pubmed]
PHST- 2020/12/17 06:00 [medline]
PHST- 2020/09/25 20:18 [entrez]
AID - S0165-5728(20)30182-X [pii]
AID - 10.1016/j.jneuroim.2020.577395 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2020 Dec 15;349:577395. doi: 10.1016/j.jneuroim.2020.577395. Epub 
      2020 Sep 20.