PMID- 32978034
OWN - NLM
STAT- MEDLINE
DCOM- 20220614
LR  - 20230502
IS  - 1573-2509 (Electronic)
IS  - 0920-9964 (Print)
IS  - 0920-9964 (Linking)
VI  - 243
DP  - 2022 May
TI  - Neurocognitive and social cognitive training for youth at clinical high risk 
      (CHR) for psychosis: A randomized controlled feasibility trial.
PG  - 302-306
LID - S0920-9964(20)30461-8 [pii]
LID - 10.1016/j.schres.2020.09.005 [doi]
AB  - BACKGROUND: Cognitive deficits are present in individuals at clinical high risk 
      for psychosis (CHRP). We developed Cognition for Learning and for Understanding 
      Everyday Social Situations (CLUES), an integrated social- and neurocognitive 
      remediation intervention for CHRP, and examined its feasibility and efficacy 
      compared to an active control intervention in a pilot randomized controlled 
      trial. METHOD: Thirty-eight individuals at CHR-P were randomized to CLUES or 
      Enriched Acceptance and Commitment Therapy (EnACT). Participants were assessed at 
      baseline, end of treatment and 3-month follow-up for changes in social/role 
      functioning, neuro- and social cognition, and symptoms. RESULTS: Social 
      functioning significantly improved for participants in CLUES over EnACT, at end 
      of treatment and 3-month follow-up. CLUES participants also showed greater 
      improvements in social cognition (theory of mind and managing emotions). 
      CONCLUSION: The results support feasibility of CLUES and suggest preliminary 
      efficacy. Future randomized controlled trials of CLUES in a larger sample, with 
      additional treatment sites, could help determine efficacy of CLUES, and 
      investigate whether CLUES can be effectively implemented in other settings.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Friedman-Yakoobian, Michelle S
AU  - Friedman-Yakoobian MS
AD  - Public Psychiatry Division of Department of Psychiatry, Harvard Medical School at 
      Beth Israel Deaconess Medical Center, 75 Fenwood Road, Boston, MA 02115, United 
      States of America. Electronic address: mfriedm3@bidmc.harvard.edu.
FAU - Parrish, Emma M
AU  - Parrish EM
AD  - Public Psychiatry Division of Department of Psychiatry, Harvard Medical School at 
      Beth Israel Deaconess Medical Center, 75 Fenwood Road, Boston, MA 02115, United 
      States of America.
FAU - Eack, Shaun M
AU  - Eack SM
AD  - University of Pittsburgh, School of Social Work and Department of Psychiatry, 
      United States of America.
FAU - Keshavan, Matcheri S
AU  - Keshavan MS
AD  - Public Psychiatry Division of Department of Psychiatry, Harvard Medical School at 
      Beth Israel Deaconess Medical Center, 75 Fenwood Road, Boston, MA 02115, United 
      States of America.
LA  - eng
GR  - R34 MH105596/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20200922
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
SB  - IM
MH  - *Acceptance and Commitment Therapy
MH  - Adolescent
MH  - Cognition
MH  - Feasibility Studies
MH  - Humans
MH  - *Psychotic Disorders/psychology/therapy
MH  - Randomized Controlled Trials as Topic
MH  - *Schizophrenia/therapy
MH  - Social Cognition
PMC - PMC7982348
MID - NIHMS1631912
OTO - NOTNLM
OT  - Acceptance and commitment therapy
OT  - Clinical high risk for psychosis
OT  - Cognitive remediation
OT  - Randomized controlled trial
OT  - Schizophrenia
OT  - Treatment
EDAT- 2020/09/27 06:00
MHDA- 2022/06/15 06:00
PMCR- 2023/05/01
CRDT- 2020/09/26 05:23
PHST- 2019/09/23 00:00 [received]
PHST- 2020/06/28 00:00 [revised]
PHST- 2020/09/08 00:00 [accepted]
PHST- 2020/09/27 06:00 [pubmed]
PHST- 2022/06/15 06:00 [medline]
PHST- 2020/09/26 05:23 [entrez]
PHST- 2023/05/01 00:00 [pmc-release]
AID - S0920-9964(20)30461-8 [pii]
AID - 10.1016/j.schres.2020.09.005 [doi]
PST - ppublish
SO  - Schizophr Res. 2022 May;243:302-306. doi: 10.1016/j.schres.2020.09.005. Epub 2020 
      Sep 22.