PMID- 32980534
OWN - NLM
STAT- MEDLINE
DCOM- 20210115
LR  - 20210115
IS  - 1873-2585 (Electronic)
IS  - 1047-2797 (Linking)
VI  - 52
DP  - 2020 Dec
TI  - The impact of metformin on survival in patients with melanoma-national cohort 
      study.
PG  - 23-25
LID - S1047-2797(20)30380-X [pii]
LID - 10.1016/j.annepidem.2020.09.010 [doi]
AB  - PURPOSE: The primary study outcome was melanoma-specific mortality in patients 
      with type 2 diabetes mellitus (T2DM) using metformin. METHODS: Data regarding 
      patients were provided by the Lithuanian Cancer Registry and were linked with 
      National Health Insurance Fund in accordance with unique personal identification 
      numbers during the period of thirteen years. RESULTS: About 2817 patients met 
      eligibility criteria and were included in the retrospective cohort study. About 
      163 patients had pre-existing T2DM and 103 of them were treated with metformin. 
      In the multivariable analysis, there was significant risk difference in 
      melanoma-specific survival between diabetic, metformin-using patients, and 
      nondiabetic patients (P=0.02) in favor of metformin users. CONCLUSION: Melanoma 
      patients with T2DM treated with metformin had lower risk of melanoma-specific 
      mortality; however, prospective controlled studies are mandatory to confirm this 
      finding.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Urbonas, Vincas
AU  - Urbonas V
AD  - Clinic of Internal Diseases, Family Medicine and Oncology, Institute of Clinical 
      Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania; Laboratory 
      of Clinical Oncology, National Cancer Institute, Vilnius, Lithuania. Electronic 
      address: vincas.urbonas@nvi.lt.
FAU - Rutenberge, Julija
AU  - Rutenberge J
AD  - Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
FAU - Patasius, Ausvydas
AU  - Patasius A
AD  - Laboratory of Cancer Epidemiology, National Cancer Institute, Vilnius, Lithuania; 
      Department of Public Health, Institute of Health Sciences, Faculty of Medicine, 
      Vilnius, Lithuania.
FAU - Dulskas, Audrius
AU  - Dulskas A
AD  - Department of Abdominal and General Surgery and Oncology, National Cancer 
      Institute, Vilnius, Lithuania; Faculty of Health Care, University of Applied 
      Sciences, Vilnius, Lithuania; Institute of Clinical Medicine, Faculty of 
      Medicine, Vilnius University, Vilnius, Lithuania.
FAU - Burokiene, Neringa
AU  - Burokiene N
AD  - Clinic of Internal Diseases, Family Medicine and Oncology, Institute of Clinical 
      Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
FAU - Smailyte, Giedre
AU  - Smailyte G
AD  - Laboratory of Cancer Epidemiology, National Cancer Institute, Vilnius, Lithuania; 
      Department of Public Health, Institute of Health Sciences, Faculty of Medicine, 
      Vilnius, Lithuania.
LA  - eng
PT  - Journal Article
DEP - 20200924
PL  - United States
TA  - Ann Epidemiol
JT  - Annals of epidemiology
JID - 9100013
RN  - 0 (Hypoglycemic Agents)
RN  - 9100L32L2N (Metformin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/*complications/*drug therapy/epidemiology
MH  - Female
MH  - Humans
MH  - Hypoglycemic Agents/*therapeutic use
MH  - Kaplan-Meier Estimate
MH  - Lithuania/epidemiology
MH  - Male
MH  - Melanoma/complications/*mortality
MH  - Metformin/*therapeutic use
MH  - Middle Aged
MH  - Population Surveillance
MH  - Retrospective Studies
MH  - Survival Rate
OTO - NOTNLM
OT  - Diabetes
OT  - Melanoma
OT  - Metformin
OT  - Survival
EDAT- 2020/09/28 06:00
MHDA- 2021/01/16 06:00
CRDT- 2020/09/27 20:24
PHST- 2020/04/08 00:00 [received]
PHST- 2020/09/07 00:00 [revised]
PHST- 2020/09/16 00:00 [accepted]
PHST- 2020/09/28 06:00 [pubmed]
PHST- 2021/01/16 06:00 [medline]
PHST- 2020/09/27 20:24 [entrez]
AID - S1047-2797(20)30380-X [pii]
AID - 10.1016/j.annepidem.2020.09.010 [doi]
PST - ppublish
SO  - Ann Epidemiol. 2020 Dec;52:23-25. doi: 10.1016/j.annepidem.2020.09.010. Epub 2020 
      Sep 24.