PMID- 32981201
OWN - NLM
STAT- MEDLINE
DCOM- 20210624
LR  - 20210624
IS  - 2162-3279 (Electronic)
VI  - 10
IP  - 12
DP  - 2020 Dec
TI  - High neutrophil-to-lymphocyte ratio is a predictor of poor short-term outcome in 
      patients with mild acute ischemic stroke receiving intravenous thrombolysis.
PG  - e01857
LID - 10.1002/brb3.1857 [doi]
LID - e01857
AB  - INTRODUCTION: Very few studies have investigated the specific relationship 
      between neutrophil-to-lymphocyte ratio (NLR) and the short-term outcomes of 
      patients suffering from mild acute ischemic stroke (AIS) and receiving 
      intravenous thrombolysis (IVT). This study aimed to investigate whether a high 
      NLR is associated with a poor short-term outcome in patients with mild AIS after 
      IVT. METHODS: We retrospectively analyzed data that were prospectively acquired 
      from patients with AIS treated with IVT. Mild AIS was defined as a National 
      Institutes of Health Stroke Scale (NIHSS) score </= 7 on admission. The NLR was 
      based on a blood test performed prior to IVT and was classified as 'high' when 
      exceeding the 75th percentile. Follow-ups were performed at discharge and 
      3 months after onset. A poor outcome was defined as a modified Rankin scale (mRS) 
      >/=3. RESULTS: A total of 192 patients were included in this study. The median NLR 
      was 3.0 (interquartile range [IQR]: 2.0-3.9). Fifty-one patients (26.6%) had a 
      high NLR (>/=3.9) on admission. Forty-one patients (21.4%) had a poor outcome at 
      discharge, while 34 patients (17.7%) had a poor outcome at 3 months. Patients 
      with a poor outcome at discharge, and at 3 months after onset, were more likely 
      to have a high NLR at discharge (42.9% vs. 21.9%; p = .005) and at 3 months 
      (44.1% vs. 22.8%; p = .011), compared with those with a better outcome. After 
      adjustment for NIHSS score on admission, ipsilateral severe intracranial large 
      artery occlusion, and atrial fibrillation, logistic regression analyses revealed 
      that a high NLR was a significant predictor of poor outcome at discharge and at 
      3 months after onset. CONCLUSIONS: A high NLR on admission could be a useful 
      marker for predicting poor short-term outcome in patients with mild AIS following 
      IVT.
CI  - (c) 2020 The Authors. Brain and Behavior published by Wiley Periodicals LLC.
FAU - Liu, Yong-Lin
AU  - Liu YL
AUID- ORCID: 0000-0002-6204-4231
AD  - Department of Neurology, Dongguan People's Hospital (Affiliated Dongguan 
      Hospital, South Medical University), Dongguan, China.
FAU - Wu, Zhi-Qiang
AU  - Wu ZQ
AD  - Department of Neurology, Dongguan People's Hospital (Affiliated Dongguan 
      Hospital, South Medical University), Dongguan, China.
FAU - Qu, Jian-Feng
AU  - Qu JF
AD  - Department of Neurology, Dongguan People's Hospital (Affiliated Dongguan 
      Hospital, South Medical University), Dongguan, China.
FAU - Qiu, Dong-Hai
AU  - Qiu DH
AD  - Department of Neurology, Dongguan People's Hospital (Affiliated Dongguan 
      Hospital, South Medical University), Dongguan, China.
FAU - Luo, Gen-Pei
AU  - Luo GP
AD  - Department of Neurology, Dongguan People's Hospital (Affiliated Dongguan 
      Hospital, South Medical University), Dongguan, China.
FAU - Yin, Han-Peng
AU  - Yin HP
AD  - Department of Neurology, Dongguan People's Hospital (Affiliated Dongguan 
      Hospital, South Medical University), Dongguan, China.
FAU - Fang, Xue-Wen
AU  - Fang XW
AD  - Department of Radiology, Dongguan People's Hospital, Dongguan, China.
FAU - Wang, Fang
AU  - Wang F
AD  - Department of Radiology, Dongguan People's Hospital, Dongguan, China.
FAU - Chen, Yang-Kun
AU  - Chen YK
AUID- ORCID: 0000-0001-7619-6706
AD  - Department of Neurology, Dongguan People's Hospital (Affiliated Dongguan 
      Hospital, South Medical University), Dongguan, China.
LA  - eng
GR  - A2018322/Medical Scientific Research Foundation of Guangdong Province, China/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200927
PL  - United States
TA  - Brain Behav
JT  - Brain and behavior
JID - 101570837
SB  - IM
MH  - *Brain Ischemia/drug therapy
MH  - Humans
MH  - *Ischemic Stroke
MH  - Lymphocytes
MH  - Neutrophils
MH  - Retrospective Studies
MH  - *Stroke/drug therapy
MH  - Thrombolytic Therapy
MH  - Treatment Outcome
PMC - PMC7749577
OTO - NOTNLM
OT  - acute ischemic stroke
OT  - intravenous thrombolysis
OT  - neutrophil-to-lymphocyte ratio
OT  - outcome
COIS- None declared.
EDAT- 2020/09/28 06:00
MHDA- 2021/06/25 06:00
PMCR- 2020/09/27
CRDT- 2020/09/27 20:40
PHST- 2020/04/30 00:00 [received]
PHST- 2020/08/24 00:00 [revised]
PHST- 2020/09/09 00:00 [accepted]
PHST- 2020/09/28 06:00 [pubmed]
PHST- 2021/06/25 06:00 [medline]
PHST- 2020/09/27 20:40 [entrez]
PHST- 2020/09/27 00:00 [pmc-release]
AID - BRB31857 [pii]
AID - 10.1002/brb3.1857 [doi]
PST - ppublish
SO  - Brain Behav. 2020 Dec;10(12):e01857. doi: 10.1002/brb3.1857. Epub 2020 Sep 27.