PMID- 32981333
OWN - NLM
STAT- MEDLINE
DCOM- 20201015
LR  - 20201218
IS  - 2324-7096 (Electronic)
IS  - 2324-7096 (Linking)
VI  - 8
DP  - 2020 Jan-Dec
TI  - A Case of Guillain-Barre Syndrome Associated With COVID-19.
PG  - 2324709620961198
LID - 10.1177/2324709620961198 [doi]
LID - 2324709620961198
AB  - A novel member of human RNA coronavirus, which is an enveloped betacoronavirus, 
      has been termed severe acute respiratory syndrome coronavirus-2 (SARS COV-2). The 
      illness caused by SARS COV-2 is referred to as the coronavirus disease 2019 
      (COVID-19). It is a highly contagious disease that has resulted in a global 
      pandemic. The clinical spectrum of COVID-19 ranges from asymptomatic illness to 
      acute respiratory distress syndrome, septic shock, multi-organ dysfunction, and 
      death. The most common symptoms include fever, fatigue, dry cough, dyspnea, and 
      diarrhea. Neurological manifestations have also been reported. However, the data 
      on the association of Guillain-Barre syndrome (GBS) with COVID-19 are scarce. We 
      report a rare case of a COVID-19-positive 36-year-old immunocompromised male who 
      presented with clinical features of GBS. His clinical examination showed 
      generalized weakness and hyporeflexia. The cerebrospinal fluid (CSF) analysis 
      showed albuminocytological dissociation. Intravenous immunoglobulin (IVIG) was 
      administered based on the high clinical suspicion of GBS. The patient's 
      neurological condition worsened with progression to bulbar weakness and 
      ultimately neuromuscular respiratory failure requiring mechanical ventilation. 
      His nerve conduction studies were consistent with demyelinating polyneuropathy. 
      He received five plasma exchange treatments and was successfully weaned from 
      mechanical ventilation. A brain and cervical spine magnetic resonance imaging was 
      obtained to rule out other causes, which was normal. COVID-19 is believed to 
      cause a dysregulated immune system, which likely plays an important role in the 
      neuropathogenesis of GBS.
FAU - Rajdev, Kartikeya
AU  - Rajdev K
AD  - University of Nebraska Medical Center, Omaha, NE, USA.
FAU - Victor, Navin
AU  - Victor N
AD  - University of Nebraska Medical Center, Omaha, NE, USA.
FAU - Buckholtz, Elaine S
AU  - Buckholtz ES
AD  - University of Nebraska Medical Center, Omaha, NE, USA.
FAU - Hariharan, Praveen
AU  - Hariharan P
AD  - University of Nebraska Medical Center, Omaha, NE, USA.
FAU - Saeed, Muhammad Ahsan
AU  - Saeed MA
AD  - University of Nebraska Medical Center, Omaha, NE, USA.
FAU - Hershberger, Daniel M
AU  - Hershberger DM
AD  - University of Nebraska Medical Center, Omaha, NE, USA.
FAU - Bista, Sabin
AU  - Bista S
AD  - University of Nebraska Medical Center, Omaha, NE, USA.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Investig Med High Impact Case Rep
JT  - Journal of investigative medicine high impact case reports
JID - 101624758
SB  - IM
MH  - Adult
MH  - *Betacoronavirus
MH  - Brain/diagnostic imaging
MH  - COVID-19
MH  - Coronavirus Infections/*complications/diagnosis/epidemiology
MH  - Diagnosis, Differential
MH  - Guillain-Barre Syndrome/diagnosis/*etiology/therapy
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Pandemics
MH  - Plasma Exchange/methods
MH  - Pneumonia, Viral/*complications/diagnosis/epidemiology
MH  - SARS-CoV-2
PMC - PMC7545753
OTO - NOTNLM
OT  - COVID-19
OT  - GBS
OT  - Guillain-Barre syndrome
OT  - respiratory failure
COIS- Declaration of Conflicting Interests: The author(s) declared no potential 
      conflicts of interest with respect to the research, authorship, and/or 
      publication of this article.
EDAT- 2020/09/29 06:00
MHDA- 2020/10/21 06:00
PMCR- 2020/09/28
CRDT- 2020/09/28 05:26
PHST- 2020/09/28 05:26 [entrez]
PHST- 2020/09/29 06:00 [pubmed]
PHST- 2020/10/21 06:00 [medline]
PHST- 2020/09/28 00:00 [pmc-release]
AID - 10.1177_2324709620961198 [pii]
AID - 10.1177/2324709620961198 [doi]
PST - ppublish
SO  - J Investig Med High Impact Case Rep. 2020 Jan-Dec;8:2324709620961198. doi: 
      10.1177/2324709620961198.