PMID- 32981813
OWN - NLM
STAT- MEDLINE
DCOM- 20211124
LR  - 20211124
IS  - 1873-460X (Electronic)
IS  - 1056-8727 (Linking)
VI  - 34
IP  - 12
DP  - 2020 Dec
TI  - Increased plasma miR-146a levels are associated with subclinical atherosclerosis 
      in newly diagnosed type 2 diabetes mellitus.
PG  - 107725
LID - S1056-8727(20)30500-6 [pii]
LID - 10.1016/j.jdiacomp.2020.107725 [doi]
AB  - AIMS: The association between circulating miR-146a and subclinical 
      atherosclerosis in type 2 diabetes mellitus (T2DM) remains poorly understood. 
      This study aimed to investigate the correlation between plasma miR-146a levels 
      and subclinical atherosclerosis as measured by the carotid intima-media thickness 
      (CIMT) and brachial-ankle pulse wave velocity (baPWV) in patients with newly 
      diagnosed T2DM. METHODS: We studied 100 patients with newly diagnosed T2DM. 
      Subclinical atherosclerosis was defined as a thickened CIMT (>/=1.0 mm) and high 
      baPWV defined as a value greater than the 75th percentile. Plasma miR-146a levels 
      and metabolic parameters were measured. RESULTS: Patients with thickened CIMT had 
      higher plasma miR-146a levels than those without thickened CIMT (3.36 +/- 1.32 vs 
      1.38 +/- 1.11, P < 0.001). Patients in the high baPWV group had higher plasma 
      miR-146a levels than those in the normal baPWV group (3.43 +/- 1.32 vs 1.98 +/- 1.48, 
      P < 0.001). Both CIMT (beta = 0.569, P < 0.001) and baPWV (beta = 0.274, P = 0.001) 
      positively correlated with plasma miR-146a levels after adjustment for 
      confounding factors by multiple stepwise regression. On binary logistic 
      regression, plasma miR-146a level was an independent risk factor for thickened 
      CIMT (OR = 3.890, 95% CI 1.415-7.698, P = 0.008) and high baPWV (OR = 1.954, 95% 
      CI 1.256-3.040, P = 0.002) after adjustment for established cardiovascular risk 
      factors. The area under the receiver operating characteristics curve (AUROC) of 
      plasma miR-146a level for predicting thickened CIMT was 0.795 (95%CI 0.708-0.883, 
      P < 0.001) and for predicting high baPWV was 0.773 (95%CI 0.679-0.867, 
      P < 0.001). CONCLUSION: Plasma miR-146a levels correlate with CIMT and baPWV and 
      could act as a biomarker for early diagnosis and as a therapeutic target for 
      atherosclerosis in T2DM.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Guo, Wen
AU  - Guo W
AD  - Department of Health Promotion Center, The First Affiliated Hospital with Nanjing 
      Medical University, Nanjing 210029, China.
FAU - Li, Xiao-Na
AU  - Li XN
AD  - Department of Health Promotion Center, The First Affiliated Hospital with Nanjing 
      Medical University, Nanjing 210029, China.
FAU - Li, Jie
AU  - Li J
AD  - Department of Endocrinology, Nanjing Central Hospital, Nanjing 210018, China.
FAU - Lu, Jing
AU  - Lu J
AD  - Department of Health Promotion Center, The First Affiliated Hospital with Nanjing 
      Medical University, Nanjing 210029, China.
FAU - Wu, Juan
AU  - Wu J
AD  - Department of Health Promotion Center, The First Affiliated Hospital with Nanjing 
      Medical University, Nanjing 210029, China.
FAU - Zhu, Wen-Fang
AU  - Zhu WF
AD  - Department of Health Promotion Center, The First Affiliated Hospital with Nanjing 
      Medical University, Nanjing 210029, China.
FAU - Qin, Pei
AU  - Qin P
AD  - Department of Health Promotion Center, The First Affiliated Hospital with Nanjing 
      Medical University, Nanjing 210029, China. Electronic address: pqin1@ualberta.ca.
FAU - Xu, Nian-Zhen
AU  - Xu NZ
AD  - Department of Health Promotion Center, The First Affiliated Hospital with Nanjing 
      Medical University, Nanjing 210029, China.
FAU - Zhang, Qun
AU  - Zhang Q
AD  - Department of Health Promotion Center, The First Affiliated Hospital with Nanjing 
      Medical University, Nanjing 210029, China. Electronic address: 
      wenzi20100305@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200826
PL  - United States
TA  - J Diabetes Complications
JT  - Journal of diabetes and its complications
JID - 9204583
RN  - 0 (MIRN146 microRNA, human)
RN  - 0 (MicroRNAs)
SB  - IM
MH  - Ankle Brachial Index
MH  - *Atherosclerosis/complications/diagnosis
MH  - Carotid Intima-Media Thickness
MH  - *Diabetes Mellitus, Type 2/complications/diagnosis
MH  - Humans
MH  - *MicroRNAs/blood
MH  - Pulse Wave Analysis
MH  - Risk Factors
OTO - NOTNLM
OT  - CIMT
OT  - Early atherosclerosis
OT  - Type 2 diabetes
OT  - baPWV
OT  - miR-146a
EDAT- 2020/09/29 06:00
MHDA- 2021/11/25 06:00
CRDT- 2020/09/28 05:34
PHST- 2020/05/11 00:00 [received]
PHST- 2020/08/02 00:00 [revised]
PHST- 2020/08/23 00:00 [accepted]
PHST- 2020/09/29 06:00 [pubmed]
PHST- 2021/11/25 06:00 [medline]
PHST- 2020/09/28 05:34 [entrez]
AID - S1056-8727(20)30500-6 [pii]
AID - 10.1016/j.jdiacomp.2020.107725 [doi]
PST - ppublish
SO  - J Diabetes Complications. 2020 Dec;34(12):107725. doi: 
      10.1016/j.jdiacomp.2020.107725. Epub 2020 Aug 26.