PMID- 32981880
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210219
IS  - 2210-2612 (Print)
IS  - 2210-2612 (Electronic)
IS  - 2210-2612 (Linking)
VI  - 77S
IP  - Suppl
DP  - 2020
TI  - Duodenal perforation as presentation of gastric neuroendocrine tumour: A case 
      report.
PG  - S105-S108
LID - S2210-2612(20)30793-8 [pii]
LID - 10.1016/j.ijscr.2020.09.120 [doi]
AB  - INTRODUCTION: Neuroendocrine tumors (NETs) represent uncommon neoplasms with 
      different characteristics. They can be asymptomatic and benign or they can also 
      proliferate and manifest themselves with neoplastic mass symptoms such as 
      intestinal occlusion or with carcinoid syndrome. Gastric neuroendocrine neoplasms 
      (g-NENs) are the most frequent digestive NENs while duodenal neuroendocrine 
      neoplasms (d-NENs) may be sporadic or associated with multiple endocrine 
      neoplasia type 1 (MEN-1) and present a functional syndrome (e.g. gastrinoma with 
      Zollinger-Ellison syndrome). PRESENTATION OF CASE: We report a case of duodenal 
      perforation due to a unknown gastrinoma responsible of Zollinger-Ellison 
      Syndrome. He underwent an emergency contrast enhanced CT abdominal scan that 
      showed a perforation. We performed a distal gastrectomy. The histopathological 
      examination revealed a g-NET configuring a possible picture of Zollinger-Ellison 
      Syndrome. DISCUSSION: The management of NETs is diffulcult and controversial 
      because of their rarity. It is useful to know the pathologic assessment of tumor 
      differentiation and/or grade, evaluate surgical resectability and control the 
      carcinoid syndrome symptoms. CONCLUSION: This case report shows that gastric NETs 
      can be found in cases of duodenal perforation. Our future goal is to evaluate the 
      possibilities to diagnose the Zollinger Ellison Syndrome as early as possible and 
      to treat it with targeted therapy in order to prevent its related complications.
CI  - Copyright (c) 2020. Published by Elsevier Ltd.
FAU - Di Buono, Giuseppe
AU  - Di Buono G
AD  - Department of Surgical, Oncological and Oral Sciences, Section of General and 
      Urgent Surgery, University of Palermo, Italy. Electronic address: 
      giuseppe.dibuono@unipa.it.
FAU - Bonventre, Giulia
AU  - Bonventre G
AD  - Department of Surgical, Oncological and Oral Sciences, Section of General and 
      Urgent Surgery, University of Palermo, Italy. Electronic address: 
      giulia.bonv@gmail.com.
FAU - Badalamenti, Giuseppe
AU  - Badalamenti G
AD  - Department of Surgical, Oncological and Oral Sciences, Section of Oncology, 
      University of Palermo, Italy. Electronic address: giuseppe.badalamenti@unipa.it.
FAU - Buscemi, Salvatore
AU  - Buscemi S
AD  - Department of Surgical, Oncological and Oral Sciences, Section of General and 
      Urgent Surgery, University of Palermo, Italy. Electronic address: 
      buscemi.salvatore@gmail.com.
FAU - Romano, Giorgio
AU  - Romano G
AD  - Department of Surgical, Oncological and Oral Sciences, Section of General and 
      Urgent Surgery, University of Palermo, Italy. Electronic address: 
      giorgio.romano@unipa.it.
FAU - Agrusa, Antonino
AU  - Agrusa A
AD  - Department of Surgical, Oncological and Oral Sciences, Section of General and 
      Urgent Surgery, University of Palermo, Italy. Electronic address: 
      antonino.agrusa@unipa.it.
LA  - eng
PT  - Case Reports
DEP - 20200919
PL  - Netherlands
TA  - Int J Surg Case Rep
JT  - International journal of surgery case reports
JID - 101529872
PMC - PMC7876995
OTO - NOTNLM
OT  - Emergency surgery
OT  - Exploratory laparoscopy
OT  - Gastric NET
OT  - Gastric perforation
EDAT- 2020/09/29 06:00
MHDA- 2020/09/29 06:01
PMCR- 2020/09/19
CRDT- 2020/09/28 05:35
PHST- 2020/07/04 00:00 [received]
PHST- 2020/09/08 00:00 [revised]
PHST- 2020/09/15 00:00 [accepted]
PHST- 2020/09/29 06:00 [pubmed]
PHST- 2020/09/29 06:01 [medline]
PHST- 2020/09/28 05:35 [entrez]
PHST- 2020/09/19 00:00 [pmc-release]
AID - S2210-2612(20)30793-8 [pii]
AID - 10.1016/j.ijscr.2020.09.120 [doi]
PST - ppublish
SO  - Int J Surg Case Rep. 2020;77S(Suppl):S105-S108. doi: 10.1016/j.ijscr.2020.09.120. 
      Epub 2020 Sep 19.