PMID- 32982357
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220417
IS  - 1178-7007 (Print)
IS  - 1178-7007 (Electronic)
IS  - 1178-7007 (Linking)
VI  - 13
DP  - 2020
TI  - The Correlation of Type 2 Diabetes Status with Bone Mineral Density in 
      Middle-Aged Adults.
PG  - 3269-3276
LID - 10.2147/DMSO.S268592 [doi]
AB  - BACKGROUND: Bone metabolism can be influenced by type 2 diabetes mellitus (T2DM). 
      However, the relationship between T2DM and bone mineral density (BMD) remains 
      inconsistent. This study explored the differences in BMD in middle-aged adults 
      with and without T2DM. METHODS: We conducted a cross-sectional study of 4986 
      participants aged 40-59 years who participated in the National Health and 
      Nutrition Examination Survey (NHANES) 2011-2018. We performed multivariable 
      logistic regression models to evaluate the associations between T2DM status, 
      serum glucose, glycohemoglobin (HbA1c), disease duration and lumbar BMD. RESULTS: 
      There was a positive association between T2DM status and lumbar BMD in all three 
      models (model 1: beta=0.039, 95% CI: 0.025-0.052; model 2: beta=0.045, 95% CI: 
      0.031-0.059; model 3: beta=0.035, 95% CI: 0.014-0.055). In the subgroup analysis 
      stratified by gender, this positive association existed in both gender after 
      adjusting for confounders (males: beta=0.033, 95% CI: 0.003-0.062; females: beta=0.035, 
      95% CI: 0.008-0.062). Besides, there were no significant associations of serum 
      glucose, HbA1c, disease duration with lumbar BMD in both genders with T2DM. 
      CONCLUSION: This study indicated that middle-aged adults with T2DM had 
      significantly higher lumbar BMD compared with those without DM.
CI  - (c) 2020 Yao et al.
FAU - Yao, Xiaocong
AU  - Yao X
AD  - Department of Osteoporosis Care and Control, The First People's Hospital of 
      Xiaoshan District, Hangzhou, Zhejiang 311200, People's Republic of China.
FAU - Xu, Xiaocheng
AU  - Xu X
AD  - Department of Cancer Medicine, The First People's Hospital of Xiaoshan District, 
      Hangzhou, Zhejiang 311200, People's Republic of China.
FAU - Jin, Fang
AU  - Jin F
AD  - Department of Osteoporosis Care and Control, The First People's Hospital of 
      Xiaoshan District, Hangzhou, Zhejiang 311200, People's Republic of China.
FAU - Zhu, Zhongxin
AU  - Zhu Z
AD  - Department of Osteoporosis Care and Control, The First People's Hospital of 
      Xiaoshan District, Hangzhou, Zhejiang 311200, People's Republic of China.
AD  - Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, People's Republic 
      of China.
LA  - eng
PT  - Journal Article
DEP - 20200916
PL  - New Zealand
TA  - Diabetes Metab Syndr Obes
JT  - Diabetes, metabolic syndrome and obesity : targets and therapy
JID - 101515585
PMC - PMC7509476
OTO - NOTNLM
OT  - HbA1c
OT  - NHANES
OT  - bone health
OT  - diabetes
OT  - glucose
COIS- The authors report no conflicts of interest for this work.
EDAT- 2020/09/29 06:00
MHDA- 2020/09/29 06:01
PMCR- 2020/09/16
CRDT- 2020/09/28 05:37
PHST- 2020/06/20 00:00 [received]
PHST- 2020/08/19 00:00 [accepted]
PHST- 2020/09/28 05:37 [entrez]
PHST- 2020/09/29 06:00 [pubmed]
PHST- 2020/09/29 06:01 [medline]
PHST- 2020/09/16 00:00 [pmc-release]
AID - 268592 [pii]
AID - 10.2147/DMSO.S268592 [doi]
PST - epublish
SO  - Diabetes Metab Syndr Obes. 2020 Sep 16;13:3269-3276. doi: 10.2147/DMSO.S268592. 
      eCollection 2020.