PMID- 32982777
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240329
IS  - 1664-042X (Print)
IS  - 1664-042X (Electronic)
IS  - 1664-042X (Linking)
VI  - 11
DP  - 2020
TI  - Impact of Pre-operative Aerobic Exercise on Cardiometabolic Health and Quality of 
      Life in Patients Undergoing Bariatric Surgery.
PG  - 1018
LID - 10.3389/fphys.2020.01018 [doi]
LID - 1018
AB  - OBJECTIVE: Examine the effect of aerobic exercise (EX) combined with standard 
      medical care (SC) (EX + SC) compared to SC alone on cardiometabolic health and 
      quality of life in relation to surgical outcomes. METHODS: Patients receiving 
      bariatric surgery were match-paired to 30 days of pre-operative SC (n = 7, 1 
      male, 39.0 +/- 5.3 years, body mass index 46.4 +/- 3.0 kg/m(2); low calorie diet) or 
      EX + SC (n = 7, 0 males, 45.6 +/- 4.8 years, body mass index 43.9 +/- 4.2 kg/m(2); 
      walking 30 min/day, 5 days/week, 65-85% HR (peak) ). Body mass, waist 
      circumference, cardiorespiratory fitness (VO(2)peak), high sensitivity C-reactive 
      protein (hs-CRP), cytokeratin 18 (CK18), weight related quality of life (QoL), 
      and a 120 min mixed meal tolerance test (MMTT) was performed to assess arterial 
      stiffness via augmentation index normalized to a heart rate of 75 beats per 
      minute (AIx@75), whole-body insulin sensitivity, and glucose total area under the 
      curve (tAUC) pre- and post-intervention ( approximately 2 days prior to surgery). Length of 
      hospital stay (admission to discharge) was recorded. RESULTS: EX + SC had a 
      greater effect for decreased intake of total calories (P = 0.14; ES = 0.86) 
      compared to SC, but no change in body weight or waist circumference was observed 
      in either group. EX + SC had a greater effect for increased VO(2)peak (P = 0.24; 
      ES = 0.91) and decreased hs-CRP (P = 0.31; ES = 0.69) compared to SC. EX + SC 
      reduced circulating CK18 (P = 0.05; ES = 3.05) and improved QoL (P = 0.02) 
      compared to SC. Although EX + SC had no statistical effect on arterial stiffness 
      compared to SC, we observed a modest effect size for AIx@75 tAUC (P = 0.36; ES = 
      0.52). EX + SC had a significantly shorter length of hospital stay (P = 0.05; ES 
      = 1.38) than SC, and a shorter length of hospital stay was associated with 
      decreased sugar intake (r = 0.55, P = 0.04). Decreased AIx@75 tAUC significantly 
      correlated with improved whole-body insulin sensitivity (r = -0.59, P = 0.03) and 
      glucose tAUC (r = 0.57, P = 0.04). CONCLUSION: EX with SC for 30 days prior to 
      bariatric surgery may be important for cardiometabolic health, quality of life, 
      and surgical outcomes in the bariatric patient.
CI  - Copyright (c) 2020 Gilbertson, Eichner, Khurshid, Rexrode, Kranz, Weltman, 
      Hallowell and Malin.
FAU - Gilbertson, Nicole M
AU  - Gilbertson NM
AD  - Department of Kinesiology, University of Virginia, Charlottesville, VA, United 
      States.
FAU - Eichner, Natalie Z M
AU  - Eichner NZM
AD  - Department of Kinesiology, University of Virginia, Charlottesville, VA, United 
      States.
FAU - Khurshid, Mahnoor
AU  - Khurshid M
AD  - Department of Kinesiology, University of Virginia, Charlottesville, VA, United 
      States.
FAU - Rexrode, Elizabeth A
AU  - Rexrode EA
AD  - Department of Surgery, University of Virginia, Charlottesville, VA, United 
      States.
FAU - Kranz, Sibylle
AU  - Kranz S
AD  - Department of Kinesiology, University of Virginia, Charlottesville, VA, United 
      States.
FAU - Weltman, Arthur
AU  - Weltman A
AD  - Department of Kinesiology, University of Virginia, Charlottesville, VA, United 
      States.
AD  - Department of Medicine, University of Virginia, Charlottesville, VA, United 
      States.
FAU - Hallowell, Peter T
AU  - Hallowell PT
AD  - Department of Surgery, University of Virginia, Charlottesville, VA, United 
      States.
FAU - Malin, Steven K
AU  - Malin SK
AD  - Department of Kinesiology, University of Virginia, Charlottesville, VA, United 
      States.
AD  - Department of Medicine, University of Virginia, Charlottesville, VA, United 
      States.
AD  - Robert M. Berne Cardiovascular Research Center, University of Virginia, 
      Charlottesville, VA, United States.
LA  - eng
GR  - R01 HL130296/HL/NHLBI NIH HHS/United States
PT  - Journal Article
DEP - 20200826
PL  - Switzerland
TA  - Front Physiol
JT  - Frontiers in physiology
JID - 101549006
PMC - PMC7479188
OTO - NOTNLM
OT  - C-reactive protein
OT  - arterial stiffness
OT  - cytokeratin 18
OT  - dietary intake
OT  - physical activity
EDAT- 2020/09/29 06:00
MHDA- 2020/09/29 06:01
PMCR- 2020/08/26
CRDT- 2020/09/28 05:39
PHST- 2020/04/18 00:00 [received]
PHST- 2020/07/24 00:00 [accepted]
PHST- 2020/09/28 05:39 [entrez]
PHST- 2020/09/29 06:00 [pubmed]
PHST- 2020/09/29 06:01 [medline]
PHST- 2020/08/26 00:00 [pmc-release]
AID - 10.3389/fphys.2020.01018 [doi]
PST - epublish
SO  - Front Physiol. 2020 Aug 26;11:1018. doi: 10.3389/fphys.2020.01018. eCollection 
      2020.