PMID- 32983569
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220417
IS  - 2056-5623 (Print)
IS  - 2056-5623 (Electronic)
IS  - 2056-5623 (Linking)
VI  - 6
IP  - 8
DP  - 2020 Aug 10
TI  - Should we use extracorporeal photopheresis more often? Evidence from 
      graft-versus-host disease patients monitored with Treg as a biomarker.
PG  - FSO623
LID - 10.2144/fsoa-2020-0107 [doi]
LID - FSO623
AB  - BACKGROUND: Chronic graft-versus-host disease (cGvHD) is a major complication 
      after allogeneic hematopoietic cell transplantation. Extracorporeal photopheresis 
      (ECP) is an immunotherapy treatment for cGvHD, although suitable response 
      biomarkers are lacking. MATERIALS & METHODS: We analyzed data from six cGvHD 
      patients undergoing ECP at a reference center from 826 to 2866 days. Circulating 
      Tregs were enumerated, patient's clinical evolution, immunosuppression dose and 
      adverse events (AEs) registered. RESULTS: We observed an increase in Tregs, a 
      decrease in immunosuppression dosage and symptoms improvement. Mild AEs occurred 
      at a very low rate. CONCLUSION: In these patients, the improvement of cGvHD, with 
      low AEs, confirms a place for ECP as treatment. Improvements were accompanied by 
      an increase in circulating Tregs, suggesting their role as a biomarker.
CI  - (c) 2020 Sergio Machado Lopes.
FAU - Lopes, Sergio Machado
AU  - Lopes SM
AUID- ORCID: 0000-0002-4002-1071
AD  - Department of Cellular Therapy, Instituto Portugues de Oncologia do Porto, 
      4200-072, Porto, Portugal.
AD  - Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal.
FAU - Roncon, Susana
AU  - Roncon S
AD  - Department of Cellular Therapy, Instituto Portugues de Oncologia do Porto, 
      4200-072, Porto, Portugal.
FAU - Pinho, Ana Catarina
AU  - Pinho AC
AD  - Department of Cellular Therapy, Instituto Portugues de Oncologia do Porto, 
      4200-072, Porto, Portugal.
FAU - Bordalo, Filipa
AU  - Bordalo F
AD  - Department of Cellular Therapy, Instituto Portugues de Oncologia do Porto, 
      4200-072, Porto, Portugal.
FAU - Antunes, Luis
AU  - Antunes L
AUID- ORCID: 0000-0002-3098-0711
AD  - Department of Bone Marrow Transplant, Instituto Portugues de Oncologia do Porto, 
      4200-072, Porto, Portugal.
FAU - Campilho, Fernando
AU  - Campilho F
AD  - Department of Epidemiology, Instituto Portugues de Oncologia do Porto, 4200-072, 
      Porto, Portugal.
FAU - Campos, Antonio
AU  - Campos A
AD  - Department of Epidemiology, Instituto Portugues de Oncologia do Porto, 4200-072, 
      Porto, Portugal.
FAU - Costa-Pereira, Altamiro
AU  - Costa-Pereira A
AD  - Center for Health Technology & Services Research (CINTESIS), Department of 
      Community Medicine, Information & Health Decision Sciences (MEDCIDS), Faculty of 
      Medicine, University of Porto, 4200-319, Porto, Portugal.
LA  - eng
PT  - Journal Article
DEP - 20200810
PL  - England
TA  - Future Sci OA
JT  - Future science OA
JID - 101665030
PMC - PMC7491011
OTO - NOTNLM
OT  - ECP
OT  - GvHD
OT  - Treg
OT  - extracorporeal photopheresis
OT  - immunotherapy
COIS- Financial & competing interests disclosure The authors have no relevant 
      affiliations or financial involvement with any organization or entity with a 
      financial interest in or financial conflict with the subject matter or materials 
      discussed in the manuscript. This includes employment, consultancies, honoraria, 
      stock ownership or options, expert testimony, grants or patents received or 
      pending, or royalties. No writing assistance was utilized in the production of 
      this manuscript.
EDAT- 2020/09/29 06:00
MHDA- 2020/09/29 06:01
PMCR- 2020/08/10
CRDT- 2020/09/28 05:42
PHST- 2020/09/28 05:42 [entrez]
PHST- 2020/09/29 06:00 [pubmed]
PHST- 2020/09/29 06:01 [medline]
PHST- 2020/08/10 00:00 [pmc-release]
AID - 10.2144/fsoa-2020-0107 [doi]
PST - epublish
SO  - Future Sci OA. 2020 Aug 10;6(8):FSO623. doi: 10.2144/fsoa-2020-0107.