PMID- 32984204 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20201001 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 8 DP - 2020 TI - Factors Associated With In-hospital Mortality of Children With Acute Fulminant Myocarditis on Extracorporeal Membrane Oxygenation. PG - 488 LID - 10.3389/fped.2020.00488 [doi] LID - 488 AB - Aim: To analyze the factors associated with in-hospital mortality of children with acute fulminant myocarditis on venoarterial extracorporeal membrane oxygenation (VA-ECMO). Methods: This was a retrospective cohort study using chart reviews of patients diagnosed with acute fulminant myocarditis at the pediatric intensive care unit of two tertiary medical centers between January 1, 2005 and December 31, 2017. The inclusion criteria for this study were: (1) age from 1 month to 18 years; (2) diagnosed with acute myocarditis; (3) cardiogenic shock and need vasoactive-inotropic score >/=20 within 48 h after the use of vasoactive-inotropic agents; and (4) the need for ECMO placement. Results: Thirty-three children with acute fulminant myocarditis who needed ECMO were included. Clinical parameters were retrospectively reviewed. The overall survival rate was 69.6%. Higher levels of pre-ECMO troponin-I and pre-ECMO lactate, and lower post-ECMO left ventricular ejection fraction (LVEF) were significantly associated with in-hospital mortality in univariate analysis. Only higher pre-ECMO lactate and lower post-ECMO LVEF remained as predictors for in-hospital mortality in multivariate analysis. The areas under the curve of pre-ECMO lactate and post-ECMO LVEF in predicting survival were 0.848 (95% CI, 0.697-0.999, p = 0.002) and 0.824 (95% CI, 0.704-0.996, p = 0.01), respectively. A pre-ECMO lactate level of 79.8 mg/dL and post-ECMO LVEF of 39% were appropriate cutoff points to predict mortality. Conclusion: Pre-ECMO lactate level was associated with mortality in children with acute fulminant myocarditis, with an optimal cutoff value of 79.8 mg/dL. After VA-ECMO implantation, post-ECMO LVEF was associated with mortality, with an optimal cutoff value of 39%. The use of LVADs or urgent heart transplantation should be considered if the post-ECMO LVEF does not improve. CI - Copyright (c) 2020 Lee, Chu, Huang, Hsia, Chan, Lin, Su, Chang, Chung, Wu and Lin. FAU - Lee, En-Pei AU - Lee EP AD - Division of Pediatric Critical Care Medicine, and Pediatric Sepsis Study Group, Chang Gung Children's Hospital and Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan. AD - College of Medicine, Chang Gung University, Taoyuan, Taiwan. FAU - Chu, Sheng-Chih AU - Chu SC AD - College of Medicine, Chang Gung University, Taoyuan, Taiwan. AD - Division of Pediatric Cardiovascular Internal Medicine, Chang Gung Children's Hospital and Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan. AD - Department of Pediatrics, Taoyuan Armed Forces General Hospital, Taoyuan, Taiwan. AD - National Defense Medical Center, Taoyuan, Taiwan. FAU - Huang, Wun-Yan AU - Huang WY AD - Department of Pediatric Emergency Medicine, China Medical University Children Hospital, Taichung, Taiwan. AD - Department of Medicine, School of Medicine, China Medical University, Taichung, Taiwan. AD - Department of Medical Research, Children's Hospital, China Medical University, Taichung, Taiwan. FAU - Hsia, Shao-Hsuan AU - Hsia SH AD - Division of Pediatric Critical Care Medicine, and Pediatric Sepsis Study Group, Chang Gung Children's Hospital and Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan. AD - College of Medicine, Chang Gung University, Taoyuan, Taiwan. FAU - Chan, Oi-Wa AU - Chan OW AD - Division of Pediatric Critical Care Medicine, and Pediatric Sepsis Study Group, Chang Gung Children's Hospital and Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan. AD - College of Medicine, Chang Gung University, Taoyuan, Taiwan. FAU - Lin, Chia-Ying AU - Lin CY AD - Division of Pediatric Critical Care Medicine, and Pediatric Sepsis Study Group, Chang Gung Children's Hospital and Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan. AD - College of Medicine, Chang Gung University, Taoyuan, Taiwan. FAU - Su, Ya-Ting AU - Su YT AD - College of Medicine, Chang Gung University, Taoyuan, Taiwan. FAU - Chang, Yu-Sheng AU - Chang YS AD - College of Medicine, Chang Gung University, Taoyuan, Taiwan. AD - Division of Cardiovascular Surgery, Chang Gung Children's Hospital and Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan. FAU - Chung, Hung-Tao AU - Chung HT AD - College of Medicine, Chang Gung University, Taoyuan, Taiwan. AD - Division of Pediatric Cardiovascular Internal Medicine, Chang Gung Children's Hospital and Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan. FAU - Wu, Han-Ping AU - Wu HP AD - Department of Pediatric Emergency Medicine, China Medical University Children Hospital, Taichung, Taiwan. AD - Department of Medicine, School of Medicine, China Medical University, Taichung, Taiwan. AD - Department of Medical Research, Children's Hospital, China Medical University, Taichung, Taiwan. FAU - Lin, Jainn-Jim AU - Lin JJ AD - Division of Pediatric Critical Care Medicine, and Pediatric Sepsis Study Group, Chang Gung Children's Hospital and Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan. AD - College of Medicine, Chang Gung University, Taoyuan, Taiwan. LA - eng PT - Journal Article DEP - 20200827 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC7481354 OTO - NOTNLM OT - VA-ECMO OT - acute fulminant myocarditis OT - children OT - mortality OT - predictors EDAT- 2020/09/29 06:00 MHDA- 2020/09/29 06:01 PMCR- 2020/08/27 CRDT- 2020/09/28 05:45 PHST- 2020/03/15 00:00 [received] PHST- 2020/07/13 00:00 [accepted] PHST- 2020/09/28 05:45 [entrez] PHST- 2020/09/29 06:00 [pubmed] PHST- 2020/09/29 06:01 [medline] PHST- 2020/08/27 00:00 [pmc-release] AID - 10.3389/fped.2020.00488 [doi] PST - epublish SO - Front Pediatr. 2020 Aug 27;8:488. doi: 10.3389/fped.2020.00488. eCollection 2020.