PMID- 32988370
OWN - NLM
STAT- MEDLINE
DCOM- 20210709
LR  - 20231112
IS  - 1472-6823 (Electronic)
IS  - 1472-6823 (Linking)
VI  - 20
IP  - 1
DP  - 2020 Sep 29
TI  - Association between circulating microRNAs 486, 146b and 15b and serum betatrophin 
      levels in obese; type 2 diabetic and non-diabetic children.
PG  - 145
LID - 10.1186/s12902-020-00628-y [doi]
LID - 145
AB  - BACKGROUND: This study tested the association between serum levels of 
      microRNA-486, -146b and -15b and betatrophin in normal and obese children 
      with/without type 2 diabetes mellitus (T2DM). METHODS: the study included 120 
      children; divided into three groups: G1 (50 healthy), G2 (35 obese) and G3 (35 
      obese with T2DM). The levels of microRNA-486, 146b and 15b and serum betatrophin 
      were measured by their corresponding methods. RESULTS: serum microRNA-486, -146b, 
      -15b and betatrophin levels were significantly high in G3 followed by G2 then G1 
      (p = 0.002, > 0.001, > 0.001, and > 0.001, respectively). Especially in G3, these 
      levels correlated positively with the BMI percentile (r = 0.44, 0.58, 0.38, and 
      0.46, p = 0.007, > 0.001, 0.021, and 0.005, respectively), serum glucose 
      (r = 0.56, 0.49, 0.82, 0.60, and 0.42, p > 0.001, 0.003, > 0.001, and > 0.001, 
      respectively) and HbA1c% (r = 0.56, 0.39, 0.66, and 0.42, p > 0.001, 0.019, 
      > 0.001, and 0.032, respectively) while, showed negative correlations with 
      correlated with serum insulin levels (r = - 0.37, - 0.42, - 0.58, and - 0.41, 
      p = 0.021, 0.012, > 0.001 and 0.013, respectively) and with serum C-peptide 
      levels (r = - 0.76, - 0.50, - 0.35 and - 0.42, p > 0.001, 0.002, 0.036 and 0.011, 
      respectively). Serum betatrophin levels correlated positively with microRNA-486, 
      -146b and -15b levels in G2 (r = 0.35, 0.80, and 0.67, p = 0.036, > 0.001, 
      and,> 0.001, respectively), and in G3 (r = 0.57, 0.36, and 0.38, p > 0.001, 0.029 
      and, 0.023, respectively). CONCLUSIONS: Circulating microRNA-486, 146b and 15b 
      increase significantly in obese children with T2DM and these levels correlate 
      positively with serum betatrophin levels. Further studies are required to test 
      the role of targeting of these microRNAs and betatrophin in the timely management 
      of obesity and/or T2DM in children.
FAU - Mohany, Khalid M
AU  - Mohany KM
AD  - Department of medical biochemistry, College of Medicine, Assiut University, 
      Assiut, Egypt. khalidmohany9@gmail.com.
AD  - Department of Basic Medical Sciences, Unaizah College of Medicine and Medical 
      Sciences, Qassim University, Unaizah, Saudi Arabia. khalidmohany9@gmail.com.
FAU - Al Rugaie, Osamah
AU  - Al Rugaie O
AD  - Department of Basic Medical Sciences, Unaizah College of Medicine and Medical 
      Sciences, Qassim University, Unaizah, Saudi Arabia.
FAU - Al-Wutayd, Osama
AU  - Al-Wutayd O
AD  - Department of Family and Community Medicine, Unaizah College of Medicine and 
      Medical Sciences, Qassim University, Unaizah, Saudi Arabia.
FAU - Al-Nafeesah, Abdullah
AU  - Al-Nafeesah A
AD  - Department of Pediatrics, Unaizah College of Medicine and Medical Sciences, 
      Qassim University, Unaizah, Saudi Arabia.
FAU - Saleem, Tahia H
AU  - Saleem TH
AD  - Department of medical biochemistry, College of Medicine, Assiut University, 
      Assiut, Egypt.
LA  - eng
GR  - 3366-mduc-2018-1-14-S/Qassim University/
PT  - Journal Article
DEP - 20200929
PL  - England
TA  - BMC Endocr Disord
JT  - BMC endocrine disorders
JID - 101088676
RN  - 0 (ANGPTL8 protein, human)
RN  - 0 (Angiopoietin-Like Protein 8)
RN  - 0 (Angiopoietin-like Proteins)
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (MIRN146 microRNA, human)
RN  - 0 (MIRN15 microRNA, human)
RN  - 0 (MIRN486 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - 0 (Peptide Hormones)
SB  - IM
MH  - Adolescent
MH  - Angiopoietin-Like Protein 8
MH  - Angiopoietin-like Proteins/*blood
MH  - Biomarkers/*blood
MH  - Blood Glucose/analysis
MH  - Case-Control Studies
MH  - Child
MH  - Diabetes Mellitus, Type 2/blood/genetics/*pathology
MH  - Female
MH  - Follow-Up Studies
MH  - Gene Expression Regulation
MH  - Humans
MH  - Insulin Resistance
MH  - Male
MH  - MicroRNAs/blood/*genetics
MH  - Obesity/blood/genetics/*pathology
MH  - Peptide Hormones/*blood
MH  - Prognosis
PMC - PMC7523287
OTO - NOTNLM
OT  - Betatrophin
OT  - Childhood obesity
OT  - T2DM
OT  - microRNA-146b and microRNA-15b
OT  - microRNA-486
COIS- The authors declare that they have no competing interests.
EDAT- 2020/09/30 06:00
MHDA- 2021/07/10 06:00
PMCR- 2020/09/29
CRDT- 2020/09/29 05:25
PHST- 2020/06/23 00:00 [received]
PHST- 2020/09/17 00:00 [accepted]
PHST- 2020/09/29 05:25 [entrez]
PHST- 2020/09/30 06:00 [pubmed]
PHST- 2021/07/10 06:00 [medline]
PHST- 2020/09/29 00:00 [pmc-release]
AID - 10.1186/s12902-020-00628-y [pii]
AID - 628 [pii]
AID - 10.1186/s12902-020-00628-y [doi]
PST - epublish
SO  - BMC Endocr Disord. 2020 Sep 29;20(1):145. doi: 10.1186/s12902-020-00628-y.