PMID- 32988645
OWN - NLM
STAT- MEDLINE
DCOM- 20210310
LR  - 20240403
IS  - 2173-5727 (Electronic)
IS  - 2173-5727 (Linking)
VI  - 45
IP  - 2
DP  - 2021 Mar
TI  - HLA genetic polymorphisms and prognosis of patients with COVID-19.
PG  - 96-103
LID - S0210-5691(20)30266-7 [pii]
LID - 10.1016/j.medin.2020.08.004 [doi]
AB  - OBJECTIVE: Different genetic polymorphisms of human leukocyte antigen (HLA) have 
      been associated with the risk and prognosis of autoimmune and infectious 
      diseases. The objectives of this study were to determine whether there is an 
      association between HLA genetic polymorphisms and the susceptibility to and 
      mortality of coronavirus disease 2019 (COVID-19) patients. DESIGN: Observational 
      and prospective study. SETTING: Eight Intensive Care Units (ICU) from 6 hospitals 
      of Canary Islands (Spain). PATIENTS: COVID-19 patients admitted in ICU and 
      healthy subjects. INTERVENTIONS: Determination of HLA genetic polymorphisms. MAIN 
      VARIABLE OF INTEREST: Mortality at 30 days. RESULTS: A total of 3886 healthy 
      controls and 72 COVID-19 patients (10 non-survivors and 62 survivor patients at 
      30 days) were included. We found a trend to a higher rate of the alleles HLA-A*32 
      (p=0.004) in healthy controls than in COVID-19 patients, and of the alleles 
      HLA-B*39 (p=0.02) and HLA-C*16 (p=0.02) in COVID-19 patients than in healthy 
      controls; however, all these p-values were not significant after correction for 
      multiple comparisons. Logistic regression analysis showed that the presence of 
      certain alleles was associated with higher mortality, such as the allele HLA-A*11 
      after controlling for SOFA (OR=7.693; 95% CI=1.063-55.650; p=0.04) or APACHE-II 
      (OR=11.858; 95% CI=1.524-92.273; p=0.02), the allele HLA-C*01 after controlling 
      for SOFA (OR=11.182; 95% CI=1.053-118.700; p=0.04) or APACHE-II (OR=17.604; 95% 
      CI=1.629-190.211; p=0.02), and the allele HLA-DQB1*04 after controlling for SOFA 
      (OR=9.963; 95% CI=1.235-80.358; p=0.03). CONCLUSIONS: The new finding from our 
      preliminary study of small sample size was that HLA genetic polymorphisms could 
      be associated with COVID-19 mortality; however, studies with a larger sample size 
      before definitive conclusions can be drawn.
CI  - Copyright (c) 2020 Elsevier Espana, S.L.U. y SEMICYUC. All rights reserved.
FAU - Lorente, L
AU  - Lorente L
AD  - Intensive Care Unit, Hospital Universitario de Canarias, Ofra, s/n., La Laguna 
      38320, Santa Cruz de Tenerife, Spain. Electronic address: lorentemartin@msn.com.
FAU - Martin, M M
AU  - Martin MM
AD  - Intensive Care Unit, Hospital Universitario Nuestra Senora de Candelaria, Crta 
      del Rosario s/n., Santa Cruz de Tenerife 38010, Spain.
FAU - Franco, A
AU  - Franco A
AD  - Immunology Unit of Laboratory Department, Hospital Universitario de Canarias, 
      Ofra, s/n., La Laguna 38320, Santa Cruz de Tenerife, Spain.
FAU - Barrios, Y
AU  - Barrios Y
AD  - Immunology Unit of Laboratory Department, Hospital Universitario de Canarias, 
      Ofra, s/n., La Laguna 38320, Santa Cruz de Tenerife, Spain.
FAU - Caceres, J J
AU  - Caceres JJ
AD  - Intensive Care Unit, Hospital Insular, Plaza Dr. Pasteur s/n., Las Palmas de Gran 
      Canaria 35016, Spain.
FAU - Sole-Violan, J
AU  - Sole-Violan J
AD  - Intensive Care Unit, Hospital Universitario Dr. Negrin, Barranco de la Ballena 
      s/n., Las Palmas de Gran Canaria 35010, Spain.
FAU - Perez, A
AU  - Perez A
AD  - Internal Intensive Care Unit, Hospital Universitario de Canarias, Ofra, s/n., La 
      Laguna 38320, Santa Cruz de Tenerife, Spain.
FAU - Marcos Y Ramos, J A
AU  - Marcos Y Ramos JA
AD  - Intensive Care Unit, Hospital Doctor Jose Molina Orosa, Ctra. Arrecife-Tinajo, km 
      1.300, Arrecife, Lanzarote 35550, Spain.
FAU - Ramos-Gomez, L
AU  - Ramos-Gomez L
AD  - Intensive Care Unit, Hospital General La Palma, Buenavista de Arriba s/n, Brena 
      Alta, La Palma 38713, Spain.
FAU - Ojeda, N
AU  - Ojeda N
AD  - Department of Anesthesiology, Hospital Universitario Dr. Negrin, Barranco de la 
      Ballena s/n., Las Palmas de Gran Canaria 35010, Spain.
FAU - Jimenez, A
AU  - Jimenez A
AD  - Research Unit, Hospital Universitario de Canarias, Ofra, s/n., La Laguna 38320, 
      Santa Cruz de Tenerife, Spain.
CN  - Working Group on COVID-19 Canary ICU
CN  - Annex. Members of the BIOMEPOC group
LA  - eng
LA  - spa
PT  - Journal Article
PT  - Multicenter Study
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
TT  - Polimorfismos geneticos de los HLA y pronostico de pacientes con COVID-19.
DEP - 20200906
PL  - Spain
TA  - Med Intensiva (Engl Ed)
JT  - Medicina intensiva
JID - 101717568
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A3 Antigen)
RN  - 0 (HLA-B39 Antigen)
RN  - 0 (HLA-C Antigens)
SB  - IM
CIN - Med Intensiva (Engl Ed). 2022 Mar;46(3):172-173. PMID: 34996743
CIN - Med Intensiva (Engl Ed). 2022 Mar;46(3):171-172. PMID: 34998724
MH  - APACHE
MH  - Aged
MH  - Alleles
MH  - COVID-19/*genetics/mortality
MH  - Case-Control Studies
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA Antigens/*genetics
MH  - HLA-A3 Antigen
MH  - HLA-B39 Antigen/genetics
MH  - HLA-C Antigens/genetics
MH  - Humans
MH  - Intensive Care Units
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Organ Dysfunction Scores
MH  - *Polymorphism, Genetic
MH  - Preliminary Data
MH  - Prognosis
MH  - Prospective Studies
MH  - Regression Analysis
MH  - Spain/epidemiology
PMC - PMC7905376
OTO - NOTNLM
OT  - COVID-19
OT  - Genetic polymorphisms
OT  - HLA
OT  - Mortalidad
OT  - Mortality
OT  - Outcome
OT  - Polimorfismos geneticos
OT  - Pronostico
FIR - Lorente, Leonardo
IR  - Lorente L
IRAD- Hospital Universitario de Canarias, La Laguna, Tenerife, Spain.
FIR - Franco, Andres
IR  - Franco A
IRAD- Hospital Universitario de Canarias, La Laguna, Tenerife, Spain.
FIR - Barrios, Yvelise
IR  - Barrios Y
IRAD- Hospital Universitario de Canarias, La Laguna, Tenerife, Spain.
FIR - Perez, Alina
IR  - Perez A
IRAD- Hospital Universitario de Canarias, La Laguna, Tenerife, Spain.
FIR - Jimenez, Alejandro
IR  - Jimenez A
IRAD- Hospital Universitario de Canarias, La Laguna, Tenerife, Spain.
FIR - Perez-Cejas, Antonia
IR  - Perez-Cejas A
IRAD- Hospital Universitario de Canarias, La Laguna, Tenerife, Spain.
FIR - Perez-Llombet, Alejandra
IR  - Perez-Llombet A
IRAD- Hospital Universitario de Canarias, La Laguna, Tenerife, Spain.
FIR - Uribe, Luis
IR  - Uribe L
IRAD- Hospital Universitario de Canarias, La Laguna, Tenerife, Spain.
FIR - Gonzalez, Lourdes
IR  - Gonzalez L
IRAD- Hospital Universitario de Canarias, La Laguna, Tenerife, Spain.
FIR - Alvarez, Rocio
IR  - Alvarez R
IRAD- Hospital Universitario de Canarias, La Laguna, Tenerife, Spain.
FIR - Martin, Maria M
IR  - Martin MM
IRAD- Hospital Universitario Nuestra Senora de Candelaria, Santa Cruz de Tenerife, 
      Spain.
FIR - Alcoba-Florez, Julia
IR  - Alcoba-Florez J
IRAD- Hospital Universitario Nuestra Senora de Candelaria, Santa Cruz de Tenerife, 
      Spain.
FIR - Estupinan, Albano
IR  - Estupinan A
IRAD- Hospital Universitario Nuestra Senora de Candelaria, Santa Cruz de Tenerife, 
      Spain.
FIR - Caceres, Juan J
IR  - Caceres JJ
IRAD- Hospital Insular, Las Palmas de Gran Canaria, Spain.
FIR - Vega, Paula
IR  - Vega P
IRAD- Hospital Insular, Las Palmas de Gran Canaria, Spain.
FIR - Gonzalez, Lucia
IR  - Gonzalez L
IRAD- Hospital Insular, Las Palmas de Gran Canaria, Spain.
FIR - Sole-Violan, Jordi
IR  - Sole-Violan J
IRAD- Hospital Universitario Dr, Negrin, Las Palmas de Gran Canaria, Spain.
FIR - Ojeda, Nazario
IR  - Ojeda N
IRAD- Hospital Universitario Dr, Negrin, Las Palmas de Gran Canaria, Spain.
FIR - Lopez, Sergio
IR  - Lopez S
IRAD- Hospital Universitario Dr, Negrin, Las Palmas de Gran Canaria, Spain.
FIR - Rodriguez-Perez, Aurelio
IR  - Rodriguez-Perez A
IRAD- Hospital Universitario Dr, Negrin, Las Palmas de Gran Canaria, Spain.
FIR - Dominguez, Casimira
IR  - Dominguez C
IRAD- Hospital Universitario Dr, Negrin, Las Palmas de Gran Canaria, Spain.
FIR - Marcos Y Ramos, Jose Alberto
IR  - Marcos Y Ramos JA
IRAD- Hospital Doctor Jose Molina Orosa, Lanzarote, Spain.
FIR - Zapata, Maria F
IR  - Zapata MF
IRAD- Hospital Doctor Jose Molina Orosa, Lanzarote, Spain.
FIR - Ramos-Gomez, Luis
IR  - Ramos-Gomez L
IRAD- Hospital General La Palma, La Palma, Spain.
FIR - Ortiz-Lopez, Raquel
IR  - Ortiz-Lopez R
IRAD- Hospital General La Palma, La Palma, Spain.
EDAT- 2020/09/30 06:00
MHDA- 2021/03/11 06:00
PMCR- 2021/02/25
CRDT- 2020/09/29 05:29
PHST- 2020/06/09 00:00 [received]
PHST- 2020/07/22 00:00 [revised]
PHST- 2020/08/07 00:00 [accepted]
PHST- 2020/09/30 06:00 [pubmed]
PHST- 2021/03/11 06:00 [medline]
PHST- 2020/09/29 05:29 [entrez]
PHST- 2021/02/25 00:00 [pmc-release]
AID - S0210-5691(20)30266-7 [pii]
AID - 10.1016/j.medin.2020.08.004 [doi]
PST - ppublish
SO  - Med Intensiva (Engl Ed). 2021 Mar;45(2):96-103. doi: 10.1016/j.medin.2020.08.004. 
      Epub 2020 Sep 6.