PMID- 32988848 OWN - NLM STAT- MEDLINE DCOM- 20210621 LR - 20240802 IS - 2052-4897 (Electronic) IS - 2052-4897 (Linking) VI - 8 IP - 1 DP - 2020 Sep TI - Role of resistin, IL-6 and NH2-terminal portion proBNP in the pathogenesis of cardiac disease in type 2 diabetes mellitus. LID - 10.1136/bmjdrc-2020-001206 [doi] LID - e001206 AB - INTRODUCTION: Epidemiological and genetic studies have recorded the association between proinflammatory cytokines and the development of insulin resistance, diabetes, and cardiovascular disease. The role of interleukin 6 (IL-6), NH2-terminal portion pro-brain natriuretic peptide (NT-proBNP) and resistin in the pathogenesis of heart disease in type 2 diabetes mellitus (T2DM) is still a matter of controversy. The current study aimed to evaluate the role of these biomarkers in the development of left ventricular systolic dysfunction and the ability to use them as non-invasive test in the prediction of left ventricular hypertrophy and systolic dysfunction in T2DM. RESEARCH DESIGN AND METHODS: 150 participants were included in this case-control study. Patients were divided into two subgroups according to echocardiographic findings: group 1a included 46 patients with type 2 diabetes mellitus and echocardiographic evidence of abnormal systolic function; group 1b included 54 patients with type 2 diabetes mellitus and with normal echocardiogenic study; and group 2 included 50 apparently healthy controls. Routine laboratory investigations such as complete blood count, liver and renal function tests, and lipid profile, serum IL-6, NT-proBNP, and resistin were measured in all participants. Conventional echocardiography was done with special concern on the assessment of left ventricular systolic function (ejection fraction). RESULTS: There was a significant increase in the level of resistin, NT-proBNP and IL-6 in group 1a patients compared with group 1b and in healthy controls. Echocardiographic parameters showed a significant increase in left ventricular mass index, left ventricle posterior wall thickness, interventricular septum thickness, and left ventricle mass in group 1a compared with group 1b and the control group. The increased left ventricular mass index was associated with higher levels of IL-6, NT-proBNP and resistin. CONCLUSIONS: Proinflammatory cytokines had a clear relation with left ventricular systolic dysfunction and hypertrophy and can be used as early non-invasive markers for detection of left ventricular remodeling and systolic dysfunction in patients with T2DM. CI - (c) Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. FAU - Ghanem, Samar Ebrahim AU - Ghanem SE AD - Department of Clinical Biochemistry and Molecular Diagnostics, National Liver Institute, Menoufia University, Menoufia, Egypt. FAU - Abdel-Samiee, Mohamed AU - Abdel-Samiee M AUID- ORCID: 0000-0002-8970-0286 AD - Department of Hepatology and Gastroenterology, National Liver Institute, Menoufia University, Menoufia, Egypt drmohammed100@yahoo.com. FAU - Torky, Mohamed Hamdy AU - Torky MH AD - Department of Cardiology, Shibin Elkom Teaching Hospital, Menoufia, Egypt. FAU - Gaafar, Ahmed AU - Gaafar A AD - Department of Cardiology, Helwan University, Cairo, Egypt. FAU - Mohamed, Somia Mokabel AU - Mohamed SM AD - Department of Physiology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt. FAU - Salah Eldin, Ghada Mohamed Mohamed AU - Salah Eldin GMM AD - Department of Physiology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt. FAU - Awad, Samah Mohammed AU - Awad SM AD - Department of Clinical Microbiology and Immunology and Molecular Microbiology in Liver and GIT, National Liver Institute, Menoufia University, Menoufia, Egypt. FAU - Diab, Karema A AU - Diab KA AD - Department of Clinical Pathology, National Liver Institute, Menoufia University, Menoufia, Egypt. FAU - ELsabaawy, Dalia M AU - ELsabaawy DM AD - Department of Clinical Pharmacy, Faculty of Pharmacy, Menoufia University, Menoufia, Egypt. FAU - Yehia, Sania Ali AU - Yehia SA AD - Department of Epidemiology and Preventive Medicine, National Liver Institute, Menoufia University, Menoufia, Egypt. FAU - Abdelaziz Elbasyouni, Hany Abdelbary AU - Abdelaziz Elbasyouni HA AD - Department of Internal Medicine, Faculty of Medicine, Menoufia University, Menoufia, Egypt. FAU - Elshormilisy, Amr Aly AU - Elshormilisy AA AD - Department of Internal Medicine, Helwan University, Cairo, Egypt. LA - eng PT - Journal Article PL - England TA - BMJ Open Diabetes Res Care JT - BMJ open diabetes research & care JID - 101641391 RN - 0 (Interleukin-6) RN - 0 (Resistin) RN - 114471-18-0 (Natriuretic Peptide, Brain) SB - IM MH - Case-Control Studies MH - *Diabetes Mellitus, Type 2/complications MH - Humans MH - Interleukin-6 MH - Natriuretic Peptide, Brain MH - Resistin MH - *Ventricular Dysfunction, Left/etiology PMC - PMC7523202 OTO - NOTNLM OT - adult diabetes OT - echocardiography OT - interleukin-6 COIS- Competing interests: None declared. EDAT- 2020/09/30 06:00 MHDA- 2021/06/22 06:00 PMCR- 2020/09/28 CRDT- 2020/09/29 05:30 PHST- 2020/01/17 00:00 [received] PHST- 2020/05/29 00:00 [revised] PHST- 2020/08/04 00:00 [accepted] PHST- 2020/09/29 05:30 [entrez] PHST- 2020/09/30 06:00 [pubmed] PHST- 2021/06/22 06:00 [medline] PHST- 2020/09/28 00:00 [pmc-release] AID - 8/1/e001206 [pii] AID - bmjdrc-2020-001206 [pii] AID - 10.1136/bmjdrc-2020-001206 [doi] PST - ppublish SO - BMJ Open Diabetes Res Care. 2020 Sep;8(1):e001206. doi: 10.1136/bmjdrc-2020-001206.