PMID- 32988889
OWN - NLM
STAT- MEDLINE
DCOM- 20201007
LR  - 20201007
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 40
IP  - 10
DP  - 2020 Oct
TI  - The Relationship of GATA3 and Ki-67 With Histopathological Prognostic Parameters, 
      Locoregional Recurrence and Disease-free Survival in Invasive Ductal Carcinoma of 
      the Breast.
PG  - 5649-5657
LID - 10.21873/anticanres.14578 [doi]
AB  - BACKGROUND: In recent years, GATA-binding protein 3 (GATA3) has been indicated as 
      a marker showing good prognosis in breast cancer. In luminal breast cancer, which 
      has good a prognosis, it shows more significant elevation in small-sized and 
      low-grade tumors. In contrast, Ki-67 is defined as a poor prognostic factor. The 
      aim of this study was to emphasise the prognostic importance of GATA3 and the 
      inverse relationship with Ki-67. MATERIALS AND METHODS: In our study, 90 patients 
      with invasive ductal breast cancer were immunohistochemically evaluated for Ki-67 
      and GATA3 expression. The relationship between GATA3 and Ki-67 expression was 
      examined. In addition, the relationship between these two factors with estrogen, 
      progesterone, human epidermal growth factor 2 receptor antibodies and other 
      prognostic parameters such as disease-free survival and local recurrence was 
      investigated. We accepted the level of >/=5% nuclear reaction as positive for GATA 
      3. A Ki-67 cut-off value of 20% was accepted as positive. RESULTS: In GATA3 
      positive breast cancers, good prognostic parameters were seen including high 
      estrogen receptor (ER) positivity, progesterone receptor (PR) positivity, small 
      tumor size and low histological grade as well as low Ki-67 expression. In breast 
      cancers showing high Ki-67 expression, ER, PR, and GATA3 positivity were lower 
      and there was higher human epidermal growth factor receptor 2 (HER2) positivity 
      and high histological grade while the tumor size was larger. CONCLUSION: Our 
      study has revealed that GATA3 has an inverse relationship with Ki-67, whereas it 
      has a positive releationship with good prognostic factors.
CI  - Copyright(c) 2020, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Yildirim, Emine
AU  - Yildirim E
AD  - Department of General Surgery, University of Health Sciences Turkey, 
      Gaziosmanpasa Training and Research Hospital, Istanbul, Turkey 
      opdreyildirim@gmail.com.
FAU - Bektas, Sibel
AU  - Bektas S
AD  - Department of Pathology, University of Health Sciences Turkey, Gaziosmanpasa 
      Training and Research Hospital, Istanbul, Turkey.
FAU - Gundogar, Ozgecan
AU  - Gundogar O
AD  - Department of Pathology, Bahcelievler Government Hospital, Istanbul, Turkey.
FAU - Findik, Deniz
AU  - Findik D
AD  - Department of General Surgery, University of Health Sciences Turkey, 
      Gaziosmanpasa Training and Research Hospital, Istanbul, Turkey.
FAU - Alcicek, Serap
AU  - Alcicek S
AD  - Department of General Surgery, University of Health Sciences Turkey, 
      Gaziosmanpasa Training and Research Hospital, Istanbul, Turkey.
FAU - Erdogan, Kivilcim Orhun
AU  - Erdogan KO
AD  - Department of General Surgery, University of Health Sciences Turkey, 
      Gaziosmanpasa Training and Research Hospital, Istanbul, Turkey.
FAU - Yildiz, Mete
AU  - Yildiz M
AD  - Department of General Surgery, Duzici Government Hospital, Osmaniye, Turkey.
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Estrogens)
RN  - 0 (GATA3 Transcription Factor)
RN  - 0 (GATA3 protein, human)
RN  - 0 (Ki-67 Antigen)
RN  - 0 (Receptors, Estrogen)
RN  - 0 (Receptors, Progesterone)
RN  - 4G7DS2Q64Y (Progesterone)
RN  - EC 2.7.10.1 (ERBB2 protein, human)
RN  - EC 2.7.10.1 (Receptor, ErbB-2)
SB  - IM
MH  - Adult
MH  - Biomarkers, Tumor
MH  - Carcinoma, Ductal, Breast/epidemiology/*genetics/pathology
MH  - Disease-Free Survival
MH  - Estrogens/genetics
MH  - Female
MH  - GATA3 Transcription Factor/*genetics
MH  - Gene Expression Regulation, Neoplastic/genetics
MH  - Humans
MH  - Ki-67 Antigen/*genetics
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local/epidemiology/*genetics/pathology
MH  - Progesterone/genetics
MH  - Prognosis
MH  - Receptor, ErbB-2/genetics
MH  - Receptors, Estrogen/genetics
MH  - Receptors, Progesterone/genetics
OTO - NOTNLM
OT  - Breast cancer
OT  - GATA3
OT  - Ki-67
OT  - prognostic parameters
EDAT- 2020/09/30 06:00
MHDA- 2020/10/08 06:00
CRDT- 2020/09/29 05:31
PHST- 2020/05/04 00:00 [received]
PHST- 2020/07/15 00:00 [revised]
PHST- 2020/07/17 00:00 [accepted]
PHST- 2020/09/29 05:31 [entrez]
PHST- 2020/09/30 06:00 [pubmed]
PHST- 2020/10/08 06:00 [medline]
AID - 40/10/5649 [pii]
AID - 10.21873/anticanres.14578 [doi]
PST - ppublish
SO  - Anticancer Res. 2020 Oct;40(10):5649-5657. doi: 10.21873/anticanres.14578.