PMID- 32990580
OWN - NLM
STAT- MEDLINE
DCOM- 20201008
LR  - 20201218
IS  - 1522-6662 (Electronic)
IS  - 1098-3511 (Linking)
VI  - 23
IP  - 5
DP  - 2020 Aug 5
TI  - The Effect of Atrial Septal Defect in the Treatment of ARDS with Left Ventricular 
      Dysfunction Simulating Severe COVID-19.
PG  - E574-E578
LID - 10.1532/hsf.3077 [doi]
AB  - OBJECTIVE: To explore the effect of atrial septal defect (ASD) and venoarterial 
      extracorporeal membrane oxygenation (VA-ECMO) in the treatment of ARDS combined 
      with left ventricular dysfunction (LVD) to find a new effective method for 
      treating severe COVID-19 patients. MATERIALS AND METHODS: Five large animal ARDS 
      models of sheep were established by intravenous injection of Lipopolysaccharide. 
      ASD was made under general anesthesia and VA-ECMO was simulated by extracorporeal 
      circulation machine. The oxygenation of peripheral blood, systemic circulation, 
      and cardiac function were observed under conditions of closed and opened ASD, and 
      the significance of ASD shunt in improving cardiopulmonary function was 
      evaluated. RESULTS: With ASD closed, the atrial shunts disappeared, the 
      peripheral artery pressure of oxygen(PaO2): 141.2+/-21.4mmHg, the oxygenation index 
      (PaO2/FiO2): 353.0+/-53.5, the mean blood pressure (MAP): 49.3+/-13.5 mmHg, the heart 
      was full; with ASD opened, the left-to-right shunt was observed, PaO2: 
      169.3+/-18.9mmHg, PaO2/FiO2: 423.3+/-47.3, MAP: 68.2+/-16.1 mmHg, the range of cardiac 
      motion significantly increased, heart beat was powerful, and systemic circulation 
      significantly improved. Statistical analysis showed that there were significant 
      differences between opened and closed ASD (P < .01). CONCLUSION: ASD plus VA-ECMO 
      is an effective method for the treatment of ARDS combined with LVD, which is the 
      main cause of death in severe COVID-19 patients. However, further clinical 
      validation is needed.
FAU - Diao, Liwei
AU  - Diao L
AD  - Shenzhen Hospital, University of Chinese Academy of Sciences, Guangdong, China. 
      doctor_dlw@126.com.
FAU - Yang, Yingjie
AU  - Yang Y
AD  - Third Hospital, Xinxiang Medical University, Henan, China. 
      Liwenbin65@Vip.Sina.com.
FAU - Zhang, Baoquan
AU  - Zhang B
AD  - Third Hospital, Xinxiang Medical University, Henan, China. 
      Liwenbin65@Vip.Sina.com.
FAU - Shi, Qizhong
AU  - Shi Q
AD  - Third Hospital, Xinxiang Medical University, Henan, China. 
      Liwenbin65@Vip.Sina.com.
FAU - Fan, Hongzhe
AU  - Fan H
AD  - Third Hospital, Xinxiang Medical University, Henan, China. 
      Liwenbin65@Vip.Sina.com.
FAU - Liu, Jie
AU  - Liu J
AD  - Third Hospital, Xinxiang Medical University, Henan, China. 
      Liwenbin65@Vip.Sina.co.
FAU - Li, Yangyang
AU  - Li Y
AD  - Third Hospital, Xinxiang Medical University, Henan, China. 
      Liwenbin65@Vip.Sina.com.
FAU - Wu, Benqing
AU  - Wu B
AD  - Shenzhen Hospital, University of Chinese Academy of Sciences, Guangdong, China. 
      Liwenbin65@Vip.Sina.com.
FAU - Wu, Yibin
AU  - Wu Y
AD  - Shenzhen Hospital, University of Chinese Academy of Sciences, Guangdong, China. 
      Liwenbin65@Vip.Sina.com.
FAU - Qiu, Haiyi
AU  - Qiu H
AD  - Shenzhen Hospital, University of Chinese Academy of Sciences, Guangdong, China. 
      Liwenbin65@Vip.Sina.com.
FAU - Li, Wenbin
AU  - Li W
AD  - Shenzhen Hospital, University of Chinese Academy of Sciences, Guangdong, China. 
      Liwenbin65@Vip.Sina.com.
LA  - eng
PT  - Journal Article
DEP - 20200805
PL  - United States
TA  - Heart Surg Forum
JT  - The heart surgery forum
JID - 100891112
SB  - IM
MH  - Animals
MH  - *Betacoronavirus
MH  - COVID-19
MH  - Coronavirus Infections/*complications
MH  - Diagnosis, Differential
MH  - Disease Models, Animal
MH  - *Extracorporeal Membrane Oxygenation
MH  - Heart Septal Defects, Atrial/*complications
MH  - Pandemics
MH  - Pneumonia, Viral/*complications
MH  - Respiratory Distress Syndrome/etiology/*therapy
MH  - SARS-CoV-2
MH  - Sheep
MH  - Ventricular Dysfunction, Left/*complications
EDAT- 2020/09/30 06:00
MHDA- 2020/10/09 06:00
CRDT- 2020/09/29 12:34
PHST- 2020/05/19 00:00 [received]
PHST- 2020/06/02 00:00 [accepted]
PHST- 2020/09/29 12:34 [entrez]
PHST- 2020/09/30 06:00 [pubmed]
PHST- 2020/10/09 06:00 [medline]
AID - 10.1532/hsf.3077 [doi]
PST - epublish
SO  - Heart Surg Forum. 2020 Aug 5;23(5):E574-E578. doi: 10.1532/hsf.3077.